Reactome | activated TLR3:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane]

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activated TLR3:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] Show undefined attributes

catalystActivities	[CatalystActivity:9013890] cysteine-type endopeptidase activity of activated TLR3:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane]
compartment	[Compartment:74700] endosome membrane
consumedByEvent	[Reaction:R-HSA-9013895] Caspase-8 processing within TLR3 complex - Homo sapiens
created	[InstanceEdit:9013896] Shamovsky, Veronica, 2017-07-26
dbId	9013891
displayName	activated TLR3:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane]
hasComponent	2 × [EntityWithAccessionedSequence:R-HSA-57031] CASP8(1-479) [cytosol] 2 × [EntityWithAccessionedSequence:R-HSA-54639] FADD [cytosol] 2 × [EntityWithAccessionedSequence:R-HSA-168651] RIPK1 [cytosol] [Complex:R-HSA-168907] viral dsRNA:TLR3:TICAM1 [endosome membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:171907] endosome lumen
literatureReference	[LiteratureReference:2562571] dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8 [LiteratureReference:433849] Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation [LiteratureReference:936978] Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif [LiteratureReference:2562551] cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms
modified	[InstanceEdit:9031727] D'Eustachio, Peter, 2017-12-01
name	activated TLR3:TRIF:RIP1:FADD:pro-caspase-8
producedByEvent	[Reaction:R-HSA-9013889] TLR3-induced ripoptosome assembly - Homo sapiens
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9013891

Referrals

(output)	[Reaction:R-HSA-9013889] TLR3-induced ripoptosome assembly
(input)	[Reaction:R-HSA-9013895] Caspase-8 processing within TLR3 complex
(physicalEntity)	[CatalystActivity:9013890] cysteine-type endopeptidase activity of activated TLR3:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane]

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