Reactome | FTH1 [cytosol]

FTH1 [cytosol]

Stable Identifier

R-HSA-434212

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ferritin heavy chain, FRIH_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - trans-Golgi Network Vesicle Budding (Homo sapiens)
    - Golgi Associated Vesicle Biogenesis (Homo sapiens)
      - Recruitment Of Cytoplasmic Proteins To Vesicles (Homo sapiens)
        
        Ferritin Complex [cytosol] (Homo sapiens)
        
        FTH1:FTL [cytosol] (Homo sapiens)
        
        FTH1 [cytosol] (Homo sapiens)
        
        Golgi-associated vesicle interacting proteins [cytosol] (Homo sapiens)
        
        Ferritin Complex [cytosol] (Homo sapiens)
        
        FTH1:FTL [cytosol] (Homo sapiens)
        
        FTH1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P02794 FTH1

Gene Names

FTH1, FTH, FTHL6, OK/SW-cl.84, PIG15

Chain

chain:1-183, initiator methionine:, chain:2-183

Reference Genes

BioGPS Gene:2495 FTH1

COSMIC (genes):FTH1 FTH1

CTD Gene:2495 FTH1

dbSNP Gene:2495 FTH1

ENSEMBL:ENSG00000167996 FTH1

ENSEMBL_homo_sapiens_GENE:ENSG00000167996.16 FTH1

HGNC:3976 FTH1

KEGG Gene (Homo sapiens):2495 FTH1

Monarch:2495 FTH1

NCBI Gene:2495 FTH1

OMIM:134770 FTH1

UCSC:P02794 FTH1

Reference Transcript

RefSeq:NM_002032.2 FTH1

Other Identifiers

11752577_at

11757633_x_at

200748_3p_s_at

200748_PM_s_at

200748_s_at

214211_PM_at

214211_at

2384397

2495

2545844

2545846

2590361

2590364

2629711

2850328

2956776

3142410

31697_s_at

3375649

3375650

3375651

3375652

3375654

3375656

3375657

3375663

3375664

3375665

3375666

33943_at

3505170

3994182

7948656

8170360

A_21_P0013796

A_24_P919330

GE63127

GE81103

GO:0002376

GO:0003824

GO:0004322

GO:0005506

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005764

GO:0005773

GO:0005829

GO:0006826

GO:0006879

GO:0006880

GO:0006955

GO:0008043

GO:0008198

GO:0008199

GO:0008285

GO:0016491

GO:0031410

GO:0042802

GO:0043226

GO:0044754

GO:0046872

GO:0048147

GO:0055065

GO:0070062

GO:0140313

GO:0140315

GO:1904724

GO:1904813

Hs.62954.5.A1_3p_x_at

ILMN_1683146

L20941_at

TC11001860.hg

TC11003179.hg

g4503794_3p_s_at

Participates

as a member of

FTH1:FTL [cytosol] (Homo sapiens)

Other forms of this molecule

FTH1 [ficolin-1-rich granule lumen]

FTH1 [tertiary granule lumen]

FTH1 [endocytic vesicle lumen]

FTH1 [extracellular region]

Inferred To

Fer2LCH [cytosol] (Drosophila melanogaster)

ftmt [cytosol] (Xenopus tropicalis)

Fer1HCH [cytosol] (Drosophila melanogaster)

Homologues of FTH1 [cytosol] (Caenorhabditis elegans)

Homologues of FTH1 [cytosol] (Canis familiaris)

Homologues of FTH1 [cytosol] (Drosophila melanogaster)

Homologues of FTH1 [cytosol] (Rattus norvegicus)

LOC119865338 [cytosol] (Canis familiaris)

fth1a [cytosol] (Danio rerio)

Fth1-ps5 [cytosol] (Rattus norvegicus)

FTH1 [cytosol] (Bos taurus)

FTH1 [cytosol] (Caenorhabditis elegans)

FTH1 [cytosol] (Canis familiaris)

FTH1 [cytosol] (Gallus gallus)

FTH1 [cytosol] (Mus musculus)

FTH1 [cytosol] (Rattus norvegicus)

FTH1 [cytosol] (Sus scrofa)

Fer3HCH [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_002023.2

OpenTargets

ENSG00000167996

HPA

ENSG00000167996-FTH1

GeneCards

P02794

Ensembl

ENSG00000167996, ENST00000273550, ENSP00000273550, ENSP00000484477, ENST00000620041

PRO

P02794

Pharos - Targets

P02794

Orphanet

17368

HMDB Protein

HMDBP08672

PDB

7JGL, 6B8F, 6H6T, 5N26, 6H6U, 6KE4, 6B8G, 8CPV, 8AAV, 2CN7, 7K3V, 8PP3, 5JKM, 6H5I, 8CPM, 4YKH, 7K3W, 3AJQ, 8CPW, 2CLU, 6J4A, 6WYF, 7JGQ, 5CMQ, 6GSR, 3ERZ, 8CPU, 4DYZ, 8PP2, 6Z9F, 8HHS, 8JAI, 4OYN, 6KE2, 7CK9, 8B7O, 6FTV, 7JGO, 2CN6, 5JKK, 5JKL, 7JGP, 3AJO, 7PF1, 2Z6M, 7V66, 6JPS, 7A6A, 7JGK, 2IU2, 6JOB, 3ES3, 8DHX, 6M54, 4DZ0, 5YI5, 7R5O, 5UP8, 7CK8, 6WYH, 8CPT, 8J9M, 6Z9E, 5UP9, 7KE5, 5GN8, 6J7G, 7JGN, 5VTD, 8A5N, 2CHI, 8A2M, 6Z6U, 6M52, 2FHA, 3AJP, 4DYX, 4DYY, 2CEI, 2CIH, 5CMR, 7ZG7, 5N27, 7A6B, 6WYG, 4Y08, 6IPO, 5GOU, 4ZJK, 6IPP, 7JGM, 7K26, 6IPQ, 7RRP, 5XB1, 8CPX, 5ZND, 7VD8, 8PP5, 8A2L, 1FHA, 7KE3, 6IPC, 8J9L, 8F49, 8CPS, 5UP7, 8DNP

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UER7 DAXX	13	monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX S138* [nucleoplasm] (R-HSA-9673081) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A36Qfs*108 [nucleoplasm] (R-HSA-9673105) DAXX [nucleoplasm] (R-HSA-3222068)	0.691	5
UniProt:Q92574 TSC1	2	TSC1 [plasma membrane] (R-HSA-165169) TSC1 [cytosol] (R-HSA-5672338)	0.635	3
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.601	4
UniProt:P02753 RBP4	3	RBP4 G75D [extracellular region] (R-HSA-2471928) RBP4 I41N [extracellular region] (R-HSA-2471954) RBP4(19-201) [extracellular region] (R-HSA-2453675)	0.527	2
UniProt:Q9Y337 KLK5	4	KLK5 [extracellular region] (R-HSA-8849629) proKLK5 [extracellular region] (R-HSA-8849836) KLK5 propeptide [extracellular region] (R-HSA-8849839) KLK5 [cytosol] (R-HSA-8934778)	0.527	2
UniProt:P07476 IVL	2	IVL [cornified envelope] (R-HSA-8847720) IVL [cytosol] (R-HSA-6810837)	0.527	2
UniProt:O60437 PPL	2	PPL [cytosol] (R-HSA-6810850) PPL [cornified envelope] (R-HSA-8847709)	0.527	2
UniProt:P22735 TGM1	3	TGM1 [cytosol] (R-HSA-6813756) TGM1 [cornified envelope] (R-HSA-8847706) TGM1 [plasma membrane] (R-HSA-6813757)	0.527	2
UniProt:P42357 HAL	1	HAL [cytosol] (R-HSA-70897)	0.527	2
UniProt:P20930 FLG	2	FLG(?-?) [cytosol] (R-HSA-6810859) FLG(1-4061) [cytosol] (R-HSA-8849818)	0.527	2
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.508	2

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