Reactome | p-S172-TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane]

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p-S172-TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane] Show undefined attributes

compartment	[Compartment:74700] endosome membrane
created	[InstanceEdit:9828202] Shamovsky, Veronica, 2023-02-10
dbId	9828208
displayName	p-S172-TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane]
hasComponent	[Complex:R-HSA-9013976] K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] [Complex:R-HSA-9730457] p-S172-TBK1:p-S172-TBK1 [cytosol]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:171907] endosome lumen
isChimeric	false
literatureReference	[LiteratureReference:918164] Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response [LiteratureReference:2423829] Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling [LiteratureReference:933507] SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways
maxDepth	7
name	p-S172-TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-S172-TBK1
producedByEvent	[Reaction:R-HSA-9828205] TBK1 is phosphorylated within the activated TLR3 complex - Homo sapiens
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9828208

Referrals

(output)

[Reaction:R-HSA-9828205] TBK1 is phosphorylated within the activated TLR3 complex

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