Reactome | Recruitment of TRAF6/TRAF2 to MAVS

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Recruitment of TRAF6/TRAF2 to MAVS Show undefined attributes

authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
category	binding
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:918228] Garapati, P V, 2010-08-02
dbId	918230
displayName	Recruitment of TRAF6/TRAF2 to MAVS
edited	[InstanceEdit:918228] Garapati, P V, 2010-08-02
eventOf	[Pathway:R-HSA-933541] TRAF6 mediated IRF7 activation - Homo sapiens
followingEvent	[Reaction:R-HSA-933537] Recruitment of TANK to TRAF6 - Homo sapiens [Reaction:R-HSA-933528] Interaction of MEKK1 with TRAF6 - Homo sapiens
input	[DefinedSet:R-HSA-918188] TRAF2, TRAF6 [cytosol] [Complex:R-HSA-918201] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:918176] VISA is an adapter protein required for virus-triggered IFN-beta signaling [LiteratureReference:918292] TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA
maxDepth	1
modified	[InstanceEdit:9927237] Shamovsky, Veronica, 2024-11-05
name	Recruitment of TRAF6/TRAF2 to MAVS Recruitment of TRAF6/TRAF2 to IPS-1
orthologousEvent	[BlackBoxEvent:R-GGA-1227769] TRAF6/or TRAF2 ubiquitination within dsRNA:Mda5:Ips1:Traf6/ or Traf2 complex - Gallus gallus [Reaction:R-GGA-1227775] TRAF6/or TRAF2 interacts with IPS-1 - Gallus gallus
output	[Complex:R-HSA-933467] dsRNA:DDX58/dsRNA:IFIH1:MAVS:TRAF2/TRAF6 [mitochondrial outer membrane]
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:9013948] Measles virus [Species:5617433] Rotavirus [Species:9031716] Influenza A virus [Species:9717528] Human respiratory syncytial virus A
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-918230
summation	[Summation:918169] Mitochondrial antiviral-signaling protein (MAVS or IPS-1) in...
updateTrackers	[UpdateTracker:9928526] Update Tracker - [Reaction:918230] Recruitment of TRAF6/TRAF2 to MAVS - v91:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9928526] Update Tracker - [Reaction:918230] Recruitment of TRAF6/TRAF2 to MAVS - v91:[modifyText]
(hasEvent)	[Pathway:R-HSA-933541] TRAF6 mediated IRF7 activation
(precedingEvent)	[Reaction:R-HSA-933537] Recruitment of TANK to TRAF6 [Reaction:R-HSA-933528] Interaction of MEKK1 with TRAF6

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