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FAS
Stable Identifier
R-HSA-66248
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
FAS Receptor, Tumor necrosis factor receptor superfamily member 6 precursor (FASL receptor) (Apoptosis-mediating surface antigen FAS) (Apo-1 antigen) (CD95), Tumor necrosis factor receptor superfamily member 6 precursor, FASL receptor, Apoptosis-mediating surface antigen FAS, Apo-1 antigen, CD95
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
TP53 Regulates Transcription of Death Receptors and Ligands (Homo sapiens)
TP53 family members stimulate FAS gene expression (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
Ligand-dependent caspase activation (Homo sapiens)
Caspase-8 processing in the DISC (Homo sapiens)
DISC [plasma membrane, cytosol] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
DISC:procaspase-8-dimer [plasma membrane, cytosol] (Homo sapiens)
FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
Dimerization of procaspase-8 (Homo sapiens)
FAS-mediated dimerization of procaspase-8 (Homo sapiens)
FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
Regulation by c-FLIP (Homo sapiens)
Caspase-8 and FLIP(L) processing at DISC (Homo sapiens)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Homo sapiens)
DISC [plasma membrane, cytosol] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane, cytosol] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Homo sapiens)
FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
RIPK3 binds RIPK1 (Homo sapiens)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane, cytosol] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane, cytosol] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
Regulation of necroptotic cell death (Homo sapiens)
CASP8 activity is inhibited (Homo sapiens)
FLIP(L) and procaspase-8 form heterodimer (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane, cytosol] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane, cytosol] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
FLIP(S) and procaspase-8 form heterodimer (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane, cytosol] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Homo sapiens)
DISC:procaspase-8 [plasma membrane] (Homo sapiens)
DISC [plasma membrane, cytosol] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signalling (Homo sapiens)
FasL/ CD95L signaling (Homo sapiens)
FASL binds FAS Receptor (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD:pro-Caspase-10 [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
FasL:Fas binds FADD (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
Trimerization of the FASL:FAS receptor complex (Homo sapiens)
FASL:FAS Receptor Trimer [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
FASL:FAS Receptor monomer [plasma membrane] (Homo sapiens)
FAS [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P25445 FAS
Gene Names
FAS, APT1, FAS1, TNFRSF6
Chain
signal peptide:1-25, chain:26-335
Reference Genes
BioGPS Gene:355 FAS
COSMIC (genes):FAS FAS
CTD Gene:355 FAS
dbSNP Gene:355 FAS
ENSEMBL:ENSG00000026103 FAS
HGNC:11920 FAS
KEGG Gene (Homo sapiens):hsa:355 FAS
Monarch:355 FAS
NCBI Gene:355 FAS
OMIM:134637 FAS
UCSC:P25445 FAS
Reference Transcript
RefSeq:NM_152871.3 FAS
RefSeq:NM_000043.5 FAS
RefSeq:NM_001320619.1 FAS
RefSeq:NM_152872.3 FAS
Other Identifiers
0001580156
0101660053
11725998_a_at
11725999_s_at
1441_s_at
16707149
1808_s_at
1BZI
1DDF
204780_s_at
204781_s_at
215719_x_at
216252_x_at
233820_at
27444
2NA7
3257101
3257102
3257111
3257115
3257117
3257118
3257119
3257120
3257121
3257122
3257124
3257125
3257126
3257128
355
37643_at
37644_s_at
3EWT
3EZQ
3THM
3TJE
7929032
A_14_P120036
A_23_P63896
A_24_P937817
A_33_P3332112
A_33_P3381127
AAA63174
AAH12479
AAR08906
AAS76663
AK290978
AL157394
AY450925
AY495076
BAF83667
BC012479
CAA45250
CAA61473
CAA88031
CAA88032
CAA88033
CAA94430
CAA94431
CAI13870
CAI13871
CAI13872
CAR92543
CCDS7393
CCDS7394
CCDS7395
CH471066
EAW50151
ENSG00000026103
ENSP00000347426
ENSP00000347979
ENSP00000349896
ENSP00000420975
ENSP00000422453
ENSP00000423755
ENSP00000424113
ENSP00000425159
ENST00000355279
ENST00000355740
ENST00000357339
ENST00000479522
ENST00000484444
ENST00000488877
ENST00000492756
ENST00000494410
EntrezGene:355
FAS
FAS-203
FAS-204
FAS-205
FAS-210
FAS-211
FAS-213
FAS-214
FAS-215
FM246458
g4507582_3p_a_at
GE515051
GE59899
GO:0001934
GO:0002377
GO:0003014
GO:0004871
GO:0004872
GO:0004888
GO:0005031
GO:0005515
GO:0005516
GO:0005576
GO:0005739
GO:0005829
GO:0005886
GO:0005887
GO:0006461
GO:0006915
GO:0006919
GO:0006924
GO:0006925
GO:0006954
GO:0006955
GO:0007165
GO:0007275
GO:0007623
GO:0008625
GO:0009636
GO:0009897
GO:0009986
GO:0010467
GO:0016020
GO:0016021
GO:0016604
GO:0019724
GO:0019900
GO:0031264
GO:0031265
GO:0032464
GO:0032496
GO:0032872
GO:0033209
GO:0034198
GO:0036337
GO:0042127
GO:0042802
GO:0042981
GO:0043029
GO:0043065
GO:0043066
GO:0043120
GO:0045060
GO:0045121
GO:0045619
GO:0045637
GO:0048536
GO:0050869
GO:0051260
GO:0051384
GO:0051402
GO:0070062
GO:0070230
GO:0071260
GO:0071285
GO:0071455
GO:0097049
GO:0097190
GO:0097191
GO:0097192
GO:0097284
GO:0097296
GO:0097527
GO:1902041
GO:1902042
GO:2001235
GO:2001238
GO:2001241
GO:2001269
HGNC:11920
HPA027444
Hs.146747.0.S1_3p_at
Hs.82359.0.S1_3p_a_at
Hs.82359.1.S1_3p_a_at
ILMN_1808132
ILMN_1910834
ILMN_2319077
IPR000488
IPR001368
IPR008063
IPR011029
LRG_134
M67454
MIM:134637
MIM:601859
NM_000043
NM_152871
NM_152872
NP_000034
NP_690610
NP_690611
NR_028033
NR_028034
NR_028035
NR_028036
NR_135313
PF00020
PF00531
PH_hs_0004717
PH_hs_0008764
PR01680
SM00005
SM00208
TC10002196.hg
TC10002197.hg
uc001kfr.4
uc001kfs.4
uc001kft.4
uc001kfw.4
uc057utn.1
uc057uto.1
uc057utp.1
uc057utq.1
UPI000002B58E
UPI000002B58F
UPI000002B590
UPI000002B591
UPI000002B592
UPI000003060C
UPI0000163948
X63717
X63717_at
X83490
X83491
X83492
X83492_at
X83492_s_at
X83493
X89101
X89101_s_at
XM_006717819
XM_011539764
XM_011539765
XM_011539766
XM_011539767
XP_006717882
XP_011538066
XP_011538067
XP_011538068
XP_011538069
Z47993
Z47994
Z47995
Z66556
Z70519
Z70520
Participant Of
input
FASL binds FAS Receptor
hasComponent
FASL:FAS Receptor monomer [plasma membrane]
output
TP53 family members stimulate FAS gene expression
Inferred To
FAS [plasma membrane] (Bos taurus)
FAS [plasma membrane] (Canis familiaris)
FAS [plasma membrane] (Danio rerio)
FAS [plasma membrane] (Gallus gallus)
FAS [plasma membrane] (Mus musculus)
FAS [plasma membrane] (Rattus norvegicus)
FAS [plasma membrane] (Sus scrofa)
FAS [plasma membrane] (Taeniopygia guttata)
FAS [plasma membrane] (Xenopus tropicalis)
Homologues of FAS [plasma membrane] (Canis familiaris)
Homologues of FAS [plasma membrane] (Danio rerio)
Homologues of FAS [plasma membrane] (Taeniopygia guttata)
Homologues of FAS [plasma membrane] (Xenopus tropicalis)
Cross References
RefSeq
NP_001307548.1
,
NP_690610.1
,
NP_690611.1
,
NP_000034.1
GeneCards
P25445
DOCK Blaster
3EWT
,
3THM
,
3EZQ
,
3TJE
PRO
P25445
Orphanet
16029
PDB
1BZI
,
3THM
,
3TJE
,
1DDF
,
2NA7
,
3EWT
,
3EZQ
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13158 FADD
1
FADD [cytosol]
(R-HSA-54639)
0.959
22
UniProt:Q14790 CASP8
8
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(1-374) [cytosol]
(R-HSA-3465404)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(1-479) [cytosol]
(R-HSA-57031)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(217-374) [cytosol]
(R-HSA-75975)
0.911
15
UniProt:Q9UER7 DAXX
1
DAXX [nucleoplasm]
(R-HSA-3222068)
0.702
3
UniProt:P48023 FASLG
1
FASLG(1-281) [extracellular region]
(R-HSA-66212)
0.688
4
UniProt:P25445 FAS
1
FAS [plasma membrane]
(R-HSA-66248)
0.681
3
UniProt:Q12923 PTPN13
2
PTPN13 [nucleoplasm]
(R-HSA-9008915)
PTPN13 [plasma membrane]
(R-HSA-8870318)
0.589
3
UniProt:Q99683 MAP3K5
1
MAP3K5 [cytosol]
(R-HSA-167709)
0.589
2
UniProt:P62158 CALM
0.576
4
UniProt:Q15156 Q15156
0.576
6
UniProt:P29590 PML
5
SUMO2-K65,K160,K490-PML [nucleoplasm]
(R-HSA-3000423)
SUMO3-K65,K160,K490-PML [nucleoplasm]
(R-HSA-3000386)
SUMO1-K65,160,490-PML [nucleoplasm]
(R-HSA-3000440)
PML [nucleoplasm]
(R-HSA-1031706)
PML [cytosol]
(R-HSA-5624327)
0.524
4
UniProt:P12815 PDCD6
0.508
2
UniProt:Q03135 CAV1
5
CAV1 [early endosome membrane]
(R-HSA-5368451)
CAV1 [plasma membrane]
(R-HSA-534994)
CAV1 [lipid droplet]
(R-HSA-163510)
CAV1 [endocytic vesicle membrane]
(R-HSA-535009)
CAV1 [Golgi membrane]
(R-HSA-204504)
0.463
3
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