PTEN missense mutation that results in the substitution of arginine at position 173 with histidine affects the phosphatase domain of PTEN. Arginine residue R173 is involved in the formation of intedomain hydrogen bonds between the phosphatase domain and the membrane-binding C2 domain (Lee et al. 1999). PTEN R173H (Arg173His) mutant shows markedly decreased phosphoinositide phosphatase activity (Han et al. 2000).
Kato, H, Shibata, H, Matsuno, S, Shiiba, K, Han, SY, Kato, S, Ishioka, C, Ishii, S, Kanamaru, R, Suzuki, T
Georgescu, MM, Pavletich, NP, Shi, Y, Maehama, T, Pandolfi, P, Yang, H, Lee, JO, Dixon, JE, Di Cristofano, A
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![PTEN R173H [cytosol] icon](/icon/R-ICO-013990.svg){kind=icon}
