Reactome | FTH1 [tertiary granule lumen]

FTH1 [tertiary granule lumen]

Stable Identifier

R-HSA-6801508

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

tertiary granule lumen

Synonyms

Ferritin heavy chain, FRIH_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P02794 FTH1

Gene Names

FTH1, FTH, FTHL6, OK/SW-cl.84, PIG15

Chain

initiator methionine:1, chain:1-183, chain:2-183

Reference Genes

BioGPS Gene:2495 FTH1

COSMIC (genes):FTH1 FTH1

CTD Gene:2495 FTH1

dbSNP Gene:2495 FTH1

ENSEMBL:ENSG00000167996 FTH1

HGNC:3976 FTH1

KEGG Gene (Homo sapiens):2495 FTH1

Monarch:2495 FTH1

NCBI Gene:2495 FTH1

OMIM:134770 FTH1

UCSC:P02794 FTH1

Reference Transcript

RefSeq:NM_002032.2 FTH1

Other Identifiers

11752577_at

11757633_x_at

200748_3p_s_at

200748_s_at

214211_at

2384397

2495

2545844

2545846

2590361

2590364

2629711

2850328

2956776

3142410

31697_s_at

3375649

3375650

3375651

3375652

3375654

3375656

3375657

3375663

3375664

3375665

3375666

33943_at

3505170

3994182

7948656

8170360

A_21_P0013796

A_24_P919330

GE63127

GE81103

GO:0002376

GO:0003674

GO:0004322

GO:0005506

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005764

GO:0005773

GO:0005829

GO:0006810

GO:0006826

GO:0006879

GO:0006880

GO:0006892

GO:0006955

GO:0008043

GO:0008150

GO:0008198

GO:0008199

GO:0008283

GO:0008285

GO:0016192

GO:0016491

GO:0031410

GO:0032991

GO:0042592

GO:0043167

GO:0043226

GO:0043312

GO:0044754

GO:0046872

GO:0048147

GO:0070062

GO:1904724

GO:1904813

Hs.62954.5.A1_3p_x_at

ILMN_1683146

L20941_at

TC11001860.hg

TC11003179.hg

g4503794_3p_s_at

Participates

as a member of

Tertiary granule lumen proteins [tertiary granule lumen] (Homo sapiens)

Other forms of this molecule

FTH1 [endocytic vesicle lumen]

FTH1 [ficolin-1-rich granule lumen]

FTH1 [extracellular region]

FTH1 [cytosol]

Inferred To

Fer3HCH [tertiary granule lumen] (Drosophila melanogaster)

fth1a [tertiary granule lumen] (Danio rerio)

ftn-2 [tertiary granule lumen] (Caenorhabditis elegans)

Fth1 [tertiary granule lumen] (Mus musculus)

Fth1 [tertiary granule lumen] (Rattus norvegicus)

FTH [tertiary granule lumen] (Gallus gallus)

FTH1 [tertiary granule lumen] (Bos taurus)

FTH1 [tertiary granule lumen] (Canis familiaris)

FTH1 [tertiary granule lumen] (Sus scrofa)

FTH1 [tertiary granule lumen] (Xenopus tropicalis)

Homologues of FTH1 [tertiary granule lumen] (Bos taurus)

Homologues of FTH1 [tertiary granule lumen] (Canis familiaris)

Cross References

RefSeq

NP_002023.2

OpenTargets

ENSG00000167996

IntEnz

1.16.3.1

GeneCards

P02794

HPA

ENSG00000167996-FTH1

Ensembl

ENST00000273550, ENSP00000484477, ENSP00000273550, ENST00000620041, ENSG00000167996

PRO

P02794

Pharos - Targets

P02794

GlyGen

P02794

Orphanet

17368

HMDB Protein

HMDBP08672

PDB

6M52, 6J7G, 6Z9F, 6Z9E, 7JGL, 2CHI, 3AJP, 6WYH, 7JGK, 6WYG, 6GSR, 7K26, 6WYF, 6M54, 3AJO, 2FHA, 6FTV, 6B8F, 5CMQ, 1FHA, 4Y08, 5GOU, 4ZJK, 4OYN, 6KE4, 6KE2, 5VTD, 6B8G, 7JGP, 6JOB, 7JGQ, 6IPP, 5ZND, 2CN7, 5JKL, 6IPO, 2CN6, 5JKM, 6H6T, 7K3W, 6H6U, 5YI5, 7K3V, 4YKH, 6IPQ, 4DYX, 6H5I, 2CLU, 4DZ0, 7JGO, 5CMR, 3ERZ, 4DYY, 5UP9, 6JPS, 6J4A, 2IU2, 5UP7, 3AJQ, 2Z6M, 7JGM, 7JGN, 3ES3, 5UP8, 5JKK, 2CEI, 6IPC, 5GN8, 5XB1, 5N27, 4DYZ, 5N26, 6Z6U, 7A6A, 7A6B, 2CIH

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UER7 DAXX	13	DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C74 [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX E104* [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX [nucleoplasm] (R-HSA-3222068) SUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX C106* [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs*72 [nucleoplasm] (R-HSA-9673110)	0.691	5
UniProt:Q92574 TSC1	2	TSC1 [plasma membrane] (R-HSA-165169) TSC1 [cytosol] (R-HSA-5672338)	0.635	3
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126):p-8Y FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126):FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.601	4
UniProt:P04792 HSPB1	3	p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) HSPB1 [cytosol] (R-HSA-450563)	0.508	2

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