Reactome | FAS [plasma membrane]

FAS [plasma membrane]

Stable Identifier

R-HSA-66248

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

FAS Receptor, Tumor necrosis factor receptor superfamily member 6 precursor (FASL receptor) (Apoptosis-mediating surface antigen FAS) (Apo-1 antigen) (CD95), Tumor necrosis factor receptor superfamily member 6 precursor, FASL receptor, Apoptosis-mediating surface antigen FAS, Apo-1 antigen, CD95

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Death Receptors and Ligands (Homo sapiens)
        
        TP53 family members stimulate FAS gene expression (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)

Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
    - Caspase activation via Death Receptors in the presence of ligand (Homo sapiens)
      - Caspase-8 processing in the DISC (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8-dimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
      - Dimerization of procaspase-8 (Homo sapiens)
        
        FAS-mediated dimerization of procaspase-8 (Homo sapiens)
        
        FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
      - Regulation by c-FLIP (Homo sapiens)
        
        Caspase-8 and FLIP(L) processing at DISC (Homo sapiens)
        
        DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
- Regulated Necrosis (Homo sapiens)
  - RIPK1-mediated regulated necrosis (Homo sapiens)
    - RIPK3 binds RIPK1 (Homo sapiens)
      - DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
      - DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
    - Regulation of necroptotic cell death (Homo sapiens)
      - CASP8 activity is inhibited (Homo sapiens)
        
        FLIP(L) and procaspase-8 form heterodimer (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        FLIP(S) and procaspase-8 form heterodimer (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P25445 FAS

Gene Names

FAS, APT1, FAS1, TNFRSF6

Chain

signal peptide:1-25, chain:26-335

Reference Genes

BioGPS Gene:355 FAS

COSMIC (genes):FAS FAS

CTD Gene:355 FAS

dbSNP Gene:355 FAS

ENSEMBL:ENSG00000026103 FAS

HGNC:11920 FAS

KEGG:hsa:355 FAS

Monarch:355 FAS

NCBI Gene:355 FAS

OMIM:134637 FAS

UCSC:P25445 FAS

Reference Transcript

Participates

as an output of

TP53 family members stimulate FAS gene expression (Homo sapiens)

as an input of

FASL binds FAS Receptor (Homo sapiens)

as a component of

FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)

Inferred To

Fas [plasma membrane] (Mus musculus)

Fas [plasma membrane] (Rattus norvegicus)

fas [plasma membrane] (Xenopus tropicalis)

FAS [plasma membrane] (Bos taurus)

FAS [plasma membrane] (Canis familiaris)

FAS [plasma membrane] (Gallus gallus)

FAS [plasma membrane] (Sus scrofa)

Homologues of FAS [plasma membrane] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

1875

OpenTargets

ENSG00000026103

ENSEMBL

ENST00000488877, ENST00000357339, ENSP00000513060, ENST00000697036, ENST00000484444, ENST00000492756, ENSP00000422453, ENST00000479522, ENSG00000026103, ENSP00000424113, ENST00000494410, ENSP00000423755, ENSP00000425159, ENSP00000347426, ENSP00000420975, ENST00000355279, ENST00000652046, ENSP00000498466, ENSP00000349896

HPA

ENSG00000026103-FAS

GeneCards

FAS

PRO

P25445

Pharos - Targets

P25445

GlyGen

P25445

Orphanet

FAS

PDB

3THM, 3TJE, 1DDF, 3EZQ, 3EWT, 2NA7

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13158 FADD	1	FADD [cytosol] (R-HSA-54639)	0.96	23
UniProt:Q14790 CASP8	8	CASP8(1-479) [cytosol] (R-HSA-57031) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(1-374) [cytosol] (R-HSA-3465404)	0.92	16
UniProt:P25445 FAS	1	FAS [plasma membrane] (R-HSA-66248)	0.681	3
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.674	3
UniProt:P48023 FASLG	1	FASLG(1-281) [extracellular region] (R-HSA-66212)	0.65	4
UniProt:Q12923 PTPN13	2	PTPN13 [nucleoplasm] (R-HSA-9008915) PTPN13 [plasma membrane] (R-HSA-8870318)	0.589	3
UniProt:Q15156 Q15156			0.576	6
UniProt:P62158 CALM			0.576	4
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.536	2
UniProt:Q8NB90 AFG2A			0.527	2
UniProt:Q9BVQ7 AFG2B			0.527	3
UniProt:P29590 PML	5	PML [cytosol] (R-HSA-5624327) PML [nucleoplasm] (R-HSA-1031706) monoSUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) polySUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) polySUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386)	0.524	4
UniProt:P12815 PDCD6			0.508	2
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009)	0.463	3

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