Reactome | CBX6 [nucleoplasm]

CBX6 [nucleoplasm]

Stable Identifier

R-HSA-3229071

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Chromobox protein homolog 6

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
        
        RUNX1 binds PRC1 complexes (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.4 [nucleoplasm] (Homo sapiens)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
        
        CBX6 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.4 [nucleoplasm] (Homo sapiens)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
        
        CBX6 [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - PTEN Regulation (Homo sapiens)
      - Regulation of PTEN gene transcription (Homo sapiens)
        
        MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Homo sapiens)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
        
        PRC1.4 [nucleoplasm] (Homo sapiens)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
        
        CBX6 [nucleoplasm] (Homo sapiens)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
        
        PRC1.4 [nucleoplasm] (Homo sapiens)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
        
        CBX6 [nucleoplasm] (Homo sapiens)
        
        PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
        
        PRC1.4 [nucleoplasm] (Homo sapiens)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
        
        CBX6 [nucleoplasm] (Homo sapiens)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
        
        PRC1.4 [nucleoplasm] (Homo sapiens)
        
        CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
        
        CBX6 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95503 CBX6

Gene Names

CBX6

Chain

chain:1-412

Reference Genes

BioGPS Gene:23466 CBX6

COSMIC - genes:CBX6 CBX6

CTD Gene:23466 CBX6

dbSNP Gene:23466 CBX6

ENSEMBL:ENSG00000183741 CBX6

HGNC:1556 CBX6

KEGG:hsa:23466 CBX6

Monarch:23466 CBX6

NCBI Gene:23466 CBX6

OMIM:617438 CBX6

UCSC:O95503 CBX6

Reference Transcript

Other Identifiers

11720081_a_at

11720082_at

16935195

202047_PM_s_at

202047_s_at

202048_PM_s_at

202048_s_at

23466

39561_at

3960931

3960932

3960933

3960934

3960935

3960936

3960937

3960938

3960939

3960940

3960941

3960942

3960943

3960944

3960945

3960946

3960947

3960948

3960949

3960950

3960951

3960952

3960953

8076176

A_24_P254437

A_24_P370372

A_33_P3270485

GE81906

GO:0000122

GO:0000785

GO:0000792

GO:0003682

GO:0003723

GO:0003727

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0006355

GO:0016604

GO:0031519

GO:0035102

HMNXSV003005540

HMNXSV003022144

HMNXSV003051214

Hs.107374.0.A1_3p_a_at

ILMN_1691930

PH_hs_0026686

TC22000799.hg

g10140848_3p_a_at

Participates

as a member of

CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)

Inferred To

Cbx6 [nucleoplasm] (Mus musculus)

Cbx6 [nucleoplasm] (Rattus norvegicus)

Pc [nucleoplasm] (Drosophila melanogaster)

CBX6 [nucleoplasm] (Bos taurus)

CBX6 [nucleoplasm] (Canis familiaris)

CBX6 [nucleoplasm] (Sus scrofa)

cbx6 [nucleoplasm] (Xenopus tropicalis)

Cross References

ENSEMBL

ENSG00000183741, ENST00000407418, ENSP00000384490

OpenTargets

ENSG00000183741

GeneCards

CBX6

HPA

ENSG00000183741-CBX6

PRO

O95503

Pharos - Targets

O95503

PDB

3GV6, 3I90

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35227 PCGF2	1	PCGF2 [nucleoplasm] (R-HSA-389115)	0.813	6
UniProt:P11686 SFTPC	9	pro-SFTPC P115L [endoplasmic reticulum membrane] (R-HSA-5688352) pro-SFTPC P30L [endoplasmic reticulum membrane] (R-HSA-5688365) pro-SFTPC [endoplasmic reticulum membrane] (R-HSA-5683842) pro-SFTPC [multivesicular body lumen] (R-HSA-5685298) SFTPC [extracellular region] (R-HSA-5683685) SFTPC [clathrin-coated endocytic vesicle] (R-HSA-5686342) SFTPC [lamellar body] (R-HSA-5683717) SFTPC(24-58) [multivesicular body lumen] (R-HSA-5685899) SFTPC(59-197) [multivesicular body lumen] (R-HSA-5685871)	0.527	3
UniProt:Q9Y6M1 IGF2BP2	1	IGF2BP2 [cytosol] (R-HSA-428302)	0.527	2
UniProt:Q8TBF4 ZCRB1	2	ZCRB1 [cytosol] (R-HSA-9682010) ZCRB1 [nucleoplasm] (R-HSA-6787853)	0.527	2
UniProt:O00425 IGF2BP3	1	IGF2BP3 [cytosol] (R-HSA-428313)	0.527	2
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.527	2
UniProt:Q9H6S0 YTHDC2	1	YTHDC2 [nucleoplasm] (R-HSA-9935827)	0.527	2
UniProt:Q9Y4W2 LAS1L	1	LAS1L [nucleoplasm] (R-HSA-6791521)	0.527	2
UniProt:Q13243 SRSF5	1	SRSF5 [nucleoplasm] (R-HSA-72028)	0.527	2
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.527	3
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.527	2
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [extracellular region] (R-HSA-9017791) YBX1 [nucleoplasm] (R-HSA-72041)	0.527	2
UniProt:P61247 RPS3A	2	RPS3A [cytosol] (R-HSA-72373) RPS3A [nucleoplasm] (R-HSA-6791182)	0.527	3