Reactome | Recruitment of IRF3,IRF7

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Recruitment of IRF3,IRF7 Show undefined attributes

authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
category	binding
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:918228] Garapati, P V, 2010-08-02
dbId	918232
displayName	Recruitment of IRF3,IRF7
edited	[InstanceEdit:918228] Garapati, P V, 2010-08-02
eventOf	[Pathway:R-HSA-918233] TRAF3-dependent IRF activation pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-918229] Phosphorylation and release of IRF3/IRF7 - Homo sapiens
input	[DefinedSet:R-HSA-450317] IRF3,IRF7 [cytosol] [Complex:R-HSA-9710999] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:166859] IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway [LiteratureReference:918176] VISA is an adapter protein required for virus-triggered IFN-beta signaling [LiteratureReference:918216] Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages
maxDepth	1
modified	[InstanceEdit:9835846] Shamovsky, Veronica, 2023-05-18
name	Recruitment of IRF3,IRF7
orthologousEvent	[Reaction:R-GGA-1227863] Recruitment of IRF to activated TBK1/IKK epsilon - Gallus gallus
output	[Complex:R-HSA-918199] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xTBK1,IKBKE:IRF3,IRF7 [mitochondrial outer membrane]
precedingEvent	[Reaction:R-HSA-918225] TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 - Homo sapiens
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:9013948] Measles virus [Species:5617433] Rotavirus [Species:9031716] Influenza A virus [Species:9717528] Human respiratory syncytial virus A
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-918232
summation	[Summation:918168] IRF3 and IRF7 (IRF3/IRF7) are the two major members of the i...
updateTrackers	[UpdateTracker:9928470] Update Tracker - [Reaction:918232] Recruitment of IRF3,IRF7 - v91:[modifyText] [UpdateTracker:9776459] Update Tracker - [Reaction:918232] Recruitment of IRF3,IRF7 - v76:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9928470] Update Tracker - [Reaction:918232] Recruitment of IRF3,IRF7 - v91:[modifyText] [UpdateTracker:9776459] Update Tracker - [Reaction:918232] Recruitment of IRF3,IRF7 - v76:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-918233] TRAF3-dependent IRF activation pathway
(precedingEvent)	[Reaction:R-HSA-918229] Phosphorylation and release of IRF3/IRF7