Reactome | TLR3-mediated TICAM1-dependent programmed cell death

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TLR3-mediated TICAM1-dependent programmed cell death Show undefined attributes

authored	[InstanceEdit:2248861] Shamovsky, V, 2012-05-15
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:9013964] Shamovsky, Veronica, 2017-07-26
crossReference	[DatabaseIdentifier:12819567] BioModels Database:BIOMD0000000525 [DatabaseIdentifier:12819569] BioModels Database:BIOMD0000000523 [DatabaseIdentifier:12819571] BioModels Database:BIOMD0000000524 [DatabaseIdentifier:12819573] BioModels Database:BIOMD0000000243 [DatabaseIdentifier:12819459] BioModels Database:BIOMD0000000407 [DatabaseIdentifier:12819575] BioModels Database:BIOMD0000000526
dbId	9013957
displayName	TLR3-mediated TICAM1-dependent programmed cell death
edited	[InstanceEdit:2603274] Shamovsky, V, 2012-11-19
eventOf	[Pathway:R-HSA-168164] Toll Like Receptor 3 (TLR3) Cascade - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9013889] TLR3-induced ripoptosome assembly - Homo sapiens [Reaction:R-HSA-9013895] Caspase-8 processing within TLR3 complex - Homo sapiens [Reaction:R-HSA-9013963] RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:936978] Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif [LiteratureReference:2423825] Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways [LiteratureReference:2562571] dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8 [LiteratureReference:2562551] cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms [LiteratureReference:2584562] The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs [LiteratureReference:2584548] Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA [LiteratureReference:2584541] Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	TLR3-mediated TICAM1-dependent programmed cell death
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9013957
summation	[Summation:9013958] TLR3 and TLR4 trigger TRIF(TICAM1)-dependent programmed cell...

Referrals

(hasEvent)

[Pathway:R-HSA-168164] Toll Like Receptor 3 (TLR3) Cascade