Reactome | TBK1 binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3

Schema > Reaction > Entries

TBK1 binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 Show undefined attributes

authored	[InstanceEdit:9828202] Shamovsky, Veronica, 2023-02-10
category	binding
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:9828202] Shamovsky, Veronica, 2023-02-10
dbId	9828196
deleted	[Deleted:9863259] Deletion of instance: 9013986
displayName	TBK1 binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3
edited	[InstanceEdit:9863258] Shamovsky, Veronica, 2024-02-28
eventOf	[Pathway:R-HSA-9013973] TICAM1-dependent activation of IRF3/IRF7 - Homo sapiens
followingEvent	[Reaction:R-HSA-9828205] TBK1 is phosphorylated within the activated TLR3 complex - Homo sapiens [BlackBoxEvent:R-HSA-9828200] TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 - Homo sapiens [Reaction:R-HSA-9828209] OPTN binds TBK1 within the activated TLR3 complex - Homo sapiens
input	[Complex:R-HSA-9013976] K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] 2 × [EntityWithAccessionedSequence:R-HSA-166267] TBK1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:165917] The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection [LiteratureReference:166859] IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway [LiteratureReference:202505] Regulation and function of IKK and IKK-related kinases [LiteratureReference:5362581] Crystal structure and mechanism of activation of TANK-binding kinase 1
maxDepth	1
modified	[InstanceEdit:9863519] Shamovsky, Veronica, 2024-03-01
name	TBK1 binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3
orthologousEvent	[Reaction:R-GGA-434030] TBK1 is recruited to the Viral dsRNA:TLR3:TICAM1 complex - Gallus gallus
output	[Complex:R-HSA-9828199] TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9013990] TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA - Homo sapiens
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9863280] Muniti?, Ivana, Franjki?, Toni, 2024-02-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9828196
summation	[Summation:9828212] Upon stimulation by pathogen-associated inflammatory signals...

Referrals

(replacementInstances)	[Deleted:9863259] Deletion of instance: 9013986
(precedingEvent)	[Reaction:R-HSA-9828205] TBK1 is phosphorylated within the activated TLR3 complex [BlackBoxEvent:R-HSA-9828200] TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [Reaction:R-HSA-9828209] OPTN binds TBK1 within the activated TLR3 complex
(hasEvent)	[Pathway:R-HSA-9013973] TICAM1-dependent activation of IRF3/IRF7