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FAS [plasma membrane]
Stable Identifier
R-HSA-66248
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
FAS Receptor, Tumor necrosis factor receptor superfamily member 6 precursor (FASL receptor) (Apoptosis-mediating surface antigen FAS) (Apo-1 antigen) (CD95), Tumor necrosis factor receptor superfamily member 6 precursor, FASL receptor, Apoptosis-mediating surface antigen FAS, Apo-1 antigen, CD95
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
TP53 Regulates Transcription of Death Receptors and Ligands (Homo sapiens)
TP53 family members stimulate FAS gene expression (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
Caspase activation via Death Receptors in the presence of ligand (Homo sapiens)
Caspase-8 processing in the DISC (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
DISC:procaspase-8-dimer [plasma membrane] (Homo sapiens)
FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
Dimerization of procaspase-8 (Homo sapiens)
FAS-mediated dimerization of procaspase-8 (Homo sapiens)
FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
Regulation by c-FLIP (Homo sapiens)
Caspase-8 and FLIP(L) processing at DISC (Homo sapiens)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Homo sapiens)
FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
RIPK3 binds RIPK1 (Homo sapiens)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
Regulation of necroptotic cell death (Homo sapiens)
CASP8 activity is inhibited (Homo sapiens)
FLIP(L) and procaspase-8 form heterodimer (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
FLIP(S) and procaspase-8 form heterodimer (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
FasL/ CD95L signaling (Homo sapiens)
FASL binds FAS Receptor (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD:pro-Caspase-10 [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
FasL:Fas binds FADD (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
Trimerization of the FASL:FAS receptor complex (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P25445 FAS
Gene Names
FAS, APT1, FAS1, TNFRSF6
Chain
signal peptide:1-25, chain:26-335
Reference Genes
BioGPS Gene:355 FAS
COSMIC (genes):FAS FAS
CTD Gene:355 FAS
dbSNP Gene:355 FAS
ENSEMBL:ENSG00000026103 FAS
HGNC:11920 FAS
KEGG:hsa:355 FAS
Monarch:355 FAS
NCBI Gene:355 FAS
OMIM:134637 FAS
UCSC:P25445 FAS
Reference Transcript
RefSeq:NM_001320619.1 FAS
RefSeq:NM_152871.3 FAS
RefSeq:NM_000043.5 FAS
RefSeq:NM_152872.3 FAS
Participates
as an output of
TP53 family members stimulate FAS gene expression (Homo sapiens)
as an input of
FASL binds FAS Receptor (Homo sapiens)
as a component of
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
Inferred To
Fas [plasma membrane]
(Mus musculus)
Fas [plasma membrane]
(Rattus norvegicus)
fas [plasma membrane]
(Xenopus tropicalis)
FAS [plasma membrane]
(Bos taurus)
FAS [plasma membrane]
(Canis familiaris)
FAS [plasma membrane]
(Gallus gallus)
FAS [plasma membrane]
(Sus scrofa)
Homologues of FAS [plasma membrane]
(Sus scrofa)
Cross References
Guide to Pharmacology - Targets
1875
OpenTargets
ENSG00000026103
ENSEMBL
ENST00000488877
,
ENST00000357339
,
ENSP00000513060
,
ENST00000697036
,
ENST00000484444
,
ENST00000492756
,
ENSP00000422453
,
ENST00000479522
,
ENSG00000026103
,
ENSP00000424113
,
ENST00000494410
,
ENSP00000423755
,
ENSP00000425159
,
ENSP00000347426
,
ENSP00000420975
,
ENST00000355279
,
ENST00000652046
,
ENSP00000498466
,
ENSP00000349896
HPA
ENSG00000026103-FAS
GeneCards
FAS
PRO
P25445
Pharos - Targets
P25445
GlyGen
P25445
Orphanet
FAS
PDB
3THM
,
3TJE
,
1DDF
,
3EZQ
,
3EWT
,
2NA7
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13158 FADD
1
FADD [cytosol]
(R-HSA-54639)
0.96
23
UniProt:Q14790 CASP8
8
CASP8(1-479) [cytosol]
(R-HSA-57031)
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(217-374) [cytosol]
(R-HSA-75975)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(1-374) [cytosol]
(R-HSA-3465404)
0.92
16
UniProt:P25445 FAS
1
FAS [plasma membrane]
(R-HSA-66248)
0.681
3
UniProt:Q9UER7 DAXX
13
DAXX [nucleoplasm]
(R-HSA-3222068)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
0.674
3
UniProt:P48023 FASLG
1
FASLG(1-281) [extracellular region]
(R-HSA-66212)
0.65
4
UniProt:Q12923 PTPN13
2
PTPN13 [nucleoplasm]
(R-HSA-9008915)
PTPN13 [plasma membrane]
(R-HSA-8870318)
0.589
3
UniProt:Q15156 Q15156
0.576
6
UniProt:P62158 CALM
0.576
4
UniProt:Q99683 MAP3K5
1
MAP3K5 [cytosol]
(R-HSA-167709)
0.536
2
UniProt:Q8NB90 AFG2A
0.527
2
UniProt:Q9BVQ7 AFG2B
0.527
3
UniProt:P29590 PML
5
PML [cytosol]
(R-HSA-5624327)
PML [nucleoplasm]
(R-HSA-1031706)
monoSUMO1-K65,160,490-PML [nucleoplasm]
(R-HSA-3000440)
polySUMO2-K65,K160,K490-PML [nucleoplasm]
(R-HSA-3000423)
polySUMO3-K65,K160,K490-PML [nucleoplasm]
(R-HSA-3000386)
0.524
4
UniProt:P12815 PDCD6
0.508
2
UniProt:Q03135 CAV1
5
CAV1 [Golgi membrane]
(R-HSA-204504)
CAV1 [plasma membrane]
(R-HSA-534994)
CAV1 [early endosome membrane]
(R-HSA-5368451)
CAV1 [lipid droplet]
(R-HSA-163510)
CAV1 [endocytic vesicle membrane]
(R-HSA-535009)
0.463
3
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