Reactome | FAS [plasma membrane]

FAS [plasma membrane]

Stable Identifier

R-HSA-66248

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

FAS Receptor, Tumor necrosis factor receptor superfamily member 6 precursor (FASL receptor) (Apoptosis-mediating surface antigen FAS) (Apo-1 antigen) (CD95), Tumor necrosis factor receptor superfamily member 6 precursor, FASL receptor, Apoptosis-mediating surface antigen FAS, Apo-1 antigen, CD95

Icon

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Death Receptors and Ligands (Homo sapiens)
        
        TP53 family members stimulate FAS gene expression (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)

Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
    - Caspase activation via Death Receptors in the presence of ligand (Homo sapiens)
      - Caspase-8 processing in the DISC (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8-dimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
      - Dimerization of procaspase-8 (Homo sapiens)
        
        FAS-mediated dimerization of procaspase-8 (Homo sapiens)
        
        FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
      - Regulation by c-FLIP (Homo sapiens)
        
        Caspase-8 and FLIP(L) processing at DISC (Homo sapiens)
        
        DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
- Regulated Necrosis (Homo sapiens)
  - RIPK1-mediated regulated necrosis (Homo sapiens)
    - RIPK3 binds RIPK1 (Homo sapiens)
      - DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
      - DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
    - Regulation of necroptotic cell death (Homo sapiens)
      - CASP8 activity is inhibited (Homo sapiens)
        
        FLIP(L) and procaspase-8 form heterodimer (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        FLIP(S) and procaspase-8 form heterodimer (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
        
        DISC:procaspase-8 [plasma membrane] (Homo sapiens)
        
        DISC [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
        
        FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
        
        FAS [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P25445 FAS

Gene Names

FAS, APT1, FAS1, TNFRSF6

Chain

signal peptide:1-25, chain:26-335

Reference Genes

BioGPS Gene:355 FAS

COSMIC (genes):FAS FAS

CTD Gene:355 FAS

dbSNP Gene:355 FAS

ENSEMBL:ENSG00000026103 FAS

HGNC:11920 FAS

KEGG Gene (Homo sapiens):355 FAS

Monarch:355 FAS

NCBI Gene:355 FAS

OMIM:134637 FAS

UCSC:P25445 FAS

Reference Transcript

Other Identifiers

0001580156

0101660053

11725998_a_at

11725999_s_at

1441_s_at

16707149

1808_s_at

204780_s_at

204781_s_at

215719_x_at

216252_x_at

233820_at

3257101

3257102

3257111

3257115

3257117

3257118

3257119

3257120

3257121

3257122

3257124

3257125

3257126

3257128

3257130

355

37643_at

37644_s_at

389_s_at

7929032

A_14_P120036

A_23_P63896

A_24_P937817

A_33_P3332112

A_33_P3381127

GE515051

GE59899

GO:0001934

GO:0002376

GO:0003674

GO:0004888

GO:0005031

GO:0005515

GO:0005516

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006464

GO:0006915

GO:0006919

GO:0006924

GO:0006950

GO:0006955

GO:0007165

GO:0008150

GO:0008219

GO:0009897

GO:0009986

GO:0016020

GO:0016021

GO:0016604

GO:0019899

GO:0019900

GO:0022607

GO:0031264

GO:0031265

GO:0032872

GO:0032991

GO:0033209

GO:0034198

GO:0036337

GO:0038023

GO:0042592

GO:0042802

GO:0042981

GO:0043065

GO:0043066

GO:0043226

GO:0045121

GO:0065003

GO:0070062

GO:0071260

GO:0071455

GO:0097049

GO:0097190

GO:0097191

GO:0097192

GO:0097527

GO:1902041

GO:1902042

GO:2001235

GO:2001269

HMNXSV003033285

HMNXSV003035786

HMNXSV003056741

Hs.146747.0.S1_3p_at

Hs.82359.0.S1_3p_a_at

Hs.82359.1.S1_3p_a_at

ILMN_1808132

ILMN_1910834

ILMN_2319077

PH_hs_0004717

PH_hs_0008764

TC10002196.hg

TC10002197.hg

X63717_at

X82279_s_at

X83492_at

X83492_s_at

X89101_s_at

g4507582_3p_a_at

Participates

as an output of

TP53 family members stimulate FAS gene expression (Homo sapiens)

as an input of

FASL binds FAS Receptor (Homo sapiens)

as a component of

FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)

Inferred To

Fas [plasma membrane] (Mus musculus)

Fas [plasma membrane] (Rattus norvegicus)

fas [plasma membrane] (Danio rerio)

fas [plasma membrane] (Xenopus tropicalis)

FAS [plasma membrane] (Bos taurus)

FAS [plasma membrane] (Canis familiaris)

FAS [plasma membrane] (Gallus gallus)

FAS [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_001307548.1, NP_000034.1, NP_690611.1, NP_690610.1

OpenTargets

ENSG00000026103

HPA

ENSG00000026103-FAS

GeneCards

P25445

Ensembl

ENST00000479522, ENSP00000349896, ENST00000492756, ENSP00000424113, ENST00000652046, ENSP00000423755, ENSP00000347426, ENST00000488877, ENST00000357339, ENST00000494410, ENSP00000420975, ENST00000355279, ENSP00000498466, ENSP00000425159, ENSP00000422453, ENST00000484444, ENSG00000026103

PRO

P25445

Orphanet

16029

PDB

3EWT, 1BZI, 2NA7, 1DDF, 3EZQ, 3TJE, 3THM

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13158 FADD	1	FADD [cytosol] (R-HSA-54639)	0.958	22
UniProt:Q14790 CASP8	8	CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(1-479) [cytosol] (R-HSA-57031) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(217-374) [cytosol] (R-HSA-75975)	0.911	15
UniProt:P25445 FAS	1	FAS [plasma membrane] (R-HSA-66248)	0.681	3
UniProt:Q9UER7 DAXX	13	DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) SUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX S138* [nucleoplasm] (R-HSA-9673081) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A36Qfs*108 [nucleoplasm] (R-HSA-9673105) DAXX [nucleoplasm] (R-HSA-3222068)	0.674	3
UniProt:P48023 FASLG	1	FASLG(1-281) [extracellular region] (R-HSA-66212)	0.65	4
UniProt:Q12923 PTPN13	2	PTPN13 [nucleoplasm] (R-HSA-9008915) PTPN13 [plasma membrane] (R-HSA-8870318)	0.589	3
UniProt:Q15156 Q15156			0.576	6
UniProt:P0DP25 CALM			0.576	4
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.536	2
UniProt:P29590 PML	5	SUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) SUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386) SUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) PML [cytosol] (R-HSA-5624327) PML [nucleoplasm] (R-HSA-1031706)	0.524	4
UniProt:P12815 PDCD6			0.508	2
UniProt:Q03135 CAV1	5	CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009)	0.463	3

Cite Us!