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Heparan(4)-GPC1
Stable Identifier
R-HSA-2076605
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
GPC1, Glypican-1, Secreted glypican-1, GPC1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG biosynthesis (Homo sapiens)
NDST1-4 N-deacetylates GlcNAc residues in heparan (Homo sapiens)
Heparan(4)-PGs [Golgi lumen] (Homo sapiens)
Heparan(4)-GPC1 [Golgi lumen] (Homo sapiens)
NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Homo sapiens)
Heparan(4)-PGs [Golgi lumen] (Homo sapiens)
Heparan(4)-GPC1 [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35052 GPC1
Gene Names
GPC1
Chain
signal peptide:1-23, chain:24-530, chain:24-, propeptide:531-558
Reference Genes
BioGPS Gene:2817 GPC1
COSMIC (genes):GPC1 GPC1
CTD Gene:2817 GPC1
dbSNP Gene:2817 GPC1
ENSEMBL:ENSG00000063660 GPC1
HGNC:4449 GPC1
KEGG Gene (Homo sapiens):hsa:2817 GPC1
Monarch:2817 GPC1
NCBI Gene:2817 GPC1
OMIM:600395 GPC1
UCSC:P35052 GPC1
Reference Transcript
RefSeq:NM_002081.2 GPC1
Other Identifiers
0001740280
11717361_a_at
11717362_x_at
16893169
202755_s_at
202756_s_at
2817
30571
33929_at
4ACR
4AD7
4BWE
4YWT
8049670
A_23_P209904
AAH51279
AAY24160
AC110619
AK095397
AK096638
BAG53043
BAG53345
BC051279
CAA38139
CCDS2534
CH471063
EAW71180
EAW71183
ENSG00000063660
ENSP00000264039
ENST00000264039
EntrezGene:2817
g4504080_3p_a_at
GE59792
GO:0000902
GO:0001523
GO:0002376
GO:0003674
GO:0005507
GO:0005575
GO:0005576
GO:0005578
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005764
GO:0005768
GO:0005773
GO:0005794
GO:0005796
GO:0005829
GO:0005886
GO:0005887
GO:0006024
GO:0006027
GO:0006629
GO:0006790
GO:0007165
GO:0007411
GO:0008150
GO:0009056
GO:0009058
GO:0014037
GO:0016020
GO:0017134
GO:0022607
GO:0030154
GO:0030200
GO:0030203
GO:0031225
GO:0031410
GO:0032288
GO:0040011
GO:0040037
GO:0043167
GO:0043202
GO:0043226
GO:0043236
GO:0043395
GO:0044281
GO:0045121
GO:0048646
GO:0048856
GO:0048870
GO:0050900
GO:0070062
GO:2001016
GPC1
GPC1-201
HGNC:4449
HPA030571
Hs.2699.0.S1_3p_a_at
ILMN_1801516
IPR001863
IPR015502
IPR019803
MIM:600395
NM_002081
NP_002072
PF01153
PH_hs_0023823
TC02001464.hg
uc002vyw.5
UPI000013D4AA
X54232
X54232_at
Participant Of
hasMember
Heparan(4)-PGs [Golgi lumen]
Other forms of this molecule
GPC1 [plasma membrane]
GPC1 [lysosomal lumen]
HS(6)-GPC1 [lysosomal lumen]
HS(5)-GPC1 [plasma membrane]
HS(3)-GPC1 [plasma membrane]
HS(1)-GPC1 [plasma membrane]
HS(2)-GPC1 [plasma membrane]
HS(6)-GPC1 [plasma membrane]
HS(4)-GPC1 [plasma membrane]
HS(6)-GPC1 [Golgi lumen]
HS(5)-GPC1 [Golgi lumen]
Heparan-GPC1 [Golgi lumen]
Heparan(1)-GPC1 [Golgi lumen]
XylS-GPC1 [Golgi lumen]
Gal-Xyl-GPC1 [Golgi lumen]
GPC1 [Golgi lumen]
Gal-Gal-Xyl-GPC1 [Golgi lumen]
GlcA-Gal-Gal-Xyl-GPC1 [Golgi lumen]
HS(3)-GPC1 [Golgi lumen]
HS(4)-GPC1 [Golgi lumen]
HS(2)-GPC1 [Golgi lumen]
HS(1)-GPC1 [Golgi lumen]
Heparan(3)-GPC1 [Golgi lumen]
Heparan(2)-GPC1 [Golgi lumen]
Inferred To
Homologues of Heparan(4)-GPC1 [Golgi lumen] (Danio rerio)
Homologues of Heparan(4)-GPC1 [Golgi lumen] (Drosophila melanogaster)
Heparan(4)-GPC1 [Golgi lumen] (Bos taurus)
Heparan(4)-GPC1 [Golgi lumen] (Caenorhabditis elegans)
Heparan(4)-GPC1 [Golgi lumen] (Canis familiaris)
Heparan(4)-GPC1 [Golgi lumen] (Danio rerio)
Heparan(4)-GPC1 [Golgi lumen] (Drosophila melanogaster)
Heparan(4)-GPC1 [Golgi lumen] (Gallus gallus)
Heparan(4)-GPC1 [Golgi lumen] (Mus musculus)
Heparan(4)-GPC1 [Golgi lumen] (Rattus norvegicus)
Heparan(4)-GPC1 [Golgi lumen] (Sus scrofa)
Heparan(4)-GPC1 [Golgi lumen] (Taeniopygia guttata)
Heparan(4)-GPC1 [Golgi lumen] (Xenopus tropicalis)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63651) at unknown position
Modification
beta-D-GlcA-(1->4)-alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcN-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_002072.2
GeneCards
P35052
DOCK Blaster
4AD7
,
4BWE
,
4YWT
,
4ACR
PRO
P35052
Orphanet
22145
PDB
4AD7
,
4ACR
,
4YWT
,
4BWE
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