Reactome | TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA

Schema > BlackBoxEvent > Entries

TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA Show undefined attributes

authored	[InstanceEdit:5475178] Shamovsky, V, 2014-05-16
category	omitted
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:9013993] Shamovsky, Veronica, 2017-07-26
dbId	9013990
displayName	TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA
edited	[InstanceEdit:5483109] Shamovsky, V, 2014-05-16
eventOf	[Pathway:R-HSA-9013973] TICAM1-dependent activation of IRF3/IRF7 - Homo sapiens
followingEvent	[Reaction:R-HSA-9828196] TBK1 binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 - Homo sapiens [Reaction:R-HSA-9828204] IKK? (IKBKE) binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 - Homo sapiens
input	[Complex:R-HSA-9013980] TANK:K63-poly-Ub-TRAF3:TICAM1:viral dsRNA:TLR3 [endosome membrane] [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:202505] Regulation and function of IKK and IKK-related kinases
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:activated TLR3
output	[Complex:R-HSA-9013976] K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane]
precedingEvent	[Reaction:R-HSA-9013985] TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3 - Homo sapiens
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5483106] Masci, Anna Maria, 2014-05-16
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9013990
summation	[Summation:9013972] Upon stimulation by pathogen-associated inflammatory signals...

Referrals

(hasEvent)	[Pathway:R-HSA-9013973] TICAM1-dependent activation of IRF3/IRF7
(precedingEvent)	[Reaction:R-HSA-9828196] TBK1 binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 [Reaction:R-HSA-9828204] IKK? (IKBKE) binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3

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