Reactome | DDX58/IFIH1-mediated induction of interferon-alpha/beta

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DDX58/IFIH1-mediated induction of interferon-alpha/beta Show undefined attributes

authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:168919] de Bono, B, 2005-11-22 18:36:47
dbId	168928
displayName	DDX58/IFIH1-mediated induction of interferon-alpha/beta
doi	10.3180/R-HSA-168928.9
edited	[InstanceEdit:918228] Garapati, P V, 2010-08-02
eventOf	[Pathway:R-HSA-168249] Innate Immune System - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-168935] viral dsRNA binds DDX58 - Homo sapiens [Reaction:R-HSA-918224] DDX58 is K63 polyubiquitinated - Homo sapiens [Reaction:R-HSA-913725] viral dsRNA binds IFIH1:TKFC - Homo sapiens [Reaction:R-HSA-168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS - Homo sapiens [Pathway:R-HSA-918233] TRAF3-dependent IRF activation pathway - Homo sapiens [Pathway:R-HSA-933543] NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 - Homo sapiens [Pathway:R-HSA-933541] TRAF6 mediated IRF7 activation - Homo sapiens [Pathway:R-HSA-933542] TRAF6 mediated NF-kB activation - Homo sapiens [Pathway:R-HSA-936440] Negative regulators of DDX58/IFIH1 signaling - Homo sapiens [Reaction:R-HSA-9709831] HSP90 binds TBK1 and IRF3 - Homo sapiens [Reaction:R-HSA-9709842] MAVS binds TOMM70 - Homo sapiens [Reaction:R-HSA-9709852] MAVS:TOMM70 recruits HSP90:TBK1:IRF3 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-09-13
literatureReference	[LiteratureReference:168931] Regulation of the type I IFN induction: a current view [LiteratureReference:933493] Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity [LiteratureReference:936501] Viral evasion and subversion of pattern-recognition receptor signalling [LiteratureReference:936499] Structural mechanism of RNA recognition by the RIG-I-like receptors [LiteratureReference:936500] RIG-I family RNA helicases: cytoplasmic sensor for antiviral innate immunity [LiteratureReference:936494] Function of RIG-I-like receptors in antiviral innate immunity
maxDepth	3
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	DDX58/IFIH1-mediated induction of interferon-alpha/beta RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
orthologousEvent	[Pathway:R-MMU-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - Mus musculus [Pathway:R-RNO-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - Rattus norvegicus [Pathway:R-CFA-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - Canis familiaris [Pathway:R-BTA-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - Bos taurus [Pathway:R-SSC-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - Sus scrofa [Pathway:R-DRE-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - Danio rerio [Pathway:R-XTR-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - Xenopus tropicalis [Pathway:R-GGA-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - Gallus gallus [Pathway:R-DME-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - Drosophila melanogaster [Pathway:R-CEL-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - Caenorhabditis elegans [Pathway:R-DDI-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - Dictyostelium discoideum
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:9013948] Measles virus [Species:5617433] Rotavirus [Species:9031716] Influenza A virus [Species:9717528] Human respiratory syncytial virus A
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-168928
summation	[Summation:177862] RIG-I-like helicases (RLHs) the retinoic acid inducible gene...
updateTrackers	[UpdateTracker:9777998] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v68:[updateIndirectRLE] [UpdateTracker:9789939] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v36:[updateIndirectRLE] [UpdateTracker:9783258] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v57:[updateIndirectRLE] [UpdateTracker:9788144] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v43:[updateIndirectRLE] [UpdateTracker:9789666] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v37:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9780565] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v62:[updateContainedRLE] [UpdateTracker:9928486] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v91:[modifyText] [UpdateTracker:9788728] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v40:[updateIndirectRLE] [UpdateTracker:9780048] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v64:[updateContainedRLE] [UpdateTracker:9776380] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v76:[addHasEvent, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9775609] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v78:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9774660] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v81:[updateIndirectRLE] [UpdateTracker:9788929] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v39:[updateIndirectRLE] [UpdateTracker:9782562] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v59:[updateIndirectRLE] [UpdateTracker:9775115] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v80:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9842285] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v86:[updateIndirectRLE] [UpdateTracker:9780923] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v61:[updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9776191] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v77:[modifyText, updateContainedRLE] [UpdateTracker:9787723] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v44:[updateIndirectRLE] [UpdateTracker:9835768] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v85:[updateIndirectRLE] [UpdateTracker:9786887] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v47:[updateContainedPathway] [UpdateTracker:9779532] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v65:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9784049] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v54:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9781652] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v60:[updateIndirectRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-168249] Innate Immune System
(hasEncapsulatedEvent)	[Pathway:R-HSA-9920588] Dengue virus activates/modulates innate and adaptive immune responses [Pathway:R-HSA-1834949] Cytosolic sensors of pathogen-associated DNA [Pathway:R-HSA-9833110] RSV-host interactions [Pathway:R-HSA-9705683] SARS-CoV-2-host interactions [Pathway:R-HSA-9692914] SARS-CoV-1-host interactions
(updatedInstance)	[UpdateTracker:9777998] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v68:[updateIndirectRLE] [UpdateTracker:9789939] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v36:[updateIndirectRLE] [UpdateTracker:9783258] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v57:[updateIndirectRLE] [UpdateTracker:9788144] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v43:[updateIndirectRLE] [UpdateTracker:9789666] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v37:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9780565] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v62:[updateContainedRLE] [UpdateTracker:9928486] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v91:[modifyText] [UpdateTracker:9788728] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v40:[updateIndirectRLE] [UpdateTracker:9780048] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v64:[updateContainedRLE] [UpdateTracker:9776380] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v76:[addHasEvent, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9775609] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v78:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9774660] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v81:[updateIndirectRLE] [UpdateTracker:9788929] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v39:[updateIndirectRLE] [UpdateTracker:9782562] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v59:[updateIndirectRLE] [UpdateTracker:9775115] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v80:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9842285] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v86:[updateIndirectRLE] [UpdateTracker:9780923] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v61:[updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9776191] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v77:[modifyText, updateContainedRLE] [UpdateTracker:9787723] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v44:[updateIndirectRLE] [UpdateTracker:9835768] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v85:[updateIndirectRLE] [UpdateTracker:9786887] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v47:[updateContainedPathway] [UpdateTracker:9779532] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v65:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9784049] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v54:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9781652] Update Tracker - [Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - v60:[updateIndirectRLE]

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