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GPC1 [plasma membrane]
Stable Identifier
R-HSA-425952
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Glypican-1, Secreted glypican-1, GPC1_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Glypican-1 (GPC1) binds SLIT2 (Homo sapiens)
GPC1:HSPG [plasma membrane] (Homo sapiens)
GPC1 [plasma membrane] (Homo sapiens)
SLIT2,SLIT2 cleavage fragments:GPC1:HSPG [plasma membrane] (Homo sapiens)
GPC1:HSPG [plasma membrane] (Homo sapiens)
GPC1 [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
PSGs bind proteoglycans and TGF-beta1 (Homo sapiens)
PSGs:Proteoglycan,TGFB1 [plasma membrane] (Homo sapiens)
Proteoglycans,TGFB1 [plasma membrane] (Homo sapiens)
GPC1 [plasma membrane] (Homo sapiens)
Proteoglycans,TGFB1 [plasma membrane] (Homo sapiens)
GPC1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35052 GPC1
Gene Names
GPC1
Chain
signal peptide:1-23, chain:24-530, chain:24-, propeptide:531-558
Reference Genes
BioGPS Gene:2817 GPC1
COSMIC (genes):GPC1 GPC1
CTD Gene:2817 GPC1
dbSNP Gene:2817 GPC1
ENSEMBL:ENSG00000063660 GPC1
HGNC:4449 GPC1
KEGG:hsa:2817 GPC1
Monarch:2817 GPC1
NCBI Gene:2817 GPC1
OMIM:600395 GPC1
UCSC:P35052 GPC1
Reference Transcript
RefSeq:NM_002081.2 GPC1
Other Identifiers
11717361_a_at
11717362_x_at
16893169
202755_PM_s_at
202755_s_at
202756_PM_s_at
202756_s_at
2535769
2535770
2535771
2535772
2535775
2535779
2535781
2535784
2535785
2535786
2535787
2535788
2535790
2535791
2535792
2535793
2535794
2535795
2535796
2535797
2535798
2535799
2535800
2535801
2535802
2535803
2535804
2535805
2535806
2535807
2535808
2817
33929_at
8049670
A_23_P209904
GE59792
GO:0005507
GO:0005515
GO:0005576
GO:0005615
GO:0005654
GO:0005768
GO:0005794
GO:0005796
GO:0005829
GO:0005886
GO:0006790
GO:0009966
GO:0009986
GO:0014037
GO:0016477
GO:0017134
GO:0030154
GO:0030163
GO:0030200
GO:0030312
GO:0031012
GO:0031410
GO:0032288
GO:0040037
GO:0043202
GO:0043226
GO:0043236
GO:0045121
GO:0045202
GO:0048870
GO:0062023
GO:0070062
GO:0098552
GO:1901135
GO:1905475
GO:2001016
HMNXSV003038905
Hs.2699.0.S1_3p_a_at
ILMN_1801516
PH_hs_0023823
TC02001464.hg
X54232_at
g4504080_3p_a_at
Participates
as a member of
Proteoglycans,TGFB1 [plasma membrane] (Homo sapiens)
as a component of
GPC1:HSPG [plasma membrane] (Homo sapiens)
Other forms of this molecule
HS(4)-GPC1 [plasma membrane]
HS(6)-GPC1 [plasma membrane]
HS(2)-GPC1 [plasma membrane]
HS(1)-GPC1 [plasma membrane]
HS(3)-GPC1 [plasma membrane]
HS(5)-GPC1 [plasma membrane]
XylS-GPC1 [Golgi lumen]
Gal-Xyl-GPC1 [Golgi lumen]
GPC1 [Golgi lumen]
Gal-Gal-Xyl-GPC1 [Golgi lumen]
GlcA-Gal-Gal-Xyl-GPC1 [Golgi lumen]
HS(3)-GPC1 [Golgi lumen]
HS(4)-GPC1 [Golgi lumen]
HS(2)-GPC1 [Golgi lumen]
HS(1)-GPC1 [Golgi lumen]
Heparan(4)-GPC1 [Golgi lumen]
Heparan(3)-GPC1 [Golgi lumen]
Heparan(2)-GPC1 [Golgi lumen]
Heparan(1)-GPC1 [Golgi lumen]
Heparan-GPC1 [Golgi lumen]
HS(5)-GPC1 [Golgi lumen]
HS(6)-GPC1 [Golgi lumen]
HS(6)-GPC1 [lysosomal lumen]
GPC1 [lysosomal lumen]
Inferred To
GPC1 [plasma membrane]
(Bos taurus)
GPC1 [plasma membrane]
(Caenorhabditis elegans)
GPC1 [plasma membrane]
(Canis familiaris)
GPC1 [plasma membrane]
(Gallus gallus)
GPC1 [plasma membrane]
(Sus scrofa)
gpc1 [plasma membrane]
(Danio rerio)
gpc1 [plasma membrane]
(Xenopus tropicalis)
Homologues of GPC1 [plasma membrane]
(Caenorhabditis elegans)
Gpc1 [plasma membrane]
(Mus musculus)
Gpc1 [plasma membrane]
(Rattus norvegicus)
lon-2 [plasma membrane]
(Caenorhabditis elegans)
gpn-1 [plasma membrane]
(Caenorhabditis elegans)
dlp [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_002072.2
OpenTargets
ENSG00000063660
ENSEMBL
ENST00000264039
,
ENSP00000264039
HPA
ENSG00000063660-GPC1
PRO
P35052
Pharos - Targets
P35052
GlyGen
P35052
PDB
4BWE
,
4ACR
,
4AD7
,
4YWT
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9HB96 FANCE
2
FANCE [cytosol]
(R-HSA-420786)
FANCE [nucleoplasm]
(R-HSA-419543)
0.527
2
UniProt:O15530 PDPK1
3
p-S241-PDPK1 [cytosol]
(R-HSA-9860799)
PDPK1 [cytosol]
(R-HSA-202210)
PDPK1 [plasma membrane]
(R-HSA-61459)
0.527
2
UniProt:P32249 GPR183
1
GPR183 [plasma membrane]
(R-HSA-8851676)
0.527
4
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