Reactome | viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS

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viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS Show undefined attributes

authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
category	binding
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:168919] de Bono, B, 2005-11-22 18:36:47
dbId	168909
displayName	viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS
edited	[InstanceEdit:918228] Garapati, P V, 2010-08-02
eventOf	[Pathway:R-HSA-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - Homo sapiens
followingEvent	[Reaction:R-HSA-168934] MAVS interacts with RIPK1 and FADD - Homo sapiens [Reaction:R-HSA-990528] Interaction of PCBP2 with MAVS - Homo sapiens [Reaction:R-HSA-918227] Recruitment of TRAF3 to MAVS - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-913730] MAVS [mitochondrial outer membrane] [DefinedSet:R-HSA-918192] viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:177847] IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction [LiteratureReference:918219] Crystal structure of human IPS-1/MAVS/VISA/Cardif caspase activation recruitment domain [LiteratureReference:918176] VISA is an adapter protein required for virus-triggered IFN-beta signaling [LiteratureReference:1227961] Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3
maxDepth	1
modified	[InstanceEdit:9928382] Matthews, Lisa, 2024-11-15
name	viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS RIG-I/MDA5 interacts with IPS-1
orthologousEvent	[Reaction:R-GGA-1227709] Activated MDA5 binds IPS-1 - Gallus gallus
output	[Complex:R-HSA-918201] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane]
precedingEvent	[Reaction:R-HSA-918224] DDX58 is K63 polyubiquitinated - Homo sapiens [Reaction:R-HSA-913725] viral dsRNA binds IFIH1:TKFC - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[NegativeRegulation:R-HSA-992760] Negative regulation by 'MAVS:NLRX1 [mitochondrial outer membrane]' [NegativeRegulation:R-HSA-992762] Negative regulation by 'viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:NLRC5 [cytosol]'
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:5617433] Rotavirus [Species:9013948] Measles virus [Species:9031716] Influenza A virus [Species:9717528] Human respiratory syncytial virus A
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30 [InstanceEdit:9928383] Matthews, Lisa, 2024-11-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-168909
summation	[Summation:177874] Upon binding viral dsRNA, Probable ATP-dependent RNA helicas... [Summation:937331] NLRC5 competes with MAVS (IPS-1) for binding to the CARD dom... [Summation:936543] NLRX1 is a member of nucleotide-binding domain and leucine-r...
updateTrackers	[UpdateTracker:9780905] Update Tracker - [Reaction:168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS - v61:[modifyText] [UpdateTracker:9789676] Update Tracker - [Reaction:168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS - v37:[addLiteratureReference] [UpdateTracker:9775532] Update Tracker - [Reaction:168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS - v78:[addSummation] [UpdateTracker:9928436] Update Tracker - [Reaction:168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS - v91:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9780905] Update Tracker - [Reaction:168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS - v61:[modifyText] [UpdateTracker:9789676] Update Tracker - [Reaction:168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS - v37:[addLiteratureReference] [UpdateTracker:9775532] Update Tracker - [Reaction:168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS - v78:[addSummation] [UpdateTracker:9928436] Update Tracker - [Reaction:168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS - v91:[modifyText]
(hasEvent)	[Pathway:R-HSA-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta
(precedingEvent)	[Reaction:R-HSA-168934] MAVS interacts with RIPK1 and FADD [Reaction:R-HSA-990528] Interaction of PCBP2 with MAVS [Reaction:R-HSA-918227] Recruitment of TRAF3 to MAVS

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