Reactome | activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane]

Schema > Complex > Entries

activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] Show undefined attributes

compartment	[Compartment:74700] endosome membrane
componentOf	[Complex:R-HSA-9013981] activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9013979] IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 - Homo sapiens
created	[InstanceEdit:9013993] Shamovsky, Veronica, 2017-07-26
dbId	9013982
displayName	activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane]
hasComponent	[Complex:R-HSA-9013976] K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] [DefinedSet:R-HSA-9730454] p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:171907] endosome lumen
isChimeric	false
literatureReference	[LiteratureReference:918164] Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response [LiteratureReference:2423829] Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling [LiteratureReference:933507] SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways
modified	[InstanceEdit:9823897] Shamovsky, Veronica, 2023-01-12
name	activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE
producedByEvent	[Reaction:R-HSA-9013978] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex - Homo sapiens
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9013982

Referrals

(output)	[Reaction:R-HSA-9013978] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex
(hasComponent)	[Complex:R-HSA-9013981] activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane]
(input)	[Reaction:R-HSA-9013979] IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3

© 2024 Reactome

Cite Us!