Reactome | IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3

Schema > Reaction > Entries

IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 Show undefined attributes

authored	[InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15
category	binding
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:9013993] Shamovsky, Veronica, 2017-07-26
dbId	9013979
displayName	IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3
edited	[InstanceEdit:5483109] Shamovsky, V, 2014-05-16
eventOf	[Pathway:R-HSA-9013973] TICAM1-dependent activation of IRF3/IRF7 - Homo sapiens
followingEvent	[Reaction:R-HSA-9013978] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex - Homo sapiens
input	[Complex:R-HSA-9013982] activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] 2 × [DefinedSet:R-HSA-450317] IRF3,IRF7 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:165917] The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection [LiteratureReference:166253] Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation [LiteratureReference:165924] Identification of Ser-386 of interferon regulatory factor 3 as critical [LiteratureReference:2569068] SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production
modified	[InstanceEdit:9862120] Shamovsky, Veronica, 2024-02-23
name	IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3
output	[Complex:R-HSA-9013981] activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane]
precedingEvent	[Reaction:R-HSA-9830706] IKK? (IKBKE) is phosphorylated within the activated TLR3 complex - Homo sapiens [Reaction:R-HSA-9828205] TBK1 is phosphorylated within the activated TLR3 complex - Homo sapiens
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17 [InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13 [InstanceEdit:5483106] Masci, Anna Maria, 2014-05-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9013979
summation	[Summation:9013975] Two members of the interferon regulatory factor (IRF) family... [Summation:9013991] SH2-containing protein tyrosine phosphatase 2 (SHP-2) has be...

Referrals

(precedingEvent)	[Reaction:R-HSA-9013978] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex
(hasEvent)	[Pathway:R-HSA-9013973] TICAM1-dependent activation of IRF3/IRF7