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Heparan(2)-GPC1 [Golgi lumen]
Stable Identifier
R-HSA-2076501
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
GPC1, Glypican-1, Secreted glypican-1, GPC1_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with glycosaminoglycan metabolism (Homo sapiens)
Defective EXT1 causes exostoses 1, TRPS2 and CHDS (Homo sapiens)
Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)
Heparan(2)-PGs [Golgi lumen] (Homo sapiens)
Heparan(2)-GPC1 [Golgi lumen] (Homo sapiens)
Defective EXT2 causes exostoses 2 (Homo sapiens)
Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)
Heparan(2)-PGs [Golgi lumen] (Homo sapiens)
Heparan(2)-GPC1 [Golgi lumen] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG biosynthesis (Homo sapiens)
EXT1:EXT2 transfer GlcNAc to the heparan chain (Homo sapiens)
Heparan(2)-PGs [Golgi lumen] (Homo sapiens)
Heparan(2)-GPC1 [Golgi lumen] (Homo sapiens)
EXT1:EXT2 transfers GlcA to heparan (Homo sapiens)
Heparan(2)-PGs [Golgi lumen] (Homo sapiens)
Heparan(2)-GPC1 [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35052 GPC1
Gene Names
GPC1
Chain
signal peptide:1-23, chain:24-530, chain:24-, propeptide:531-558
Reference Genes
BioGPS Gene:2817 GPC1
COSMIC (genes):GPC1 GPC1
CTD Gene:2817 GPC1
dbSNP Gene:2817 GPC1
ENSEMBL:ENSG00000063660 GPC1
ENSEMBL_homo_sapiens_GENE:ENSG00000063660.9 GPC1
HGNC:4449 GPC1
KEGG Gene (Homo sapiens):2817 GPC1
Monarch:2817 GPC1
NCBI Gene:2817 GPC1
OMIM:600395 GPC1
UCSC:P35052 GPC1
Reference Transcript
RefSeq:NM_002081.2 GPC1
Other Identifiers
11717361_a_at
11717362_x_at
16893169
202755_PM_s_at
202755_s_at
202756_PM_s_at
202756_s_at
2535769
2535770
2535771
2535772
2535788
2535790
2535791
2535792
2535793
2535795
2535796
2535798
2535799
2535800
2535802
2535804
2535805
2535806
2535807
2535808
2817
33929_at
8049670
A_23_P209904
GE59792
GO:0005507
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005764
GO:0005768
GO:0005773
GO:0005794
GO:0005796
GO:0005829
GO:0005886
GO:0006790
GO:0009966
GO:0009986
GO:0014037
GO:0016020
GO:0016477
GO:0017134
GO:0023052
GO:0030154
GO:0030163
GO:0030200
GO:0030312
GO:0031012
GO:0031410
GO:0032288
GO:0040037
GO:0043202
GO:0043226
GO:0043236
GO:0045121
GO:0045202
GO:0048856
GO:0048870
GO:0062023
GO:0070062
GO:0098552
GO:1901135
GO:1905475
GO:2001016
HMNXSV003038905
Hs.2699.0.S1_3p_a_at
ILMN_1801516
PH_hs_0023823
TC02001464.hg
X54232_at
g4504080_3p_a_at
Participates
as a member of
Heparan(2)-PGs [Golgi lumen] (Homo sapiens)
Other forms of this molecule
GPC1 [lysosomal lumen]
HS(6)-GPC1 [lysosomal lumen]
HS(6)-GPC1 [Golgi lumen]
HS(5)-GPC1 [Golgi lumen]
Heparan-GPC1 [Golgi lumen]
Heparan(1)-GPC1 [Golgi lumen]
Heparan(3)-GPC1 [Golgi lumen]
Heparan(4)-GPC1 [Golgi lumen]
HS(1)-GPC1 [Golgi lumen]
HS(2)-GPC1 [Golgi lumen]
HS(4)-GPC1 [Golgi lumen]
HS(3)-GPC1 [Golgi lumen]
GlcA-Gal-Gal-Xyl-GPC1 [Golgi lumen]
HS(4)-GPC1 [plasma membrane]
HS(6)-GPC1 [plasma membrane]
HS(2)-GPC1 [plasma membrane]
HS(1)-GPC1 [plasma membrane]
HS(3)-GPC1 [plasma membrane]
HS(5)-GPC1 [plasma membrane]
GPC1 [plasma membrane]
XylS-GPC1 [Golgi lumen]
Gal-Xyl-GPC1 [Golgi lumen]
GPC1 [Golgi lumen]
Gal-Gal-Xyl-GPC1 [Golgi lumen]
Inferred To
gpc1 [Golgi lumen]
(Danio rerio)
gpc1 [Golgi lumen]
(Xenopus tropicalis)
GPC1 [Golgi lumen]
(Bos taurus)
GPC1 [Golgi lumen]
(Canis familiaris)
GPC1 [Golgi lumen]
(Gallus gallus)
GPC1 [Golgi lumen]
(Sus scrofa)
Homologues of Heparan(2)-GPC1 [Golgi lumen]
(Caenorhabditis elegans)
dlp [Golgi lumen]
(Drosophila melanogaster)
lon-2 [Golgi lumen]
(Caenorhabditis elegans)
Gpc1 [Golgi lumen]
(Mus musculus)
Gpc1 [Golgi lumen]
(Rattus norvegicus)
gpn-1 [Golgi lumen]
(Caenorhabditis elegans)
Heparan(2)-GPC1 [Golgi lumen]
(Caenorhabditis elegans)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63648) at unknown position
Modification
alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_002072.2
OpenTargets
ENSG00000063660
GeneCards
P35052
HPA
ENSG00000063660-GPC1
Ensembl
ENSP00000264039
,
ENSG00000063660
,
ENST00000264039
PRO
P35052
Pharos - Targets
P35052
Orphanet
22145
PDB
4ACR
,
4BWE
,
4YWT
,
4AD7
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P32249 GPR183
1
GPR183 [plasma membrane]
(R-HSA-8851676)
0.527
4
UniProt:Q9HB96 FANCE
2
FANCE [cytosol]
(R-HSA-420786)
FANCE [nucleoplasm]
(R-HSA-419543)
0.527
2
UniProt:O15530 PDPK1
2
PDPK1 [cytosol]
(R-HSA-202210)
PDPK1 [plasma membrane]
(R-HSA-61459)
0.527
2
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