Reactome | FAS [plasma membrane]

FAS [plasma membrane]

Stable Identifier

R-HSA-66248

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

FAS Receptor, Tumor necrosis factor receptor superfamily member 6 precursor (FASL receptor) (Apoptosis-mediating surface antigen FAS) (Apo-1 antigen) (CD95), Tumor necrosis factor receptor superfamily member 6 precursor, FASL receptor, Apoptosis-mediating surface antigen FAS, Apo-1 antigen, CD95

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Death Receptors and Ligands (Homo sapiens)
        
        TP53 family members stimulate FAS gene expression (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)

Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
    - Caspase activation via Death Receptors in the presence of ligand (Homo sapiens)
      - Caspase-8 processing in the DISC (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8-dimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
      - Dimerization of procaspase-8 (Homo sapiens)
        
        FAS-mediated dimerization of procaspase-8 (Homo sapiens)
        
        FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
      - Regulation by c-FLIP (Homo sapiens)
        
        Caspase-8 and FLIP(L) processing at DISC (Homo sapiens)
        
        DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
- Regulated Necrosis (Homo sapiens)
  - RIPK1-mediated regulated necrosis (Homo sapiens)
    - RIPK3 binds RIPK1 (Homo sapiens)
      - DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
      - DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
    - Regulation of necroptotic cell death (Homo sapiens)
      - CASP8 activity is inhibited (Homo sapiens)
        
        FLIP(L) and procaspase-8 form heterodimer (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        FLIP(S) and procaspase-8 form heterodimer (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P25445 FAS

Gene Names

FAS, APT1, FAS1, TNFRSF6

Chain

signal peptide:1-25, chain:26-335

Reference Genes

BioGPS Gene:355 FAS

COSMIC (genes):FAS FAS

CTD Gene:355 FAS

dbSNP Gene:355 FAS

ENSEMBL:ENSG00000026103 FAS

ENSEMBL_homo_sapiens_GENE:ENSG00000026103 FAS

HGNC:11920 FAS

KEGG Gene (Homo sapiens):355 FAS

Monarch:355 FAS

NCBI Gene:355 FAS

OMIM:134637 FAS

UCSC:P25445 FAS

Reference Transcript

Other Identifiers

0001580156

11725998_a_at

11725999_s_at

1441_s_at

16707149

1808_s_at

1BZI

1DDF

204780_s_at

204781_s_at

215719_x_at

216252_x_at

27444

2NA7

3257101

3257102

3257111

3257115

3257117

3257118

3257119

3257120

3257121

3257122

3257124

3257125

3257126

355

37643_at

37644_s_at

3EWT

3EZQ

3THM

3TJE

7929032

A0A087WTM9

A_14_P120036

A_23_P63896

A_33_P3332112

A_33_P3381127

AAA63174

AAH12479

AAR08906

AAS76663

BAF83667

CAA45250

CAA61473

CAA88031

CAA88032

CAA88033

CAA94430

CAA94431

CAR92543

CCDS7393

CCDS7394

CCDS7395

EAW50151

ENSG00000026103

ENSP00000347426

ENSP00000347979

ENSP00000349896

ENSP00000420975

ENSP00000422453

ENSP00000423755

ENSP00000424113

ENSP00000425159

ENST00000355279

ENST00000355740

ENST00000357339

ENST00000479522

ENST00000484444

ENST00000488877

ENST00000492756

ENST00000494410

EntrezGene:355

FAS

FAS-203

FAS-204

FAS-205

FAS-210

FAS-211

FAS-213

FAS-214

FAS-215

g4507582_3p_a_at

GE59899

GO:0001934

GO:0002376

GO:0003674

GO:0004888

GO:0005515

GO:0005516

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006464

GO:0006915

GO:0006919

GO:0006950

GO:0006955

GO:0007165

GO:0008150

GO:0008219

GO:0009986

GO:0016020

GO:0016021

GO:0016604

GO:0019899

GO:0019900

GO:0022607

GO:0031264

GO:0031265

GO:0032872

GO:0032991

GO:0034198

GO:0036337

GO:0038023

GO:0042802

GO:0042981

GO:0043065

GO:0043066

GO:0043226

GO:0045121

GO:0065003

GO:0070062

GO:0071260

GO:0071455

GO:0097190

GO:0097191

GO:0097527

GO:1902041

GO:1902042

GO:2001235

GO:2001269

H7C5Z8

HGNC:11920

HPA027444

Hs.82359.0.S1_3p_a_at

Hs.82359.1.S1_3p_a_at

ILMN_1808132

ILMN_2319077

IPR000488

IPR001368

IPR008063

IPR011029

IPR033998

IPR033999

LRG_134

MIM:134637

MIM:601859

NM_000043

NM_152871

NM_152872

NP_000034

NP_690610

NP_690611

NR_028033

NR_028034

NR_028035

NR_028036

NR_135313

PF00020

PF00531

PH_hs_0004717

PR01680

SM00005

SM00208

TC10002196.hg

uc001kfr.4

uc001kfs.4

uc001kft.4

uc001kfw.4

uc057utn.1

uc057uto.1

uc057utp.1

uc057utq.1

UPI000002B58E

UPI000002B58F

UPI000002B590

UPI000002B591

UPI000002B592

UPI000003060C

UPI0000163948

X63717_at

X83492_at

X83492_s_at

X89101_s_at

XM_006717819

XM_011539764

XM_011539765

XM_011539766

XM_011539767

XP_006717882

XP_011538066

XP_011538067

XP_011538068

XP_011538069

Participant Of

input

FASL binds FAS Receptor

output

TP53 family members stimulate FAS gene expression

hasComponent

FASL:FAS Receptor monomer [plasma membrane]

Inferred To

FAS [plasma membrane] (Bos taurus)

FAS [plasma membrane] (Canis familiaris)

FAS [plasma membrane] (Danio rerio)

FAS [plasma membrane] (Gallus gallus)

FAS [plasma membrane] (Mus musculus)

FAS [plasma membrane] (Rattus norvegicus)

FAS [plasma membrane] (Sus scrofa)

FAS [plasma membrane] (Taeniopygia guttata)

FAS [plasma membrane] (Xenopus tropicalis)

Homologues of FAS [plasma membrane] (Canis familiaris)

Homologues of FAS [plasma membrane] (Taeniopygia guttata)

Homologues of FAS [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_000034.1, NP_001307548.1, NP_690610.1, NP_690611.1

OpenTargets

ENSG00000026103

GeneCards

P25445

DOCK Blaster

3EWT, 3TJE, 3THM, 3EZQ

PRO

P25445

Orphanet

16029

PDB

1DDF, 3EWT, 3EZQ, 3TJE, 2NA7, 1BZI, 3THM

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13158 FADD	1	FADD [cytosol] (R-HSA-54639)	0.959	22
UniProt:Q14790 CASP8	8	CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(1-479) [cytosol] (R-HSA-57031) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(217-374) [cytosol] (R-HSA-75975)	0.911	15
UniProt:Q9UER7 DAXX	2	DAXX [nucleoplasm] (R-HSA-3222068) SUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.702	3
UniProt:P48023 FASLG	1	FASLG(1-281) [extracellular region] (R-HSA-66212)	0.688	4
UniProt:P25445 FAS	1	FAS [plasma membrane] (R-HSA-66248)	0.681	3
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.589	2
UniProt:Q12923 PTPN13	2	PTPN13 [nucleoplasm] (R-HSA-9008915) PTPN13 [plasma membrane] (R-HSA-8870318)	0.589	3
UniProt:P0DP25 CALM			0.576	4
UniProt:Q15156 Q15156			0.576	6
UniProt:P29590 PML	5	SUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) SUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386) SUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) PML [nucleoplasm] (R-HSA-1031706) PML [cytosol] (R-HSA-5624327)	0.524	4
UniProt:P12815 PDCD6			0.508	2
UniProt:Q03135 CAV1	5	CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [endocytic vesicle membrane] (R-HSA-535009) CAV1 [lipid droplet] (R-HSA-163510)	0.463	3