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KRR1 [nucleoplasm]
Stable Identifier
R-HSA-6790611
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
KRR1 small subunit processome component homolog, KRR1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Homo sapiens)
18SE pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
KRR1 [nucleoplasm] (Homo sapiens)
21S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
KRR1 [nucleoplasm] (Homo sapiens)
30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)
21S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
KRR1 [nucleoplasm] (Homo sapiens)
30S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
KRR1 [nucleoplasm] (Homo sapiens)
45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA (Homo sapiens)
30S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
KRR1 [nucleoplasm] (Homo sapiens)
45S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
KRR1 [nucleoplasm] (Homo sapiens)
47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA (Homo sapiens)
45S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
KRR1 [nucleoplasm] (Homo sapiens)
47S pre-rRNA:SSU processome [nucleoplasm] (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
KRR1 [nucleoplasm] (Homo sapiens)
rRNA modification in the nucleus and cytosol (Homo sapiens)
EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248 (Homo sapiens)
SSU Processome [nucleoplasm] (Homo sapiens)
KRR1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13601 KRR1
Gene Names
KRR1, HRB2
Chain
initiator methionine:, chain:2-381
Reference Genes
BioGPS Gene:11103 KRR1
COSMIC (genes):KRR1 KRR1
CTD Gene:11103 KRR1
dbSNP Gene:11103 KRR1
ENSEMBL:ENSG00000111615 KRR1
HGNC:5176 KRR1
Monarch:11103 KRR1
NCBI Gene:11103 KRR1
OMIM:612817 KRR1
UCSC:Q13601 KRR1
Reference Transcript
RefSeq:NM_007043.6 KRR1
Other Identifiers
11103
11728682_at
11728683_x_at
11728684_at
11749630_a_at
11753350_x_at
16767714
16767717
203202_PM_at
203202_at
203203_PM_s_at
203203_s_at
233515_3p_at
233515_PM_at
233515_at
239668_PM_at
239668_at
243930_PM_x_at
243930_x_at
3462686
3462688
3462689
3462690
3462692
3462694
3462695
3462696
3462697
3462698
3462699
3462700
3462701
3462702
3462703
3462704
3462705
3462706
3462710
3462711
3462712
3462714
3462715
3462716
3462717
3462718
3462719
3462720
3462721
3462722
3462723
3462724
3462727
3462728
3462729
40250_at
44354_at
57609_at
67222_at
78418_at
7965022
84181_at
A_23_P2216
A_32_P326819
GE81713
GE839301
GE869859
GO:0003676
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0006364
GO:0016020
GO:0032040
GO:0042254
GO:0042274
GO:0043226
GO:0045171
GO:1990904
HMNXSV003011324
HMNXSV003053101
Hs.100911.0.S1_3p_at
Hs.100911.0.S1_3p_x_at
Hs.154762.0.A2_3p_at
Hs.165165.0.A1_3p_at
Hs.165165.0.A1_3p_x_at
Hs.205558.0.A1_3p_at
ILMN_1767579
PH_hs_0029550
PH_hs_0036563
TC12001746.hg
TC12001747.hg
U55766_at
g5902047_3p_a_at
p3297
Participates
as a component of
SSU Processome [nucleoplasm] (Homo sapiens)
Inferred To
krr1 [nucleoplasm]
(Dictyostelium discoideum)
dbe [nucleoplasm]
(Drosophila melanogaster)
mis3 [nucleoplasm]
(Schizosaccharomyces pombe)
Krr1 [nucleoplasm]
(Mus musculus)
LOC475405 [nucleoplasm]
(Canis familiaris)
krr-1 [nucleoplasm]
(Caenorhabditis elegans)
KRR1 [nucleoplasm]
(Bos taurus)
KRR1 [nucleoplasm]
(Gallus gallus)
KRR1 [nucleoplasm]
(Plasmodium falciparum)
KRR1 [nucleoplasm]
(Rattus norvegicus)
KRR1 [nucleoplasm]
(Saccharomyces cerevisiae)
KRR1 [nucleoplasm]
(Sus scrofa)
Cross References
ENSEMBL
ENST00000229214
,
ENSP00000411740
,
ENSP00000229214
,
ENST00000438169
OpenTargets
ENSG00000111615
HPA
ENSG00000111615-KRR1
PRO
Q13601
Pharos - Targets
Q13601
PDB
7MQ8
,
7MQ9
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62263 RPS14
2
RPS14 [cytosol]
(R-HSA-72333)
RPS14 [nucleoplasm]
(R-HSA-6790669)
0.742
6
UniProt:Q8TBF4 ZCRB1
2
ZCRB1 [cytosol]
(R-HSA-9682010)
ZCRB1 [nucleoplasm]
(R-HSA-6787853)
0.527
3
UniProt:P67809 YBX1
5
p-S32,S36-YBX1 [nucleoplasm]
(R-HSA-9733227)
p-S32,S36-YBX1 [cytosol]
(R-HSA-9736837)
YBX1 [cytosol]
(R-HSA-9736840)
YBX1 [nucleoplasm]
(R-HSA-72041)
YBX1 [extracellular region]
(R-HSA-9017791)
0.527
3
UniProt:Q15646 OASL
1
OASL [cytosol]
(R-HSA-1015678)
0.527
2
UniProt:Q9H9Z2 LIN28A
1
LIN28A [cytosol]
(R-HSA-500391)
0.527
3
UniProt:P62277 RPS13
2
RPS13 [cytosol]
(R-HSA-72331)
RPS13 [nucleoplasm]
(R-HSA-6791198)
0.527
3
UniProt:P16104 H2AFX
7
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
0.527
3
UniProt:P15880 RPS2
3
RPS2 [cytosol]
(R-HSA-72347)
Me2aR-RPS2 [cytosol]
(R-HSA-8879138)
RPS2 [nucleoplasm]
(R-HSA-6790655)
0.527
3
UniProt:P62753 RPS6
4
RPS6 [cytosol]
(R-HSA-72381)
p-5S-RPS6 [cytosol]
(R-HSA-165727)
3OHR147-RPS6 [cytosol]
(R-HSA-9629876)
RPS6 [nucleoplasm]
(R-HSA-6790606)
0.483
4
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