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Reaction
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Entries
Processing of caspases
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authored
[InstanceEdit:918228] Garapati, P V, 2010-08-02
catalystActivity
[CatalystActivity:992767] cysteine-type endopeptidase activity of viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521) [mitochondrial outer membrane]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:17906] mitochondrial outer membrane
created
[InstanceEdit:933535] Garapati, P V, 2010-08-16
dbId
933532
displayName
Processing of caspases
edited
[InstanceEdit:918228] Garapati, P V, 2010-08-02
eventOf
[Pathway:R-HSA-933543] NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 - Homo sapiens
followingEvent
[Reaction:R-HSA-933539] Recruitment of IKK complex - Homo sapiens
input
[Complex:R-HSA-933483] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521) [mitochondrial outer membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:141306] Caspase-10 is an initiator caspase in death receptor signaling
[LiteratureReference:933437] Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases
[LiteratureReference:933435] Caspases leave the beaten track: caspase-mediated activation of NF-kappaB
[LiteratureReference:933511] Non-apoptotic functions of caspase-8
[LiteratureReference:933506] Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA
modified
[InstanceEdit:9835843] Shamovsky, Veronica, 2023-05-18
name
Processing of caspases
output
2 ×
[EntityWithAccessionedSequence:R-HSA-933458] CASP10(220-415) [cytosol]
2 ×
[EntityWithAccessionedSequence:R-HSA-933455] CASP10(416-521) [cytosol]
2 ×
[EntityWithAccessionedSequence:R-HSA-75975] CASP8(217-374) [cytosol]
2 ×
[EntityWithAccessionedSequence:R-HSA-933460] CASP8(375-384) [cytosol]
2 ×
[EntityWithAccessionedSequence:R-HSA-76158] CASP8(385-479) [cytosol]
[Complex:R-HSA-8983916] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-216), CASP10(1-219) [mitochondrial outer membrane]
precedingEvent
[Reaction:R-HSA-933523] Dimerzation of procaspase-8, procaspase-10 - Homo sapiens
relatedSpecies
[Species:5621375] Hepatitis C Virus
[Species:9013948] Measles virus
[Species:5617433] Rotavirus
[Species:9031716] Influenza A virus
[Species:9717528] Human respiratory syncytial virus A
releaseDate
2010-12-14
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-933532
summation
[Summation:933419] Processing of caspases is required for activation of downstr...
Referrals
(precedingEvent)
[Reaction:R-HSA-933539] Recruitment of IKK complex
(hasEvent)
[Pathway:R-HSA-933543] NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
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