Reactome | Toll-like Receptor Cascades

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Toll-like Receptor Cascades Show undefined attributes

authored	[InstanceEdit:188947] de Bono, B, Gillespie, ME, Luo, F, Gay, NJ, 0000-00-00 00:00:00
created	[InstanceEdit:168899] de Bono, B, 2005-11-22 18:20:21
dbId	168898
displayName	Toll-like Receptor Cascades
eventOf	[Pathway:R-HSA-168249] Innate Immune System - Homo sapiens
figure	[Figure:9918397] /figures/static/R-HSA-168898.svg
goBiologicalProcess	[GO_BiologicalProcess:258822] toll-like receptor signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-1679131] Trafficking and processing of endosomal TLR - Homo sapiens [Pathway:R-HSA-168142] Toll Like Receptor 10 (TLR10) Cascade - Homo sapiens [Pathway:R-HSA-168164] Toll Like Receptor 3 (TLR3) Cascade - Homo sapiens [Pathway:R-HSA-168176] Toll Like Receptor 5 (TLR5) Cascade - Homo sapiens [Pathway:R-HSA-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - Homo sapiens [Pathway:R-HSA-168138] Toll Like Receptor 9 (TLR9) Cascade - Homo sapiens [Pathway:R-HSA-166016] Toll Like Receptor 4 (TLR4) Cascade - Homo sapiens [Pathway:R-HSA-181438] Toll Like Receptor 2 (TLR2) Cascade - Homo sapiens [Pathway:R-HSA-5686938] Regulation of TLR by endogenous ligand - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-09-13
literatureReference	[LiteratureReference:168201] TIR domains, which are conserved among all TLRs. Recent accumulating [LiteratureReference:169782] Toll-like receptor signaling [LiteratureReference:168196] TIRAP/Mal, TRIF and TRAM. Differential utilization of these TIR [LiteratureReference:169814] Pathogen recognition with Toll-like receptors [LiteratureReference:169812] Recognition of bacterial products by toll-like receptors
maxDepth	9
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Toll-like Receptor Cascades
orthologousEvent	[Pathway:R-MMU-168898] Toll-like Receptor Cascades - Mus musculus [Pathway:R-RNO-168898] Toll-like Receptor Cascades - Rattus norvegicus [Pathway:R-CFA-168898] Toll-like Receptor Cascades - Canis familiaris [Pathway:R-BTA-168898] Toll-like Receptor Cascades - Bos taurus [Pathway:R-SSC-168898] Toll-like Receptor Cascades - Sus scrofa [Pathway:R-DRE-168898] Toll-like Receptor Cascades - Danio rerio [Pathway:R-XTR-168898] Toll-like Receptor Cascades - Xenopus tropicalis [Pathway:R-GGA-168898] Toll-like Receptor Cascades - Gallus gallus [Pathway:R-CEL-168898] Toll-like Receptor Cascades - Caenorhabditis elegans [Pathway:R-SPO-168898] Toll-like Receptor Cascades - Schizosaccharomyces pombe [Pathway:R-SCE-168898] Toll-like Receptor Cascades - Saccharomyces cerevisiae [Pathway:R-DME-168898] Toll-like Receptor Cascades - Drosophila melanogaster [Pathway:R-DDI-168898] Toll-like Receptor Cascades - Dictyostelium discoideum [Pathway:R-PFA-168898] Toll-like Receptor Cascades - Plasmodium falciparum
relatedSpecies	[Species:181384] Chlamydia trachomatis [Species:159879] Escherichia coli [Species:180800] Neisseria meningitidis serogroup B [Species:188092] Toxoplasma gondii [Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188964] D'Eustachio, P, Gale M, Jr, Gay, NJ, 2006-10-31 16:43:59
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-168898
summation	[Summation:169785] In human, ten members of the Toll-like receptor (TLR) family...
updateTrackers	[UpdateTracker:9783253] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v57:[addHasEvent] [UpdateTracker:9787479] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v45:[modifyText, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9789216] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v38:[addLiteratureReference, modifyText, updateContainedPathway] [UpdateTracker:9788595] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v41:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9777964] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v68:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9776916] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v74:[modifyText, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9911044] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v89:[updateContainedPathway] [UpdateTracker:9790512] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v33:[updateContainedPathway] [UpdateTracker:9790210] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v34:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9788504] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v42:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9789744] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v37:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9776409] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v76:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9783949] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v55:[updateIndirectRLE] [UpdateTracker:9780616] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v62:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9846783] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v84:[updateContainedPathway] [UpdateTracker:9780330] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v63:[updateContainedPathway] [UpdateTracker:9784879] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v52:[updateIndirectRLE] [UpdateTracker:9775247] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v80:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9790060] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v35:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9842234] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v86:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9782830] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v58:[updateIndirectRLE] [UpdateTracker:9780056] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v64:[updateIndirectRLE] [UpdateTracker:9786690] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v49:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9777011] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v73:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9775280] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v79:[updateIndirectRLE] [UpdateTracker:9784341] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v54:[updateIndirectRLE] [UpdateTracker:9789974] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v36:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9864248] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v88:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9791190] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v32:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9782216] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v59:[updateIndirectRLE] [UpdateTracker:9774632] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v81:[updateContainedPathway] [UpdateTracker:9778848] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v67:[updateContainedPathway] [UpdateTracker:9788724] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v40:[addHasEvent, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9789023] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v39:[updateIndirectRLE] [UpdateTracker:9788274] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v43:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9791753] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v26:[removeHasEvent]

Referrals

(hasEvent)	[Pathway:R-HSA-168249] Innate Immune System
(hasEncapsulatedEvent)	[Pathway:R-HSA-9833110] RSV-host interactions
(updatedInstance)	[UpdateTracker:9783253] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v57:[addHasEvent] [UpdateTracker:9787479] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v45:[modifyText, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9789216] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v38:[addLiteratureReference, modifyText, updateContainedPathway] [UpdateTracker:9788595] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v41:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9777964] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v68:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9776916] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v74:[modifyText, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9911044] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v89:[updateContainedPathway] [UpdateTracker:9790512] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v33:[updateContainedPathway] [UpdateTracker:9790210] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v34:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9788504] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v42:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9789744] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v37:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9776409] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v76:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9783949] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v55:[updateIndirectRLE] [UpdateTracker:9780616] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v62:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9846783] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v84:[updateContainedPathway] [UpdateTracker:9780330] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v63:[updateContainedPathway] [UpdateTracker:9784879] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v52:[updateIndirectRLE] [UpdateTracker:9775247] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v80:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9790060] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v35:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9842234] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v86:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9782830] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v58:[updateIndirectRLE] [UpdateTracker:9780056] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v64:[updateIndirectRLE] [UpdateTracker:9786690] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v49:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9777011] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v73:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9775280] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v79:[updateIndirectRLE] [UpdateTracker:9784341] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v54:[updateIndirectRLE] [UpdateTracker:9789974] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v36:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9864248] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v88:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9791190] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v32:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9782216] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v59:[updateIndirectRLE] [UpdateTracker:9774632] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v81:[updateContainedPathway] [UpdateTracker:9778848] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v67:[updateContainedPathway] [UpdateTracker:9788724] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v40:[addHasEvent, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9789023] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v39:[updateIndirectRLE] [UpdateTracker:9788274] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v43:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9791753] Update Tracker - [Pathway:168898] Toll-like Receptor Cascades - v26:[removeHasEvent]

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