Reactome | TRAF6 mediated IRF7 activation

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TRAF6 mediated IRF7 activation Show undefined attributes

authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:933540] Garapati, P V, 2010-08-16
dbId	933541
displayName	TRAF6 mediated IRF7 activation
edited	[InstanceEdit:918228] Garapati, P V, 2010-08-02
eventOf	[Pathway:R-HSA-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-918230] Recruitment of TRAF6/TRAF2 to MAVS - Homo sapiens [Reaction:R-HSA-933537] Recruitment of TANK to TRAF6 - Homo sapiens [Reaction:R-HSA-933527] Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 - Homo sapiens [Reaction:R-HSA-9705145] TBK1, IKBKE form homodimers - Homo sapiens [Reaction:R-HSA-9705323] Phosphorylation of TBK1/IKBKE - Homo sapiens [Reaction:R-HSA-933538] Recruitment of IRF7 to TRAF6 - Homo sapiens [Reaction:R-HSA-933525] Phosphorylation and release of IRF7 - Homo sapiens [Reaction:R-HSA-933533] Dimerization of p-IRF7 - Homo sapiens [Reaction:R-HSA-933531] Translocation of p-IRF7:p-IRF7 to nucleus - Homo sapiens [Reaction:R-HSA-933536] p-IRF7 dimer interacts with coactivator CBP/p300 - Homo sapiens [Reaction:R-HSA-1028820] Formation of VAF (virus-activated factor) complex - Homo sapiens [Reaction:R-HSA-1028819] VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes - Homo sapiens [BlackBoxEvent:R-HSA-9604499] Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-03-24
literatureReference	[LiteratureReference:918292] TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA
maxDepth	2
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	TRAF6 mediated IRF7 activation
orthologousEvent	[Pathway:R-GGA-933541] TRAF6 mediated IRF7 activation - Gallus gallus [Pathway:R-XTR-933541] TRAF6 mediated IRF7 activation - Xenopus tropicalis [Pathway:R-DRE-933541] TRAF6 mediated IRF7 activation - Danio rerio [Pathway:R-SSC-933541] TRAF6 mediated IRF7 activation - Sus scrofa [Pathway:R-BTA-933541] TRAF6 mediated IRF7 activation - Bos taurus [Pathway:R-RNO-933541] TRAF6 mediated IRF7 activation - Rattus norvegicus [Pathway:R-MMU-933541] TRAF6 mediated IRF7 activation - Mus musculus [Pathway:R-GGA-1227882] TRAF mediated activation of IRF - Gallus gallus
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:9013948] Measles virus [Species:5617433] Rotavirus [Species:9031716] Influenza A virus [Species:9717528] Human respiratory syncytial virus A
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-933541
summation	[Summation:933431] TRAF6 is crucial for both DDX58 (RIG-I)- and IFIH1 (MDA5)-me...
updateTrackers	[UpdateTracker:9788070] Update Tracker - [Pathway:933541] TRAF6 mediated IRF7 activation - v44:[updateContainedRLE] [UpdateTracker:9776452] Update Tracker - [Pathway:933541] TRAF6 mediated IRF7 activation - v76:[addHasEvent, updateContainedRLE] [UpdateTracker:9928443] Update Tracker - [Pathway:933541] TRAF6 mediated IRF7 activation - v91:[modifyText] [UpdateTracker:9779394] Update Tracker - [Pathway:933541] TRAF6 mediated IRF7 activation - v65:[add_removeHasEvent, updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9788070] Update Tracker - [Pathway:933541] TRAF6 mediated IRF7 activation - v44:[updateContainedRLE]
[UpdateTracker:9776452] Update Tracker - [Pathway:933541] TRAF6 mediated IRF7 activation - v76:[addHasEvent, updateContainedRLE]
[UpdateTracker:9928443] Update Tracker - [Pathway:933541] TRAF6 mediated IRF7 activation - v91:[modifyText]
[UpdateTracker:9779394] Update Tracker - [Pathway:933541] TRAF6 mediated IRF7 activation - v65:[add_removeHasEvent, updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta

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