Reactome | Toll Like Receptor 3 (TLR3) Cascade

Schema > Pathway > Entries

Toll Like Receptor 3 (TLR3) Cascade Show undefined attributes

authored	[InstanceEdit:167907] Luo, F, 2005-11-10 11:23:18
created	[InstanceEdit:168183] Gillespie, ME, 2005-11-10 16:33:34
crossReference	[DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883
dbId	168164
diseasePathways	[Pathway:R-HSA-5602566] TICAM1 deficiency - HSE - Homo sapiens [Pathway:R-HSA-5602571] TRAF3 deficiency - HSE - Homo sapiens [Pathway:R-HSA-5602410] TLR3 deficiency - HSE - Homo sapiens
displayName	Toll Like Receptor 3 (TLR3) Cascade
edited	[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
eventOf	[Pathway:R-HSA-168898] Toll-like Receptor Cascades - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:261613] toll-like receptor 3 signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-168092] Viral dsRNA binds the Toll-Like Receptor 3 (TLR3) - Homo sapiens [Reaction:R-HSA-168929] Viral dsRNA:TLR3 recruits TRIF (TICAM1) - Homo sapiens [Reaction:R-HSA-9014320] SARM binds viral dsRNA:TLR3:TICAM1 - Homo sapiens [Pathway:R-HSA-9013973] TICAM1-dependent activation of IRF3/IRF7 - Homo sapiens [Pathway:R-HSA-168927] TICAM1, RIP1-mediated IKK complex recruitment - Homo sapiens [Pathway:R-HSA-9013957] TLR3-mediated TICAM1-dependent programmed cell death - Homo sapiens [Pathway:R-HSA-9014325] TICAM1,TRAF6-dependent induction of TAK1 complex - Homo sapiens [Pathway:R-HSA-445989] TAK1-dependent IKK and NF-kappa-B activation - Homo sapiens [Pathway:R-HSA-450294] MAP kinase activation - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-09-13
literatureReference	[LiteratureReference:433817] Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins [LiteratureReference:177890] Transcriptional signaling by double-stranded RNA: role of TLR3 [LiteratureReference:434120] Sensing of viral infection and activation of innate immunity by toll-like receptor 3
maxDepth	6
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Toll Like Receptor 3 (TLR3) Cascade
orthologousEvent	[Pathway:R-RNO-168164] Toll Like Receptor 3 (TLR3) Cascade - Rattus norvegicus [Pathway:R-CFA-168164] Toll Like Receptor 3 (TLR3) Cascade - Canis familiaris [Pathway:R-BTA-168164] Toll Like Receptor 3 (TLR3) Cascade - Bos taurus [Pathway:R-SSC-168164] Toll Like Receptor 3 (TLR3) Cascade - Sus scrofa [Pathway:R-DRE-168164] Toll Like Receptor 3 (TLR3) Cascade - Danio rerio [Pathway:R-XTR-168164] Toll Like Receptor 3 (TLR3) Cascade - Xenopus tropicalis [Pathway:R-GGA-168164] Toll Like Receptor 3 (TLR3) Cascade - Gallus gallus [Pathway:R-DME-168164] Toll Like Receptor 3 (TLR3) Cascade - Drosophila melanogaster [Pathway:R-CEL-168164] Toll Like Receptor 3 (TLR3) Cascade - Caenorhabditis elegans [Pathway:R-DDI-168164] Toll Like Receptor 3 (TLR3) Cascade - Dictyostelium discoideum [Pathway:R-SPO-168164] Toll Like Receptor 3 (TLR3) Cascade - Schizosaccharomyces pombe [Pathway:R-SCE-168164] Toll Like Receptor 3 (TLR3) Cascade - Saccharomyces cerevisiae [Pathway:R-PFA-168164] Toll Like Receptor 3 (TLR3) Cascade - Plasmodium falciparum [Pathway:R-MMU-168164] Toll Like Receptor 3 (TLR3) Cascade - Mus musculus
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
releaseDate	2006-04-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17
revised	[InstanceEdit:442879] Shamovsky, V, 2009-09-29
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-168164
summation	[Summation:450220] Toll-like receptor 3 (TLR3) as was shown for mammals is expr...
updateTrackers	[UpdateTracker:9790849] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v32:[addLiteratureReference, add_removeSummation, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9788716] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v41:[add_removeHasEvent, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9792452] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v21:[updateIndirectRLE] [UpdateTracker:9864202] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v88:[modifyText, updateContainedPathway] [UpdateTracker:9788846] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v40:[updateContainedRLE] [UpdateTracker:9846664] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v84:[updateContainedPathway] [UpdateTracker:9790769] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v33:[updateContainedPathway] [UpdateTracker:9778912] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v67:[updateContainedPathway] [UpdateTracker:9774957] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v80:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9787317] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v45:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9790112] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v35:[updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9774703] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v81:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9789579] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v37:[updateContainedRLE] [UpdateTracker:9784301] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v54:[updateContainedRLE] [UpdateTracker:9842351] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v86:[modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9788297] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v43:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9782727] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v58:[updateIndirectRLE] [UpdateTracker:9779890] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v64:[updateContainedRLE] [UpdateTracker:9775816] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v78:[updateIndirectRLE] [UpdateTracker:9779352] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v65:[updateIndirectRLE] [UpdateTracker:9790207] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v34:[updateIndirectRLE] [UpdateTracker:9780772] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v62:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9778218] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v68:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9789193] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v38:[add_removeHasEvent]

Referrals

(hasEvent)	[Pathway:R-HSA-168898] Toll-like Receptor Cascades
(normalPathway)	[Pathway:R-HSA-5602566] TICAM1 deficiency - HSE [Pathway:R-HSA-5602571] TRAF3 deficiency - HSE [Pathway:R-HSA-5602410] TLR3 deficiency - HSE
(updatedInstance)	[UpdateTracker:9790849] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v32:[addLiteratureReference, add_removeSummation, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9788716] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v41:[add_removeHasEvent, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9792452] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v21:[updateIndirectRLE] [UpdateTracker:9864202] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v88:[modifyText, updateContainedPathway] [UpdateTracker:9788846] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v40:[updateContainedRLE] [UpdateTracker:9846664] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v84:[updateContainedPathway] [UpdateTracker:9790769] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v33:[updateContainedPathway] [UpdateTracker:9778912] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v67:[updateContainedPathway] [UpdateTracker:9774957] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v80:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9787317] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v45:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9790112] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v35:[updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9774703] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v81:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9789579] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v37:[updateContainedRLE] [UpdateTracker:9784301] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v54:[updateContainedRLE] [UpdateTracker:9842351] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v86:[modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9788297] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v43:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9782727] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v58:[updateIndirectRLE] [UpdateTracker:9779890] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v64:[updateContainedRLE] [UpdateTracker:9775816] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v78:[updateIndirectRLE] [UpdateTracker:9779352] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v65:[updateIndirectRLE] [UpdateTracker:9790207] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v34:[updateIndirectRLE] [UpdateTracker:9780772] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v62:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9778218] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v68:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9789193] Update Tracker - [Pathway:168164] Toll Like Receptor 3 (TLR3) Cascade - v38:[add_removeHasEvent]

Cite Us!