Reactome | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10

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NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Show undefined attributes

authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:933540] Garapati, P V, 2010-08-16
crossReference	[DatabaseIdentifier:12819567] BioModels Database:BIOMD0000000525 [DatabaseIdentifier:12819569] BioModels Database:BIOMD0000000523 [DatabaseIdentifier:12819571] BioModels Database:BIOMD0000000524 [DatabaseIdentifier:12819573] BioModels Database:BIOMD0000000243 [DatabaseIdentifier:12819459] BioModels Database:BIOMD0000000407 [DatabaseIdentifier:12819575] BioModels Database:BIOMD0000000526 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883
dbId	933543
displayName	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
edited	[InstanceEdit:918228] Garapati, P V, 2010-08-02
eventOf	[Pathway:R-HSA-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-168934] MAVS interacts with RIPK1 and FADD - Homo sapiens [Reaction:R-HSA-933526] Recruitment of caspase-8 and -10 to FADD complex - Homo sapiens [Reaction:R-HSA-933523] Dimerzation of procaspase-8, procaspase-10 - Homo sapiens [Reaction:R-HSA-933532] Processing of caspases - Homo sapiens [Reaction:R-HSA-933539] Recruitment of IKK complex - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-06-13
literatureReference	[LiteratureReference:933506] Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA [LiteratureReference:933437] Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases [LiteratureReference:933435] Caspases leave the beaten track: caspase-mediated activation of NF-kappaB [LiteratureReference:177847] IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
orthologousEvent	[Pathway:R-GGA-1227739] Caspase-8 and -10 mediated induction of NF-kB - Gallus gallus
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:9013948] Measles virus [Species:5617433] Rotavirus [Species:9031716] Influenza A virus [Species:9717528] Human respiratory syncytial virus A
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-933543
summation	[Summation:933433] Fas-AssociatedDeathDomain (FADD) and receptor interacting pr...
updateTrackers	[UpdateTracker:9928460] Update Tracker - [Pathway:933543] NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 - v91:[modifyText] [UpdateTracker:9781475] Update Tracker - [Pathway:933543] NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 - v61:[updateContainedRLE] [UpdateTracker:9779429] Update Tracker - [Pathway:933543] NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 - v65:[updateContainedRLE] [UpdateTracker:9786916] Update Tracker - [Pathway:933543] NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 - v47:[modifyText]

Referrals

(updatedInstance)

[UpdateTracker:9928460] Update Tracker - [Pathway:933543] NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 - v91:[modifyText]
[UpdateTracker:9781475] Update Tracker - [Pathway:933543] NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 - v61:[updateContainedRLE]
[UpdateTracker:9779429] Update Tracker - [Pathway:933543] NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 - v65:[updateContainedRLE]
[UpdateTracker:9786916] Update Tracker - [Pathway:933543] NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 - v47:[modifyText]

(hasEvent)

[Pathway:R-HSA-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta

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