Reactome | viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane]

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viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane] Show undefined attributes

catalystActivities	[CatalystActivity:450212] MAP kinase kinase kinase kinase activity of viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane]
compartment	[Compartment:74700] endosome membrane
consumedByEvent	[Reaction:R-HSA-177692] Activation of recruited TAK1 within the activated TLR3 complex - Homo sapiens
created	[InstanceEdit:177688] Gillespie, ME, 2006-04-04 05:49:12
dbId	177689
displayName	viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane]
hasComponent	2 × [Polymer:R-HSA-450271] K63polyUb [endosome membrane] 2 × [EntityWithAccessionedSequence:R-HSA-450315] MAP3K7 [endosome membrane] 2 × [EntityWithAccessionedSequence:R-HSA-450238] TAB1 [endosome membrane] 2 × [DefinedSet:R-HSA-975101] TAB2/3 [endosome membrane] [Complex:R-HSA-450309] viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane]
inDisease	false
includedLocation	[Compartment:171907] endosome lumen
literatureReference	[LiteratureReference:177899] Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR [LiteratureReference:433849] Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation
maxDepth	6
modified	[InstanceEdit:9031727] D'Eustachio, Peter, 2017-12-01
name	viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain
producedByEvent	[Reaction:R-HSA-177690] Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex - Homo sapiens
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-177689
updateTrackers	[UpdateTracker:9870991] Update Tracker - [Complex:177689] viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane] - v39:[updateContainedComponent] [UpdateTracker:9869694] Update Tracker - [Complex:177689] viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane] - v34:[updateContainedComponent] [UpdateTracker:9898570] Update Tracker - [Complex:177689] viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane] - v64:[updateContainedComponent] [UpdateTracker:9898247] Update Tracker - [Complex:177689] viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane] - v63:[updateContainedComponent] [UpdateTracker:9869905] Update Tracker - [Complex:177689] viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane] - v35:[add_removeHasComponent, modifyName] [UpdateTracker:9870504] Update Tracker - [Complex:177689] viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane] - v38:[modifyName, updateContainedComponent] [UpdateTracker:9868700] Update Tracker - [Complex:177689] viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane] - v32:[add_removeCompartment, add_removeHasComponent, modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9870991] Update Tracker - [Complex:177689] viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane] - v39:[updateContainedComponent] [UpdateTracker:9869694] Update Tracker - [Complex:177689] viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane] - v34:[updateContainedComponent] [UpdateTracker:9898570] Update Tracker - [Complex:177689] viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane] - v64:[updateContainedComponent] [UpdateTracker:9898247] Update Tracker - [Complex:177689] viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane] - v63:[updateContainedComponent] [UpdateTracker:9869905] Update Tracker - [Complex:177689] viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane] - v35:[add_removeHasComponent, modifyName] [UpdateTracker:9870504] Update Tracker - [Complex:177689] viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane] - v38:[modifyName, updateContainedComponent] [UpdateTracker:9868700] Update Tracker - [Complex:177689] viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane] - v32:[add_removeCompartment, add_removeHasComponent, modifyName]
(output)	[Reaction:R-HSA-177690] Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex
(input)	[Reaction:R-HSA-177692] Activation of recruited TAK1 within the activated TLR3 complex
(physicalEntity)	[CatalystActivity:450212] MAP kinase kinase kinase kinase activity of viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane]

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