Reactome | Viral dsRNA:TLR3:TRIF complex recruits RIP1

Schema > Reaction > Entries

Viral dsRNA:TLR3:TRIF complex recruits RIP1 Show undefined attributes

authored	[InstanceEdit:167907] Luo, F, 2005-11-10 11:23:18
category	binding
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:168919] de Bono, B, 2005-11-22 18:36:47
dbId	168930
deleted	[Deleted:765400] Deletion of instance: 168911
displayName	Viral dsRNA:TLR3:TRIF complex recruits RIP1
edited	[InstanceEdit:450361] Shamovsky, V, 2009-12-16
eventOf	[Pathway:R-HSA-168927] TICAM1, RIP1-mediated IKK complex recruitment - Homo sapiens
followingEvent	[Reaction:R-HSA-9014342] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - Homo sapiens [Reaction:R-HSA-168910] RIP1 facilitates IKK complex phosphorylation - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-168651] RIPK1 [cytosol] [Complex:R-HSA-168907] viral dsRNA:TLR3:TICAM1 [endosome membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:165954] RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B [LiteratureReference:433849] Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Viral dsRNA:TLR3:TRIF complex recruits RIP1
output	[Complex:R-HSA-177649] viral dsRNA:TLR3:TICAM1:RIPK1 [endosome membrane]
precedingEvent	[Reaction:R-HSA-168929] Viral dsRNA:TLR3 recruits TRIF (TICAM1) - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-450301] Negative regulation by 'RIPK3 [cytosol]'
regulationReference	[RegulationReference:9642297] Negative regulation by 'RIPK3 [cytosol]' RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17
revised	[InstanceEdit:442879] Shamovsky, V, 2009-09-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-168930
summation	[Summation:433930] RIP1 is recruited to the activated TLR receptor by binding t...
updateTrackers	[UpdateTracker:9790255] Update Tracker - [Reaction:168930] Viral dsRNA:TLR3:TRIF complex recruits RIP1 - v34:[modifyText] [UpdateTracker:9790111] Update Tracker - [Reaction:168930] Viral dsRNA:TLR3:TRIF complex recruits RIP1 - v35:[modifyText] [UpdateTracker:9791016] Update Tracker - [Reaction:168930] Viral dsRNA:TLR3:TRIF complex recruits RIP1 - v32:[addLiteratureReference, addRegulator, add_removeSummation]

Referrals

(updatedInstance)	[UpdateTracker:9790255] Update Tracker - [Reaction:168930] Viral dsRNA:TLR3:TRIF complex recruits RIP1 - v34:[modifyText] [UpdateTracker:9790111] Update Tracker - [Reaction:168930] Viral dsRNA:TLR3:TRIF complex recruits RIP1 - v35:[modifyText] [UpdateTracker:9791016] Update Tracker - [Reaction:168930] Viral dsRNA:TLR3:TRIF complex recruits RIP1 - v32:[addLiteratureReference, addRegulator, add_removeSummation]
(replacementInstances)	[Deleted:765400] Deletion of instance: 168911
(precedingEvent)	[Reaction:R-HSA-9014342] K63-linked ubiquitination of RIP1 bound to the activated TLR complex [Reaction:R-HSA-168910] RIP1 facilitates IKK complex phosphorylation
(hasEvent)	[Pathway:R-HSA-168927] TICAM1, RIP1-mediated IKK complex recruitment