Reactome | TBK1 or IKBKE forms homodimers

Schema > Reaction > Entries

TBK1 or IKBKE forms homodimers Show undefined attributes

authored	[InstanceEdit:9710238] Shamovsky, Veronica, 2020-12-25
category	binding
compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:9705126] Shamovsky, Veronica, 2020-10-21
dbId	9705137
displayName	TBK1 or IKBKE forms homodimers
edited	[InstanceEdit:9716568] Shamovsky, Veronica, 2021-02-22
eventOf	[Pathway:R-HSA-918233] TRAF3-dependent IRF activation pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-9705320] TBK1, IKBKE are autophosphorylated at Ser172 - Homo sapiens
input	[DefinedSet:R-HSA-450329] TBK1, IKBKE [cytosol] [Complex:R-HSA-918196] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:TBK1/IKBKE [mitochondrial outer membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5362581] Crystal structure and mechanism of activation of TANK-binding kinase 1 [LiteratureReference:9705131] Functionally distinct effects of the C-terminal regions of IKK? and TBK1 on type I IFN production [LiteratureReference:2408458] Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation
maxDepth	1
modified	[InstanceEdit:9835850] Shamovsky, Veronica, 2023-05-18
name	TBK1 or IKBKE forms homodimers
output	[Complex:R-HSA-9705133] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xIKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane]
precedingEvent	[Reaction:R-HSA-918225] TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 - Homo sapiens
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:9013948] Measles virus [Species:5617433] Rotavirus [Species:9031716] Influenza A virus [Species:9717528] Human respiratory syncytial virus A
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9713624] D'Eustachio, Peter, 2021-01-27 [InstanceEdit:9727967] Ramos, Carlos H I, 2021-04-19
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9705137
summation	[Summation:9705127] RIG?I?like receptors (RLRs) recognize RNAs from various RNA ...
updateTrackers	[UpdateTracker:9928398] Update Tracker - [Reaction:9705137] TBK1 or IKBKE forms homodimers - v91:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9928398] Update Tracker - [Reaction:9705137] TBK1 or IKBKE forms homodimers - v91:[modifyText]
(hasEvent)	[Pathway:R-HSA-918233] TRAF3-dependent IRF activation pathway
(precedingEvent)	[Reaction:R-HSA-9705320] TBK1, IKBKE are autophosphorylated at Ser172