Reactome | Recruitment of TANK to TRAF6

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Recruitment of TANK to TRAF6 Show undefined attributes

authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
category	binding
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:933535] Garapati, P V, 2010-08-16
dbId	933537
displayName	Recruitment of TANK to TRAF6
edited	[InstanceEdit:918228] Garapati, P V, 2010-08-02
eventOf	[Pathway:R-HSA-933541] TRAF6 mediated IRF7 activation - Homo sapiens
followingEvent	[Reaction:R-HSA-933527] Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 - Homo sapiens
input	[Complex:R-HSA-933467] dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6 [mitochondrial outer membrane] [EntityWithAccessionedSequence:R-HSA-933407] TANK [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:918292] TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA [LiteratureReference:933499] TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis [LiteratureReference:933515] Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK
modified	[InstanceEdit:9835847] Shamovsky, Veronica, 2023-05-18
name	Recruitment of TANK to TRAF6
orthologousEvent	[Reaction:R-GGA-1227867] TANK binds polyubiquitinated TRAF3/6 - Gallus gallus
output	[Complex:R-HSA-933472] dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK [mitochondrial outer membrane]
precedingEvent	[Reaction:R-HSA-918230] Recruitment of TRAF6/TRAF2 to IPS-1 - Homo sapiens
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:9013948] Measles virus [Species:5617433] Rotavirus [Species:9031716] Influenza A virus [Species:9717528] Human respiratory syncytial virus A
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-933537
summation	[Summation:933445] TRAF family member-associated NF-kB activator (TANK, also kn...

Referrals

(hasEvent)	[Pathway:R-HSA-933541] TRAF6 mediated IRF7 activation
(precedingEvent)	[Reaction:R-HSA-933527] Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6