Reactome | Processing of caspases

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Processing of caspases Show undefined attributes

authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
catalystActivity	[CatalystActivity:992767] cysteine-type endopeptidase activity of viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521) [mitochondrial outer membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:933535] Garapati, P V, 2010-08-16
dbId	933532
displayName	Processing of caspases
edited	[InstanceEdit:918228] Garapati, P V, 2010-08-02
eventOf	[Pathway:R-HSA-933543] NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 - Homo sapiens
followingEvent	[Reaction:R-HSA-933539] Recruitment of IKK complex - Homo sapiens
input	[Complex:R-HSA-933483] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521) [mitochondrial outer membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:141306] Caspase-10 is an initiator caspase in death receptor signaling [LiteratureReference:933437] Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases [LiteratureReference:933435] Caspases leave the beaten track: caspase-mediated activation of NF-kappaB [LiteratureReference:933511] Non-apoptotic functions of caspase-8 [LiteratureReference:933506] Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA
maxDepth	1
modified	[InstanceEdit:9835843] Shamovsky, Veronica, 2023-05-18
name	Processing of caspases
output	2 × [EntityWithAccessionedSequence:R-HSA-933458] CASP10(220-415) [cytosol] 2 × [EntityWithAccessionedSequence:R-HSA-933455] CASP10(416-521) [cytosol] 2 × [EntityWithAccessionedSequence:R-HSA-75975] CASP8(217-374) [cytosol] 2 × [EntityWithAccessionedSequence:R-HSA-933460] CASP8(375-384) [cytosol] 2 × [EntityWithAccessionedSequence:R-HSA-76158] CASP8(385-479) [cytosol] [Complex:R-HSA-8983916] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-216), CASP10(1-219) [mitochondrial outer membrane]
precedingEvent	[Reaction:R-HSA-933523] Dimerzation of procaspase-8, procaspase-10 - Homo sapiens
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:9013948] Measles virus [Species:5617433] Rotavirus [Species:9031716] Influenza A virus [Species:9717528] Human respiratory syncytial virus A
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-933532
summation	[Summation:933419] Processing of caspases is required for activation of downstr...
updateTrackers	[UpdateTracker:9781018] Update Tracker - [Reaction:933532] Processing of caspases - v61:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9781018] Update Tracker - [Reaction:933532] Processing of caspases - v61:[add_removeOutput]
(precedingEvent)	[Reaction:R-HSA-933539] Recruitment of IKK complex
(hasEvent)	[Pathway:R-HSA-933543] NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10