Reactome | OPTN:TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane]

Schema > Complex > Entries

compartment	[Compartment:74700] endosome membrane
created	[InstanceEdit:9828202] Shamovsky, Veronica, 2023-02-10
dbId	9828198
displayName	OPTN:TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane]
hasComponent	[EntityWithAccessionedSequence:R-HSA-9687907] OPTN [cytosol] [Complex:R-HSA-9828199] TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:171907] endosome lumen
isChimeric	false
maxDepth	8
modified	[InstanceEdit:9863517] Shamovsky, Veronica, 2024-03-01
name	OPTN:TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3
positivelyRegulates	[PositiveRegulation:9828206] Positive regulation by 'OPTN:TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane]'
producedByEvent	[Reaction:R-HSA-9828209] OPTN binds TBK1 within the activated TLR3 complex - Homo sapiens
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9828198

(regulator)	[PositiveRegulation:9828206] Positive regulation by 'OPTN:TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane]'
(output)	[Reaction:R-HSA-9828209] OPTN binds TBK1 within the activated TLR3 complex

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