Reactome | viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane]

Schema > Complex > Entries

viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane] Show undefined attributes

compartment	[Compartment:74700] endosome membrane
consumedByEvent	[BlackBoxEvent:R-HSA-450259] Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex - Homo sapiens
created	[InstanceEdit:177688] Gillespie, ME, 2006-04-04 05:49:12
dbId	177693
displayName	viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane]
hasComponent	[EntityWithAccessionedSequence:R-HSA-450272] TRAF6 [endosome membrane] [Complex:R-HSA-168907] viral dsRNA:TLR3:TICAM1 [endosome membrane]
inDisease	false
includedLocation	[Compartment:171907] endosome lumen
literatureReference	[LiteratureReference:500568] Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway [LiteratureReference:2428862] Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta [LiteratureReference:433849] Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation [LiteratureReference:433920] Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
maxDepth	5
modified	[InstanceEdit:9031727] D'Eustachio, Peter, 2017-12-01
name	viral dsRNA:TLR3:TRIF:TRAF6
producedByEvent	[Reaction:R-HSA-177694] Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6 - Homo sapiens
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-177693
updateTrackers	[UpdateTracker:9869114] Update Tracker - [Complex:177693] viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane] - v32:[add_removeCompartment, add_removeHasComponent, updateContainedComponent] [UpdateTracker:9898182] Update Tracker - [Complex:177693] viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane] - v63:[updateContainedComponent] [UpdateTracker:9898969] Update Tracker - [Complex:177693] viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane] - v64:[updateContainedComponent] [UpdateTracker:9871070] Update Tracker - [Complex:177693] viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane] - v39:[updateContainedComponent] [UpdateTracker:9870552] Update Tracker - [Complex:177693] viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane] - v38:[modifyName, updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9869114] Update Tracker - [Complex:177693] viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane] - v32:[add_removeCompartment, add_removeHasComponent, updateContainedComponent] [UpdateTracker:9898182] Update Tracker - [Complex:177693] viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane] - v63:[updateContainedComponent] [UpdateTracker:9898969] Update Tracker - [Complex:177693] viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane] - v64:[updateContainedComponent] [UpdateTracker:9871070] Update Tracker - [Complex:177693] viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane] - v39:[updateContainedComponent] [UpdateTracker:9870552] Update Tracker - [Complex:177693] viral dsRNA:TLR3:TRIF:TRAF6 [endosome membrane] - v38:[modifyName, updateContainedComponent]
(output)	[Reaction:R-HSA-177694] Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6
(input)	[BlackBoxEvent:R-HSA-450259] Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex

© 2026 Reactome

Cite Us!