Reactome | viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane]

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viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] Show undefined attributes

compartment	[Compartment:17906] mitochondrial outer membrane
componentOf	[Complex:R-HSA-918291] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] - Homo sapiens [Complex:R-HSA-983462] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2 [mitochondrial outer membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-918230] Recruitment of TRAF6/TRAF2 to MAVS - Homo sapiens [Reaction:R-HSA-990528] Interaction of PCBP2 with MAVS - Homo sapiens [Reaction:R-HSA-918227] Recruitment of TRAF3 to MAVS - Homo sapiens [Reaction:R-HSA-168934] MAVS interacts with RIPK1 and FADD - Homo sapiens
created	[InstanceEdit:918198] Garapati, P V, 2010-08-02
dbId	918201
displayName	viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane]
hasComponent	[EntityWithAccessionedSequence:R-HSA-913730] MAVS [mitochondrial outer membrane] [DefinedSet:R-HSA-918192] viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol]
inDisease	false
includedLocation	[Compartment:70101] cytosol
isChimeric	false
maxDepth	5
modified	[InstanceEdit:9835855] Shamovsky, Veronica, 2023-05-18
name	viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS
producedByEvent	[BlackBoxEvent:R-HSA-936475] Negative regulation of DDX58/IFIH1 signaling by RNF216 - Homo sapiens [Reaction:R-HSA-168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS - Homo sapiens
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:5617433] Rotavirus [Species:9013948] Measles virus [Species:9031716] Influenza A virus [Species:9717528] Human respiratory syncytial virus A
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-918201
updateTrackers	[UpdateTracker:9898617] Update Tracker - [Complex:918201] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] - v64:[updateContainedComponent] [UpdateTracker:9876968] Update Tracker - [Complex:918201] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] - v44:[updateContainedComponent] [UpdateTracker:9897419] Update Tracker - [Complex:918201] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] - v62:[updateContainedComponent] [UpdateTracker:9897262] Update Tracker - [Complex:918201] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] - v61:[modifyName, updateContainedComponent] [UpdateTracker:9892725] Update Tracker - [Complex:918201] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] - v54:[updateContainedComponent] [UpdateTracker:9902307] Update Tracker - [Complex:918201] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] - v77:[updateContainedComponent] [UpdateTracker:9905721] Update Tracker - [Complex:918201] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] - v85:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9898617] Update Tracker - [Complex:918201] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] - v64:[updateContainedComponent] [UpdateTracker:9876968] Update Tracker - [Complex:918201] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] - v44:[updateContainedComponent] [UpdateTracker:9897419] Update Tracker - [Complex:918201] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] - v62:[updateContainedComponent] [UpdateTracker:9897262] Update Tracker - [Complex:918201] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] - v61:[modifyName, updateContainedComponent] [UpdateTracker:9892725] Update Tracker - [Complex:918201] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] - v54:[updateContainedComponent] [UpdateTracker:9902307] Update Tracker - [Complex:918201] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] - v77:[updateContainedComponent] [UpdateTracker:9905721] Update Tracker - [Complex:918201] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] - v85:[updateContainedComponent]
(input)	[Reaction:R-HSA-168934] MAVS interacts with RIPK1 and FADD [Reaction:R-HSA-918230] Recruitment of TRAF6/TRAF2 to MAVS [Reaction:R-HSA-990528] Interaction of PCBP2 with MAVS [Reaction:R-HSA-918227] Recruitment of TRAF3 to MAVS
(hasComponent)	[Complex:R-HSA-918291] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] [Complex:R-HSA-936558] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:TRAF3 [mitochondrial outer membrane] [Complex:R-HSA-983462] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2 [mitochondrial outer membrane] [Complex:R-HSA-918200] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane]
(output)	[BlackBoxEvent:R-HSA-936475] Negative regulation of DDX58/IFIH1 signaling by RNF216 [Reaction:R-HSA-168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS

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