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CARD9 [cytosol]
Stable Identifier
R-HSA-561194
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Caspase recruitment domain-containing protein 9, CARD9_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
CARD9 oligomerizes (Homo sapiens)
CARD9 [cytosol] (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
NOD1/2 Signaling Pathway (Homo sapiens)
CARD9 binds RIP2 (and NOD2) (Homo sapiens)
CARD9 [cytosol] (Homo sapiens)
PAMP:NOD oligomer:RIP2:CARD9 [cytosol] (Homo sapiens)
CARD9 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H257 CARD9
Gene Names
CARD9
Chain
chain:1-536
Reference Genes
BioGPS Gene:64170 CARD9
COSMIC (genes):CARD9 CARD9
CTD Gene:64170 CARD9
dbSNP Gene:64170 CARD9
ENSEMBL:ENSG00000187796 CARD9
ENSEMBL_homo_sapiens_GENE:ENSG00000187796.16 CARD9
HGNC:16391 CARD9
KEGG Gene (Homo sapiens):64170 CARD9
Monarch:64170 CARD9
NCBI Gene:64170 CARD9
OMIM:607212 CARD9
UCSC:Q9H257 CARD9
Reference Transcript
RefSeq:NM_052813.4 CARD9
RefSeq:NM_052814.3 CARD9
Other Identifiers
11736526_a_at
17099901
220162_PM_s_at
220162_s_at
3229845
3229846
3229847
3229848
3229849
3229850
3229851
3229852
3229853
3229858
3229860
3229861
3229863
3229864
3229865
3229867
3229869
3229870
3229871
3229873
3229874
3229879
64170
81574_at
8165107
A_23_P500433
A_24_P180830
A_33_P3389573
GE82677
GO:0001819
GO:0002250
GO:0002376
GO:0002446
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006954
GO:0007254
GO:0009410
GO:0009620
GO:0012501
GO:0016064
GO:0023052
GO:0032449
GO:0032494
GO:0032495
GO:0032663
GO:0032675
GO:0032680
GO:0032722
GO:0032725
GO:0032740
GO:0032755
GO:0032760
GO:0032874
GO:0032991
GO:0042802
GO:0042803
GO:0042981
GO:0043123
GO:0043280
GO:0043330
GO:0043621
GO:0045087
GO:0045089
GO:0046330
GO:0046872
GO:0048874
GO:0050700
GO:0050830
GO:0050896
GO:0051092
GO:0051260
GO:0051403
GO:0051607
GO:0060907
GO:0061760
GO:0065003
GO:0070374
GO:0098542
GO:1900017
GO:1904044
GO:2000318
HMNXSV003044985
ILMN_1712532
PH_hs_0035585
TC09002924.hg
g11641262_3p_a_at
Participates
as an input of
CARD9 oligomerizes (Homo sapiens)
CARD9 binds RIP2 (and NOD2) (Homo sapiens)
as a component of
PAMP:NOD oligomer:RIP2:CARD9 [cytosol] (Homo sapiens)
Other forms of this molecule
CARD9 [plasma membrane]
p-T231-CARD9 [plasma membrane]
Inferred To
card9 [cytosol]
(Xenopus tropicalis)
CARD9 [cytosol]
(Bos taurus)
CARD9 [cytosol]
(Canis familiaris)
CARD9 [cytosol]
(Gallus gallus)
CARD9 [cytosol]
(Mus musculus)
CARD9 [cytosol]
(Rattus norvegicus)
CARD9 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_434701.1
,
NP_434700.2
OpenTargets
ENSG00000187796
GeneCards
Q9H257
HPA
ENSG00000187796-CARD9
Ensembl
ENST00000371734
,
ENSG00000187796
,
ENSP00000360797
,
ENSP00000360799
,
ENST00000489932
,
ENST00000371732
,
ENSP00000451368
PRO
Q9H257
Pharos - Targets
Q9H257
Orphanet
18982
PDB
6E26
,
6N2M
,
6E28
,
6N2P
,
6E25
,
6E27
Interactors (63)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q3B820 F161A
0.666
4
UniProt:Q9Y4E8 USP25
1
USP15 [cytosol]
(R-HSA-2173138)
0.666
4
UniProt:Q96GN5 CDA7L
0.666
4
UniProt:Q7Z3I7 ZN572
0.666
7
UniProt:Q08117 TLE5
1
AES [nucleoplasm]
(R-HSA-4648963)
0.666
4
UniProt:P08727 KRT19
1
KRT19 [cytosol]
(R-HSA-6809617)
0.666
4
UniProt:P36406 TRI23
0.666
4
UniProt:Q6NYC8 PPR18
0.666
4
UniProt:Q9P286 PAK5
2
PAK7 [plasma membrane]
(R-HSA-211555)
PAK5 [cytosol]
(R-HSA-428459)
0.666
5
UniProt:Q6NT76 HMBX1
0.556
3
UniProt:Q9H5Z6 F124B
0.556
3
UniProt:Q2TBE0 CWF19L2
1
CWF19L2 [nucleoplasm]
(R-HSA-9770846)
0.556
3
UniProt:Q99598 TSNAX
1
TSNAX [cytosol]
(R-HSA-5216130)
0.556
5
UniProt:Q8TD31-3 CCHCR1
0.556
3
UniProt:Q8NHQ1 CEP70
1
CEP70 [cytosol]
(R-HSA-380257)
0.556
3
UniProt:Q5VWN6-2 TASOR2
0.556
3
UniProt:Q9H2G9 BLZF1
1
BLZF1 [Golgi membrane]
(R-HSA-2422372)
0.556
3
UniProt:Q8IWZ5 TRI42
0.556
3
UniProt:Q8IYA8 IHO1
0.556
3
UniProt:Q9Y247 FA50B
0.556
3
UniProt:Q53TS8 CTSRT
0.556
3
UniProt:Q8N8B7 TEANC
0.556
3
IntAct:EBI-10171679 386682
0.556
3
UniProt:Q14D33 RTP5
0.556
3
UniProt:Q13829 TNFAIP1
1
TNFAIP1 [cytosol]
(R-HSA-9696531)
0.556
3
UniProt:Q96BZ8 LENG1
1
LENG1 [nucleoplasm]
(R-HSA-9769590)
0.556
3
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.556
3
UniProt:P0DTD1-PRO_0000449633 REP
0.556
3
UniProt:A8K932 A8K932
0.556
3
UniProt:Q548N1 Q548N1
0.556
3
UniProt:Q8N3Z6 ZCHC7
0.556
3
UniProt:Q7Z6G3-2 NECAB2
0.556
3
UniProt:O75558 STX11
0.556
3
UniProt:Q6P1W5 CA094
0.556
3
UniProt:Q96PV4 PNMA5
0.556
3
UniProt:Q8IYX8-2 CEP57L1
0.556
3
UniProt:P56279 TCL1A
0.556
3
IntAct:EBI-10173330 386677
0.556
3
UniProt:O14639 ABLIM1
1
ABLIM1 [cytosol]
(R-HSA-416771)
0.556
3
UniProt:O60573 EIF4E2
1
EIF4E2 [cytosol]
(R-HSA-1678822)
0.556
3
UniProt:P40425 PBX2
0.556
3
UniProt:Q96SQ5 ZNF587
1
ZNF587 [nucleoplasm]
(R-HSA-2127565)
0.556
3
UniProt:Q9Y2D8 ADIP
0.556
3
UniProt:Q9Y2J4-4 AMOTL2
0.556
5
UniProt:P63165 SUMO1
11
lysyl-G97-SUMO1 [plasma membrane]
(R-HSA-9762382)
lysyl-G97-SUMO1 [nucleolus]
(R-HSA-9762385)
lysyl-G97-SUMO1 [viral capsid]
(R-HSA-9762386)
UBE2I-G97-SUMO1 [cytosol]
(R-HSA-4656941)
lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9762380)
lysyl-G97-SUMO1 [cytosol]
(R-HSA-9762266)
UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-3730622)
UBA2-G97-SUMO1 [nucleoplasm]
(R-HSA-3730616)
SUMO1 [nucleoplasm]
(R-HSA-877304)
SUMO1(2-101) [nucleoplasm]
(R-HSA-2990831)
lysyl-G97-SUMO1 [nucleoplasm]
(R-HSA-9761562)
0.556
3
UniProt:Q9BYV2 TRI54
0.556
3
UniProt:P60370 KRTAP10-5
1
KRTAP10-5 [cytosol]
(R-HSA-6810260)
0.556
3
UniProt:Q7L273 KCTD9
0.556
3
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.556
3
UniProt:P15622-3 ZNF250
0.556
3
UniProt:P50222 MEOX2
0.556
3
UniProt:Q9BRK4 LZTS2
0.556
3
UniProt:Q9UII6 DS13B
0.556
3
UniProt:Q8N720 ZNF655
1
ZNF655 [nucleoplasm]
(R-HSA-2127575)
0.556
3
UniProt:Q8TAU3 ZNF417
1
ZNF417 [nucleoplasm]
(R-HSA-1247539)
0.556
3
UniProt:Q8IXK0 PHC2
1
PHC2 [nucleoplasm]
(R-HSA-389112)
0.556
3
UniProt:Q14134 TRIM29
1
TRIM29 [cytosol]
(R-HSA-5624343)
0.556
3
UniProt:P25800 LMO1
1
LMO1 [nucleoplasm]
(R-HSA-8956514)
0.556
3
UniProt:Q9UER7 DAXX
13
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX [nucleoplasm]
(R-HSA-3222068)
0.556
3
UniProt:Q9UBB9 TFIP11
1
TFIP11 [nucleoplasm]
(R-HSA-8869310)
0.556
3
UniProt:P55081 MFAP1
1
MFAP1 [nucleoplasm]
(R-HSA-2396419)
0.556
3
UniProt:Q6ZU52 K0408
0.553
2
UniProt:O95999 BCL10
3
K48polyUb-BCL10 [cytosol]
(R-HSA-8939329)
BCL10 [cytosol]
(R-HSA-202447)
p-BCL10 [cytosol]
(R-HSA-202488)
0.547
6
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