Reactome | RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis

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RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis Show undefined attributes

authored	[InstanceEdit:2248861] Shamovsky, V, 2012-05-15
category	transition
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:9013964] Shamovsky, Veronica, 2017-07-26
dbId	9013963
displayName	RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis
edited	[InstanceEdit:2603274] Shamovsky, V, 2012-11-19
eventOf	[Pathway:R-HSA-9013957] TLR3-mediated TICAM1-dependent programmed cell death - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:396762] necroptotic process
input	4 × [EntityWithAccessionedSequence:R-HSA-450328] RIPK3 [cytosol] [CandidateSet:R-HSA-9013962] TICAM1:activated TLR3 complexes [endosome membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2584548] Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA [LiteratureReference:2584557] Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway [LiteratureReference:2562551] cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms [LiteratureReference:936978] Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis
output	[CandidateSet:R-HSA-9013956] RIP3:TICAM1:activated TLR3 [endosome membrane]
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9013963
summation	[Summation:2584542] TLR3 and TLR4 -directed programmed necrosis (necroptosis) is...

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(hasEvent)

[Pathway:R-HSA-9013957] TLR3-mediated TICAM1-dependent programmed cell death

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