Reactome | FAS [plasma membrane]

FAS [plasma membrane]

Stable Identifier

R-HSA-66248

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

FAS Receptor, Tumor necrosis factor receptor superfamily member 6 precursor (FASL receptor) (Apoptosis-mediating surface antigen FAS) (Apo-1 antigen) (CD95), Tumor necrosis factor receptor superfamily member 6 precursor, FASL receptor, Apoptosis-mediating surface antigen FAS, Apo-1 antigen, CD95

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Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Death Receptors and Ligands (Homo sapiens)
        
        TP53 family members stimulate FAS gene expression (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)

Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
    - Caspase activation via Death Receptors in the presence of ligand (Homo sapiens)
      - Caspase-8 processing in the DISC (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8-dimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
      - Dimerization of procaspase-8 (Homo sapiens)
        
        FAS-mediated dimerization of procaspase-8 (Homo sapiens)
        
        FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
      - Regulation by c-FLIP (Homo sapiens)
        
        Caspase-8 and FLIP(L) processing at DISC (Homo sapiens)
        
        DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
- Regulated Necrosis (Homo sapiens)
  - RIPK1-mediated regulated necrosis (Homo sapiens)
    - RIPK3 binds RIPK1 (Homo sapiens)
      - DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
      - DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
    - Regulation of necroptotic cell death (Homo sapiens)
      - CASP8 activity is inhibited (Homo sapiens)
        
        FLIP(L) and procaspase-8 form heterodimer (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        FLIP(S) and procaspase-8 form heterodimer (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P25445 FAS

Gene Names

FAS, APT1, FAS1, TNFRSF6

Chain

signal peptide:1-25, chain:26-335

Reference Genes

BioGPS Gene:355 FAS

COSMIC (genes):FAS FAS

CTD Gene:355 FAS

dbSNP Gene:355 FAS

ENSEMBL:ENSG00000026103 FAS

HGNC:11920 FAS

KEGG Gene (Homo sapiens):355 FAS

Monarch:355 FAS

NCBI Gene:355 FAS

OMIM:134637 FAS

UCSC:P25445 FAS

Reference Transcript

Other Identifiers

0001580156

0101660053

11725998_a_at

11725999_s_at

1441_s_at

16707149

1808_s_at

204780_s_at

204781_s_at

215719_x_at

216252_x_at

233820_at

3257101

3257102

3257111

3257115

3257117

3257118

3257119

3257120

3257121

3257122

3257124

3257125

3257126

3257128

3257130

355

37643_at

37644_s_at

389_s_at

7929032

A_14_P120036

A_23_P63896

A_24_P937817

A_33_P3332112

A_33_P3381127

GE515051

GE59899

GO:0001934

GO:0002376

GO:0003674

GO:0004888

GO:0005031

GO:0005515

GO:0005516

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006464

GO:0006915

GO:0006919

GO:0006924

GO:0006950

GO:0006955

GO:0007165

GO:0008150

GO:0008219

GO:0009897

GO:0009986

GO:0016020

GO:0016021

GO:0016604

GO:0019899

GO:0019900

GO:0022607

GO:0031264

GO:0031265

GO:0032872

GO:0032991

GO:0033209

GO:0034198

GO:0036337

GO:0038023

GO:0042592

GO:0042802

GO:0042981

GO:0043065

GO:0043066

GO:0043226

GO:0045121

GO:0065003

GO:0070062

GO:0071260

GO:0071455

GO:0097049

GO:0097190

GO:0097191

GO:0097192

GO:0097527

GO:1902041

GO:1902042

GO:2001235

GO:2001269

HMNXSV003033285

HMNXSV003035786

HMNXSV003056741

Hs.146747.0.S1_3p_at

Hs.82359.0.S1_3p_a_at

Hs.82359.1.S1_3p_a_at

ILMN_1808132

ILMN_1910834

ILMN_2319077

PH_hs_0004717

PH_hs_0008764

TC10002196.hg

TC10002197.hg

X63717_at

X82279_s_at

X83492_at

X83492_s_at

X89101_s_at

g4507582_3p_a_at

Participates

as an output of

TP53 family members stimulate FAS gene expression (Homo sapiens)

as an input of

FASL binds FAS Receptor (Homo sapiens)

as a component of

FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)

Inferred To

Fas [plasma membrane] (Mus musculus)

Fas [plasma membrane] (Rattus norvegicus)

fas [plasma membrane] (Danio rerio)

fas [plasma membrane] (Xenopus tropicalis)

FAS [plasma membrane] (Bos taurus)

FAS [plasma membrane] (Canis familiaris)

FAS [plasma membrane] (Gallus gallus)

FAS [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_690610.1, NP_690611.1, NP_000034.1, NP_001307548.1

Guide to Pharmacology - Targets

1875

OpenTargets

ENSG00000026103

GeneCards

P25445

HPA

ENSG00000026103-FAS

Ensembl

ENST00000492756, ENSG00000026103, ENSP00000498466, ENST00000355279, ENSP00000349896, ENSP00000425159, ENSP00000422453, ENSP00000420975, ENST00000488877, ENSP00000424113, ENSP00000423755, ENST00000357339, ENST00000484444, ENST00000479522, ENST00000652046, ENSP00000347426, ENST00000494410

PRO

P25445

Pharos - Targets

P25445

Orphanet

16029

GlyGen

P25445

PDB

2NA7, 1DDF, 3TJE, 3EWT, 3THM, 3EZQ

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13158 FADD	1	FADD [cytosol] (R-HSA-54639)	0.958	22
UniProt:Q14790 CASP8	8	CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031)	0.911	15
UniProt:P25445 FAS	1	FAS [plasma membrane] (R-HSA-66248)	0.681	3
UniProt:Q9UER7 DAXX	13	monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX S138* [nucleoplasm] (R-HSA-9673081) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A36Qfs*108 [nucleoplasm] (R-HSA-9673105) DAXX [nucleoplasm] (R-HSA-3222068)	0.674	3
UniProt:P48023 FASLG	1	FASLG(1-281) [extracellular region] (R-HSA-66212)	0.65	4
UniProt:Q12923 PTPN13	2	PTPN13 [plasma membrane] (R-HSA-8870318) PTPN13 [nucleoplasm] (R-HSA-9008915)	0.589	3
UniProt:P62158 CALM			0.576	4
UniProt:Q15156 Q15156			0.576	6
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.536	2
UniProt:P29590 PML	5	polySUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386) polySUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) monoSUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) PML [cytosol] (R-HSA-5624327) PML [nucleoplasm] (R-HSA-1031706)	0.524	4
UniProt:P12815 PDCD6			0.508	2
UniProt:Q03135 CAV1	5	CAV1 [plasma membrane] (R-HSA-534994) CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009)	0.463	3

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