Reactome | K63-linked ubiquitination of RIP1 bound to the activated TLR complex

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K63-linked ubiquitination of RIP1 bound to the activated TLR complex Show undefined attributes

authored	[InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15
catalystActivity	[CatalystActivity:2569080] ubiquitin-protein transferase activity of RIP1 ubiqutin ligases [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:9014345] Shamovsky, Veronica, 2017-07-28
dbId	9014342
displayName	K63-linked ubiquitination of RIP1 bound to the activated TLR complex
edited	[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
eventOf	[Pathway:R-HSA-168927] TICAM1, RIP1-mediated IKK complex recruitment - Homo sapiens
input	2 × [Polymer:R-HSA-450152] K63polyUb [cytosol] [Complex:R-HSA-177649] viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:451562] Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO [LiteratureReference:165954] RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B [LiteratureReference:2569072] cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	K63-linked ubiquitination of RIP1 bound to the activated TLR complex
output	[Complex:R-HSA-9014344] activated TLR3:TICAM1:K63pUb-RIP1 [endosome membrane]
precedingEvent	[Reaction:R-HSA-168930] Viral dsRNA:TLR3:TRIF complex recruits RIP1 - Homo sapiens
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17 [InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9014342
summation	[Summation:939839] RIP1 polyubiquitination was induced upon TNF- or poly(I-C) t...

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(hasEvent)

[Pathway:R-HSA-168927] TICAM1, RIP1-mediated IKK complex recruitment

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