Reactome | GAS8 [cytosol]

GAS8 [cytosol]

Stable Identifier

R-HSA-5633057

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O95995 GAS8

Gene Names

GAS8, DRC4, GAS11

Chain

chain:1-478

Reference Genes

BioGPS Gene:2622 GAS8

COSMIC (genes):GAS8 GAS8

CTD Gene:2622 GAS8

dbSNP Gene:2622 GAS8

ENSEMBL:ENSG00000141013 GAS8

ENSEMBL_homo_sapiens_GENE:ENSG00000141013 GAS8

HGNC:4166 GAS8

KEGG Gene (Homo sapiens):2622 GAS8

Monarch:2622 GAS8

NCBI Gene:2622 GAS8

OMIM:605178 GAS8

UCSC:O95995 GAS8

Reference Transcript

Other Identifiers

0004480408

11747204_a_at

11754639_a_at

11754816_a_at

16822224

204921_at

2622

36479_at

3674665

3674668

3674669

3674670

3674673

3674676

3674677

3674680

3674682

3674684

3674685

3674686

41311

48238

7998103

A0A087WZT7

A_14_P133549

A_23_P206435

A_24_P279203

A_33_P3405921

AAC69518

AAC69519

AAI04786

AAI12122

AC133919

AF050068

AF050069

AF050070

AF050071

AF050072

AF050073

AF050074

AF050075

AF050076

AF050077

AF050078

AF050079

AK297857

AK315261

BAG37678

BAH12677

BC104785

BC112121

CCDS10992

CCDS67101

CH471184

EAW66659

EAW66661

ENSG00000141013

ENSP00000268699

ENSP00000440977

ENST00000268699

ENST00000536122

EntrezGene:2622

g4503916_3p_at

GAS8

GAS8-201

GAS8-202

GE81030

GO:0003351

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005794

GO:0005815

GO:0005856

GO:0005874

GO:0005929

GO:0005930

GO:0007010

GO:0007165

GO:0007368

GO:0007420

GO:0008017

GO:0008092

GO:0008150

GO:0008283

GO:0008285

GO:0015630

GO:0017137

GO:0019899

GO:0022607

GO:0030317

GO:0031514

GO:0034613

GO:0035082

GO:0036064

GO:0036126

GO:0040011

GO:0042995

GO:0043226

GO:0045880

GO:0048856

GO:0048870

GO:0060294

GO:0097729

GO:1903566

GO:1904526

H3BP65

H3BQT7

H3BUA7

HGNC:4166

HPA041311

HPA048238

ILMN_1783798

IPR025593

IPR039308

MIM:605178

MIM:616726

NM_001286209

NM_001481

NP_001273138

NP_001472

PF13851

PH_hs_0025228

TC16000711.hg

TC16001722.hg

uc002fqi.1

uc010vps.2

UPI0000070A4C

UPI0000EE7DD0

XM_005256304

XP_005256361

XP_024305996

This entity regulates

Positively

SMO translocates to the cilium

Inferred To

Homologues of GAS8 [cytosol] (Canis familiaris)

GAS8 [cytosol] (Bos taurus)

GAS8 [cytosol] (Canis familiaris)

GAS8 [cytosol] (Danio rerio)

GAS8 [cytosol] (Gallus gallus)

GAS8 [cytosol] (Mus musculus)

GAS8 [cytosol] (Rattus norvegicus)

GAS8 [cytosol] (Sus scrofa)

GAS8 [cytosol] (Taeniopygia guttata)

GAS8 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001472.1, NP_001273137.1, NP_001273134.1, NP_001273138.1, XP_005256361.1

OpenTargets

ENSG00000141013

GeneCards

O95995

PRO

O95995

Orphanet

23429

Interactors (110)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15041 AR6P1			0.488	2
UniProt:Q96MF2 STAC3			0.488	2
UniProt:Q15560 TCEA2			0.488	2
UniProt:Q8TD31-3 CCHCR1			0.488	2
UniProt:Q3KQV3 ZNF792	1	ZNF792 [nucleoplasm] (R-HSA-3110242)	0.488	2
UniProt:Q96HT8 MR1L1			0.488	2
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.488	2
UniProt:Q9NYW8 RBAK			0.488	2
UniProt:Q96GS4 BORC6			0.488	2
UniProt:P25791-3 LMO2			0.488	2
UniProt:Q86Z20 CC125			0.488	2
UniProt:Q15311 RALBP1	1	RALBP1 [cytosol] (R-HSA-195194)	0.488	2
UniProt:Q9UER7 DAXX	2	DAXX [nucleoplasm] (R-HSA-3222068) SUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.488	2
UniProt:Q9UBR4-2 LHX3			0.488	2
UniProt:Q13136 PPFIA1	1	PPFIA1 [cytosol] (R-HSA-383377)	0.488	2
UniProt:Q13895 BYSL	2	BYSL [cytosol] (R-HSA-6791518) BYSL [nucleoplasm] (R-HSA-6791526)	0.488	2
UniProt:Q7Z3Y8 KRT27	1	KRT27 [cytosol] (R-HSA-6809587)	0.488	2
UniProt:Q6NUQ1 RINT1	1	RINT1 [cytosol] (R-HSA-6810991)	0.488	2
UniProt:Q9NPF5 DMAP1	1	DMAP1 [nucleoplasm] (R-HSA-212166)	0.488	2
UniProt:O60504 SORBS3	1	SORBS3 [cytosol] (R-HSA-445805)	0.488	2
UniProt:O00444 PLK4	1	PLK4 [cytosol] (R-HSA-380286)	0.488	2
UniProt:Q7Z3I7 ZN572			0.488	2
UniProt:Q9BW66 CINP			0.488	2
UniProt:Q9GZV8 PRDM14	1	PRDM14 [nucleoplasm] (R-HSA-1112608)	0.488	2
UniProt:P53674 CRBB1			0.488	2
UniProt:Q9NSC5 HOMER3	1	HOMER3 [cytosol] (R-HSA-6794236)	0.488	2
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.488	2
UniProt:A8MQ03 CRTP1			0.488	2
UniProt:Q9BWG6 SCNM1			0.488	2
IntAct:EBI-11957986 HOMEZ			0.488	2
UniProt:O75031 HSF2B			0.488	2
UniProt:Q92622 RUBIC			0.488	2
UniProt:Q14847-2 LASP1			0.488	2
UniProt:P07992-3 ERCC1			0.488	2
UniProt:Q9BWT7 CAR10			0.488	2
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.488	2
UniProt:P02533 KRT14	1	KRT14 [cytosol] (R-HSA-446091)	0.488	2
UniProt:Q9HCK0 ZBT26			0.488	2
UniProt:P55040 GEM			0.488	2
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.488	2
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.488	2
UniProt:Q3SY00 T10IP			0.488	2
UniProt:P19012 KRT15	1	KRT15 [cytosol] (R-HSA-6809589)	0.488	2
UniProt:P15622-3 ZNF250			0.488	2
UniProt:B4DWU0 B4DWU0			0.488	2
UniProt:P25800 LMO1	1	LMO1 [nucleoplasm] (R-HSA-8956514)	0.488	2
UniProt:Q8IYE0 CC146			0.488	2
UniProt:Q9Y250 LZTS1			0.488	2
UniProt:Q3B820 F161A			0.488	2
UniProt:Q2TBE0 C19L2			0.488	2
UniProt:Q92841 DDX17	2	SUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104) DDX17 [nucleoplasm] (R-HSA-3900090)	0.488	2
UniProt:Q8TAE8 GADD45GIP1	1	GADD45GIP1 [mitochondrial matrix] (R-HSA-5368253)	0.488	2
UniProt:Q99633 PRP18			0.488	2
UniProt:P24592 IGFBP6	1	IGFBP6 [extracellular region] (R-HSA-381475)	0.488	2
UniProt:Q08426 EHHADH	2	EHHADH [cytosol] (R-HSA-9033147) EHHADH [peroxisomal matrix] (R-HSA-400155)	0.488	2
UniProt:Q96CN9 GCC1	1	GCC1 [cytosol] (R-HSA-6813877)	0.488	2
UniProt:Q6PI77 BHLH9			0.488	2
UniProt:Q9NZD8 SPG21			0.488	2
UniProt:Q9UJV3-2 MID2			0.488	2
UniProt:O75815 BCAR3			0.488	2
UniProt:Q9H257-2 CARD9			0.488	2
UniProt:P08779 KRT16	1	KRT16 [cytosol] (R-HSA-201581)	0.488	2
UniProt:Q16204 CCDC6			0.488	2
UniProt:Q8N3L3 TXLNB			0.488	2
UniProt:Q9UDV6 ZNF212	1	ZNF212 [nucleoplasm] (R-HSA-1027348)	0.488	2
UniProt:Q8N684-3 CPSF7			0.488	2
UniProt:Q8TDD2 SP7	1	SP7 [nucleoplasm] (R-HSA-8939843)	0.488	2
UniProt:O15060 ZBT39			0.488	2
UniProt:P12757 SKIL	1	SKIL [nucleoplasm] (R-HSA-2186596)	0.488	2
UniProt:Q9NVV9 THAP1			0.488	2
UniProt:Q9BU76 MMTAG2	3	MMTAG2 [extracellular region] (R-HSA-6806452) MMTAG2 [secretory granule lumen] (R-HSA-6801073) MMTAG2 [ficolin-1-rich granule lumen] (R-HSA-6801074)	0.488	2
UniProt:Q9NRI5-2 DISC1			0.488	2
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.488	2
UniProt:P21580 TNFAIP3	1	TNFAIP3 [cytosol] (R-HSA-688989)	0.488	2
UniProt:Q9UEG4 ZN629			0.488	2
UniProt:Q9Y2V7 COG6	2	COG6 [Golgi membrane] (R-HSA-2980958) COG6 [trans-Golgi network membrane] (R-HSA-6813872)	0.488	2
UniProt:O15217 GSTA4	1	GSTA4 [cytosol] (R-HSA-159204)	0.488	2
UniProt:Q4V328 GRAP1			0.488	4
UniProt:Q96MH2 HEXI2			0.488	2
UniProt:Q96JM7-2 L3MBTL3			0.488	2
UniProt:Q9UHB4 NDOR1	1	NDOR1 [cytosol] (R-HSA-2564776)	0.488	2
UniProt:Q96PV4 PNMA5			0.488	2
UniProt:Q01850 CDR2			0.488	2
UniProt:Q9BW85 YJU2			0.488	2
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.488	2
UniProt:Q6ZUT1 NKAP1			0.488	2
UniProt:Q8N9N8 EIF1A			0.488	2
UniProt:O15209 ZBT22			0.488	2
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.488	2
UniProt:Q8TC71 MIEAP			0.488	2
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.488	2
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.488	2
UniProt:Q969R5 L3MBTL2	2	SUMO2-K675,K700-L3MBTL2 [nucleoplasm] (R-HSA-6804480) L3MBTL2 [nucleoplasm] (R-HSA-6804477)	0.488	2
UniProt:P43897 TSFM	1	TSFM [mitochondrial matrix] (R-HSA-5389837)	0.488	2
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [cytosol] (R-HSA-191876) PRMT5 [nucleoplasm] (R-HSA-5205609)	0.488	2
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.488	2
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.488	2
UniProt:Q96M91 CFA53			0.488	2
UniProt:Q96CN4 EVI5L			0.488	2
IntAct:EBI-11953908 CBFA2T3			0.488	2
UniProt:Q96T60 PNKP	1	PNKP [nucleoplasm] (R-HSA-5649651)	0.488	2
UniProt:Q96MY7 F161B			0.488	2
UniProt:Q9BYV2 TRI54			0.488	2
UniProt:O15160 POLR1C	2	POLR1C [nucleoplasm] (R-HSA-63498) POLR1C [cytosol] (R-HSA-1964454)	0.488	2
UniProt:P51959 CCNG1	1	CCNG1 [nucleoplasm] (R-HSA-6792489)	0.488	2
UniProt:Q8WV44 TRIM41	1	TRIM41 [cytosol] (R-HSA-5688975)	0.488	2
UniProt:O00463 TRAF5			0.488	2
UniProt:P55081 MFAP1	1	MFAP1 [extracellular region] (R-HSA-2396419)	0.488	2
UniProt:Q5HYN5 CT451			0.488	2
UniProt:Q8N6Y0 USBP1			0.488	2