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GPC1 [plasma membrane]
Stable Identifier
R-HSA-425952
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Glypican-1, Secreted glypican-1, GPC1_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Glypican-1 (GPC1) binds SLIT2 (Homo sapiens)
GPC1:HSPG [plasma membrane] (Homo sapiens)
GPC1 [plasma membrane] (Homo sapiens)
SLIT2,SLIT2 cleavage fragments:GPC1:HSPG [plasma membrane] (Homo sapiens)
GPC1:HSPG [plasma membrane] (Homo sapiens)
GPC1 [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
PSGs bind proteoglycans and TGF-beta1 (Homo sapiens)
PSGs:Proteoglycan,TGFB1 [plasma membrane] (Homo sapiens)
Proteoglycans,TGFB1 [plasma membrane] (Homo sapiens)
GPC1 [plasma membrane] (Homo sapiens)
Proteoglycans,TGFB1 [plasma membrane] (Homo sapiens)
GPC1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35052 GPC1
Gene Names
GPC1
Chain
signal peptide:1-23, chain:24-530, chain:24-, propeptide:531-558
Reference Genes
BioGPS Gene:2817 GPC1
COSMIC (genes):GPC1 GPC1
CTD Gene:2817 GPC1
dbSNP Gene:2817 GPC1
ENSEMBL:ENSG00000063660 GPC1
ENSEMBL:ENSG00000063660.9 GPC1
HGNC:4449 GPC1
KEGG Gene (Homo sapiens):2817 GPC1
Monarch:2817 GPC1
NCBI Gene:2817 GPC1
OMIM:600395 GPC1
UCSC:P35052 GPC1
Reference Transcript
RefSeq:NM_002081.2 GPC1
Other Identifiers
11717361_a_at
11717362_x_at
16893169
202755_PM_s_at
202755_s_at
202756_PM_s_at
202756_s_at
2535769
2535770
2535771
2535772
2535788
2535790
2535791
2535792
2535793
2535795
2535796
2535798
2535799
2535800
2535802
2535804
2535805
2535806
2535807
2535808
2817
33929_at
8049670
A_23_P209904
GE59792
GO:0005507
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005764
GO:0005768
GO:0005773
GO:0005794
GO:0005796
GO:0005829
GO:0005886
GO:0009966
GO:0009986
GO:0014037
GO:0016020
GO:0016477
GO:0017134
GO:0023052
GO:0030154
GO:0030163
GO:0030200
GO:0030312
GO:0031012
GO:0031410
GO:0032288
GO:0040037
GO:0043202
GO:0043226
GO:0043236
GO:0045121
GO:0045202
GO:0048856
GO:0048870
GO:0062023
GO:0070062
GO:1901135
GO:1905475
GO:2001016
HMNXSV003038905
Hs.2699.0.S1_3p_a_at
ILMN_1801516
PH_hs_0023823
TC02001464.hg
X54232_at
g4504080_3p_a_at
Participates
as a component of
GPC1:HSPG [plasma membrane] (Homo sapiens)
as a member of
Proteoglycans,TGFB1 [plasma membrane] (Homo sapiens)
Other forms of this molecule
GPC1 [lysosomal lumen]
HS(6)-GPC1 [lysosomal lumen]
HS(2)-GPC1 [Golgi lumen]
HS(3)-GPC1 [Golgi lumen]
HS(4)-GPC1 [Golgi lumen]
HS(6)-GPC1 [Golgi lumen]
HS(5)-GPC1 [Golgi lumen]
HS(1)-GPC1 [Golgi lumen]
Heparan(4)-GPC1 [Golgi lumen]
Heparan(3)-GPC1 [Golgi lumen]
Heparan(2)-GPC1 [Golgi lumen]
Heparan(1)-GPC1 [Golgi lumen]
Heparan-GPC1 [Golgi lumen]
GlcA-Gal-Gal-Xyl-GPC1 [Golgi lumen]
HS(4)-GPC1 [plasma membrane]
HS(6)-GPC1 [plasma membrane]
HS(2)-GPC1 [plasma membrane]
HS(1)-GPC1 [plasma membrane]
HS(3)-GPC1 [plasma membrane]
HS(5)-GPC1 [plasma membrane]
GPC1 [Golgi lumen]
XylS-GPC1 [Golgi lumen]
Gal-Xyl-GPC1 [Golgi lumen]
Gal-Gal-Xyl-GPC1 [Golgi lumen]
Inferred To
GPC1 [plasma membrane]
(Bos taurus)
GPC1 [plasma membrane]
(Canis familiaris)
GPC1 [plasma membrane]
(Gallus gallus)
GPC1 [plasma membrane]
(Sus scrofa)
gpc1 [plasma membrane]
(Danio rerio)
gpc1 [plasma membrane]
(Xenopus tropicalis)
Gpc1 [plasma membrane]
(Mus musculus)
Gpc1 [plasma membrane]
(Rattus norvegicus)
lon-2 [plasma membrane]
(Caenorhabditis elegans)
dlp [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_002072.2
OpenTargets
ENSG00000063660
HPA
ENSG00000063660-GPC1
GeneCards
P35052
Ensembl
ENSP00000264039
,
ENST00000264039
,
ENSG00000063660
PRO
P35052
Pharos - Targets
P35052
Orphanet
22145
PDB
4BWE
,
4AD7
,
4ACR
,
4YWT
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15530 PDPK1
2
PDPK1 [cytosol]
(R-HSA-202210)
PDPK1 [plasma membrane]
(R-HSA-61459)
0.527
2
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