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SETD1B [nucleoplasm]
Stable Identifier
R-HSA-5244714
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Histone-lysine N-methyltransferase SETD1B ecNumber2.1.1.43/ecNumber, SET1B_HUMAN, KMT2G
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
PKMTs methylate histone lysines (Homo sapiens)
Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Homo sapiens)
Core MLL complex, SMYD3, PRDM9 [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Homo sapiens)
SETD3, SETD7, WHSC1L1, Core MLL complex [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Homo sapiens)
SUV39H1, SUV39H2, SETDB1, SETDB2 [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Homo sapiens)
WHSC1L1, Core MLL complex, SMYD3, SETD3 [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Homo sapiens)
H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the GP1BA gene (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the ITGA2B gene (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the MIR27A gene (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the THBS1 gene (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
SETD1B [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UPS6 SETD1B
Gene Names
SETD1B, KIAA1076, KMT2G, SET1B
Chain
chain:1-1966
Reference Genes
BioGPS Gene:23067 SETD1B
COSMIC (genes):SETD1B SETD1B
CTD Gene:23067 SETD1B
dbSNP Gene:23067 SETD1B
ENSEMBL:ENSG00000139718.12 SETD1B
HGNC:29187 SETD1B
Monarch:23067 SETD1B
NCBI Gene:23067 SETD1B
OMIM:611055 SETD1B
UCSC:Q9UPS6 SETD1B
Reference Transcript
RefSeq:XM_005253858.4 SETD1B
RefSeq:XM_006719296.3 SETD1B
RefSeq:NM_015048.1 SETD1B
Other Identifiers
0001660438
11742418_a_at
16758163
213153_PM_at
213153_at
23067
3434988
3434989
3434990
3434991
3434992
3434993
3434994
3434995
3434996
3434997
3434998
3435003
3435004
3435005
3435007
3435009
3435010
3435011
3435012
3435013
3435016
3435017
3435018
3435019
3435021
3435022
3435023
3435024
3435025
3435026
3435027
3435028
3435032
3435033
3435034
3435035
3435036
3435037
3435038
3435039
38173_at
7959314
A_19_P00809382
A_23_P319895
GE53731
GE538510
GO:0003676
GO:0003723
GO:0005515
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0006325
GO:0008168
GO:0016607
GO:0016740
GO:0018024
GO:0032259
GO:0032991
GO:0035097
GO:0036211
GO:0042800
GO:0043226
GO:0044648
GO:0048188
GO:0051568
GO:0080182
GO:0097692
GO:0140096
HMNXSV003041149
Hs.154525.0.S1_3p_at
ILMN_1813573
PH_hs_0009302
TC12000963.hg
Participates
as a member of
SUV39H1, SUV39H2, SETDB1, SETDB2 [nucleoplasm] (Homo sapiens)
as a candidate of
KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] (Homo sapiens)
Inferred To
Setd1b [nucleoplasm]
(Mus musculus)
Setd1b [nucleoplasm]
(Rattus norvegicus)
SETD1B [nucleoplasm]
(Bos taurus)
SETD1B [nucleoplasm]
(Canis familiaris)
setd1ba [nucleoplasm]
(Danio rerio)
setd1b [nucleoplasm]
(Xenopus tropicalis)
SETD1A [nucleoplasm]
(Gallus gallus)
Set1 [nucleoplasm]
(Drosophila melanogaster)
set-2 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
XP_005253915.1
,
XP_006719359.1
,
NP_055863.1
Guide to Pharmacology - Targets
2701
OpenTargets
ENSG00000139718
GeneCards
Q9UPS6
HPA
ENSG00000139718-SETD1B
Ensembl
ENSG00000139718
,
ENSP00000442924
,
ENST00000542440
,
ENSP00000474253
,
ENST00000604567
,
ENSP00000481531
,
ENST00000619791
PRO
Q9UPS6
Pharos - Targets
Q9UPS6
Orphanet
29799
HMDB Protein
HMDBP09034
PDB
3UVO
,
4ES0
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.725
4
UniProt:Q9UBL3 ASH2L
1
ASH2L [nucleoplasm]
(R-HSA-1629834)
0.527
2
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