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Schema
>
BlackBoxEvent
>
Entries
TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3
Show undefined attributes
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authored
[InstanceEdit:9828202] Shamovsky, Veronica, 2023-02-10
category
omitted
compartment
[Compartment:74700] endosome membrane
[Compartment:70101] cytosol
created
[InstanceEdit:9828202] Shamovsky, Veronica, 2023-02-10
dbId
9828200
displayName
TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3
edited
[InstanceEdit:9863258] Shamovsky, Veronica, 2024-02-28
eventOf
[Pathway:R-HSA-9828211] Regulation of TBK1, IKK?-mediated activation of IRF3, IRF7 upon TLR3 ligation - Homo sapiens
input
[Complex:R-HSA-9828199] TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane]
3 ×
[DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:433880] Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes
[LiteratureReference:5362581] Crystal structure and mechanism of activation of TANK-binding kinase 1
[LiteratureReference:5362611] Structure and ubiquitination-dependent activation of TANK-binding kinase 1
[LiteratureReference:9705328] IKK?-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex
maxDepth
1
modified
[InstanceEdit:9863521] Shamovsky, Veronica, 2024-03-01
name
TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3
TBK1 is ubiquitinated within the activated TLR3 complex
output
[Complex:R-HSA-9830705] K63polyUb-TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane]
precedingEvent
[Reaction:R-HSA-9828196] TBK1 binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 - Homo sapiens
relatedSpecies
[Species:5229092] Hepatitis B virus
[Species:5621375] Hepatitis C Virus
[Species:5689680] Human herpesvirus 1
[Species:5617433] Rotavirus
[Species:9031716] Influenza A virus
releaseDate
2024-03-27
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9863280] Muniti?, Ivana, Franjki?, Toni, 2024-02-28
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-9828200
summation
[Summation:9830709] Pathogen?associated inflammatory signaling pathways result i...
Referrals
(hasEvent)
[Pathway:R-HSA-9828211] Regulation of TBK1, IKK?-mediated activation of IRF3, IRF7 upon TLR3 ligation
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