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HS(1)-GPC1 [plasma membrane]
Stable Identifier
R-HSA-2076645
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
GPC1, Glypican-1, Secreted glypican-1, GPC1_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
RSV-host interactions (Homo sapiens)
G protein binds CX3CR1 on host cell surface (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
sG binds to HSPGs (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
HSPGs:sG [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
Respiratory syncytial virus (RSV) attachment and entry (Homo sapiens)
G protein binds CX3CR1 on host cell surface (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
Attachment and Entry (Homo sapiens)
Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
Endocytosis of SARS-CoV-2 Virion (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG biosynthesis (Homo sapiens)
Some HSPGs are secreted to the plasma membrane (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
CR:atREs binds apoE and HSPG (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
CR:atREs binds apoE and HSPG (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-GPC1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35052 GPC1
Gene Names
GPC1
Chain
signal peptide:1-23, chain:24-530, chain:24-, propeptide:531-558
Reference Genes
BioGPS Gene:2817 GPC1
COSMIC (genes):GPC1 GPC1
CTD Gene:2817 GPC1
dbSNP Gene:2817 GPC1
ENSEMBL:ENSG00000063660 GPC1
ENSEMBL_homo_sapiens_GENE:ENSG00000063660.9 GPC1
HGNC:4449 GPC1
KEGG Gene (Homo sapiens):2817 GPC1
Monarch:2817 GPC1
NCBI Gene:2817 GPC1
OMIM:600395 GPC1
UCSC:P35052 GPC1
Reference Transcript
RefSeq:NM_002081.2 GPC1
Other Identifiers
11717361_a_at
11717362_x_at
16893169
202755_PM_s_at
202755_s_at
202756_PM_s_at
202756_s_at
2535769
2535770
2535771
2535772
2535788
2535790
2535791
2535792
2535793
2535795
2535796
2535798
2535799
2535800
2535802
2535804
2535805
2535806
2535807
2535808
2817
33929_at
8049670
A_23_P209904
GE59792
GO:0005507
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005764
GO:0005768
GO:0005773
GO:0005794
GO:0005796
GO:0005829
GO:0005886
GO:0006790
GO:0009966
GO:0009986
GO:0014037
GO:0016020
GO:0016477
GO:0017134
GO:0023052
GO:0030154
GO:0030163
GO:0030200
GO:0030312
GO:0031012
GO:0031410
GO:0032288
GO:0040037
GO:0043202
GO:0043226
GO:0043236
GO:0045121
GO:0045202
GO:0048856
GO:0048870
GO:0062023
GO:0070062
GO:0098552
GO:1901135
GO:1905475
GO:2001016
HMNXSV003038905
Hs.2699.0.S1_3p_a_at
ILMN_1801516
PH_hs_0023823
TC02001464.hg
X54232_at
g4504080_3p_a_at
Participates
as a member of
HS(1)-PGs [plasma membrane] (Homo sapiens)
Other forms of this molecule
GPC1 [lysosomal lumen]
HS(6)-GPC1 [lysosomal lumen]
HS(1)-GPC1 [Golgi lumen]
HS(2)-GPC1 [Golgi lumen]
HS(3)-GPC1 [Golgi lumen]
HS(4)-GPC1 [Golgi lumen]
HS(6)-GPC1 [Golgi lumen]
HS(5)-GPC1 [Golgi lumen]
Heparan-GPC1 [Golgi lumen]
Heparan(1)-GPC1 [Golgi lumen]
Heparan(2)-GPC1 [Golgi lumen]
Heparan(4)-GPC1 [Golgi lumen]
Heparan(3)-GPC1 [Golgi lumen]
GPC1 [Golgi lumen]
HS(4)-GPC1 [plasma membrane]
HS(6)-GPC1 [plasma membrane]
HS(2)-GPC1 [plasma membrane]
HS(3)-GPC1 [plasma membrane]
HS(5)-GPC1 [plasma membrane]
GPC1 [plasma membrane]
Gal-Gal-Xyl-GPC1 [Golgi lumen]
GlcA-Gal-Gal-Xyl-GPC1 [Golgi lumen]
Gal-Xyl-GPC1 [Golgi lumen]
XylS-GPC1 [Golgi lumen]
Inferred To
GPC1 [plasma membrane]
(Bos taurus)
GPC1 [plasma membrane]
(Canis familiaris)
GPC1 [plasma membrane]
(Gallus gallus)
GPC1 [plasma membrane]
(Sus scrofa)
gpc1 [plasma membrane]
(Danio rerio)
gpc1 [plasma membrane]
(Xenopus tropicalis)
Homologues of HS(1)-GPC1 [plasma membrane]
(Caenorhabditis elegans)
Gpc1 [plasma membrane]
(Mus musculus)
Gpc1 [plasma membrane]
(Rattus norvegicus)
lon-2 [plasma membrane]
(Caenorhabditis elegans)
HS(1)-GPC1 [plasma membrane]
(Caenorhabditis elegans)
gpn-1 [plasma membrane]
(Caenorhabditis elegans)
dlp [plasma membrane]
(Drosophila melanogaster)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63652) at unknown position
Modification
beta-D-GlcA-(1->4)-alpha-D-GlcNS-(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNS-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_002072.2
OpenTargets
ENSG00000063660
HPA
ENSG00000063660-GPC1
GeneCards
P35052
Ensembl
ENST00000264039
,
ENSG00000063660
,
ENSP00000264039
PRO
P35052
Pharos - Targets
P35052
PDB
4ACR
,
4BWE
,
4AD7
,
4YWT
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15530 PDPK1
3
p-S241-PDPK1 [cytosol]
(R-HSA-9860799)
PDPK1 [cytosol]
(R-HSA-202210)
PDPK1 [plasma membrane]
(R-HSA-61459)
0.527
2
UniProt:Q9HB96 FANCE
2
FANCE [cytosol]
(R-HSA-420786)
FANCE [nucleoplasm]
(R-HSA-419543)
0.527
2
UniProt:P32249 GPR183
1
GPR183 [plasma membrane]
(R-HSA-8851676)
0.527
4
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