Reactome | Recruitment of caspase-8 and -10 to FADD complex

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Recruitment of caspase-8 and -10 to FADD complex Show undefined attributes

authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
category	binding
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:933535] Garapati, P V, 2010-08-16
dbId	933526
displayName	Recruitment of caspase-8 and -10 to FADD complex
edited	[InstanceEdit:918228] Garapati, P V, 2010-08-02
eventOf	[Pathway:R-HSA-933543] NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 - Homo sapiens
followingEvent	[Reaction:R-HSA-933523] Dimerzation of procaspase-8, procaspase-10 - Homo sapiens
input	[DefinedSet:R-HSA-933463] CASP8(1-479), CASP10(1-521) [cytosol] [Complex:R-HSA-918291] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:933506] Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA [LiteratureReference:933437] Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases [LiteratureReference:933435] Caspases leave the beaten track: caspase-mediated activation of NF-kappaB [LiteratureReference:933511] Non-apoptotic functions of caspase-8 [LiteratureReference:933514] Regulation of Fas-associated death domain interactions by the death effector domain identified by a modified reverse two-hybrid screen [LiteratureReference:141306] Caspase-10 is an initiator caspase in death receptor signaling
maxDepth	1
modified	[InstanceEdit:9835849] Shamovsky, Veronica, 2023-05-18
name	Recruitment of caspase-8 and -10 to FADD complex
orthologousEvent	[Reaction:R-GGA-1227753] Caspase 8 or 10 recruitment to IPS1 complex followed by their dimerization - Gallus gallus
output	[Complex:R-HSA-933468] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-479), CASP10(1-521) [mitochondrial outer membrane]
precedingEvent	[Reaction:R-HSA-168934] MAVS interacts with RIPK1 and FADD - Homo sapiens [BlackBoxEvent:R-HSA-6798139] TP53 stimulates CASP10 expression - Homo sapiens
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:9013948] Measles virus [Species:5617433] Rotavirus [Species:9031716] Influenza A virus [Species:9717528] Human respiratory syncytial virus A
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-933526
summation	[Summation:933441] Caspase-8 (CASP8) and caspase-10 (CASP10) are involved in RI...
updateTrackers	[UpdateTracker:9928537] Update Tracker - [Reaction:933526] Recruitment of caspase-8 and -10 to FADD complex - v91:[modifyText] [UpdateTracker:9779530] Update Tracker - [Reaction:933526] Recruitment of caspase-8 and -10 to FADD complex - v65:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9928537] Update Tracker - [Reaction:933526] Recruitment of caspase-8 and -10 to FADD complex - v91:[modifyText] [UpdateTracker:9779530] Update Tracker - [Reaction:933526] Recruitment of caspase-8 and -10 to FADD complex - v65:[modifyText]
(hasEvent)	[Pathway:R-HSA-933543] NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
(precedingEvent)	[Reaction:R-HSA-933523] Dimerzation of procaspase-8, procaspase-10