Reactome | SPEN [cytosol]

SPEN [cytosol]

Stable Identifier

R-HSA-9715142

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RHOBTB GTPase Cycle (Homo sapiens)
        
        RHOBTB1 GTPase cycle (Homo sapiens)
        
        RHOBTB1 binds interacting proteins at the endosome membrane (Homo sapiens)
        
        RHOBTB1 interacting proteins [cytosol] (Homo sapiens)
        
        SPEN [cytosol] (Homo sapiens)
        
        RHOBTB1:GTP:RHOBTB1 interacting proteins [endosome membrane] (Homo sapiens)
        
        RHOBTB1 interacting proteins [cytosol] (Homo sapiens)
        
        SPEN [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96T58 SPEN

Gene Names

SPEN, KIAA0929, MINT, SHARP

Chain

chain:1-3664

Reference Genes

BioGPS Gene:23013 SPEN

COSMIC (genes):SPEN SPEN

CTD Gene:23013 SPEN

dbSNP Gene:23013 SPEN

ENSEMBL:ENSG00000065526 SPEN

HGNC:17575 SPEN

Monarch:23013 SPEN

NCBI Gene:23013 SPEN

OMIM:613484 SPEN

UCSC:Q96T58 SPEN

Reference Transcript

RefSeq:NM_015001.2 SPEN

Other Identifiers

11743665_at

11743666_at

11758513_s_at

1556058_PM_s_at

1556058_s_at

1556059_PM_s_at

1556059_s_at

16659765

201996_PM_s_at

201996_s_at

201997_PM_s_at

201997_s_at

23013

2322094

2322095

2322097

2322104

2322105

2322108

2322109

2322110

2322111

2322112

2322120

2322122

2322124

2322125

2322126

2322127

2322128

2322132

2322133

2322134

2322135

2322136

2322137

2322138

2322139

2322140

2322141

2322142

2322143

2322144

2322145

2322146

2322147

2322148

2322149

2322150

2322151

2322152

2322153

2322154

2322155

2322156

2322157

2322162

2322164

2322166

2322167

2322169

32172_at

62241_at

73012_at

7898278

A_23_P12053

A_24_P170660

A_24_P345193

A_24_P353732

A_33_P3347417

GE81982

GO:0000122

GO:0003676

GO:0003677

GO:0003714

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0006325

GO:0006355

GO:0006357

GO:0007219

GO:0010558

GO:0017053

GO:0031047

GO:0031048

GO:0043226

GO:0043231

GO:0045892

GO:0050769

GO:0060090

GO:0060816

GO:0061629

GO:0070062

GO:0140110

HMNXSV003045949

Hs.184245.0.S1_3p_a_at

Hs2.433418.1.S1_3p_s_at

Hs2.433418.1.S2_3p_s_at

ILMN_1802611

PH_hs_0010856

TC01000198.hg

TC01004194.hg

g7657266_3p_a_at

p28370

Participates

as a candidate of

RHOBTB1 interacting proteins [cytosol] (Homo sapiens)

Inferred To

spen [cytosol] (Drosophila melanogaster)

spen [cytosol] (Xenopus tropicalis)

SPEN [cytosol] (Bos taurus)

SPEN [cytosol] (Canis familiaris)

SPEN [cytosol] (Dictyostelium discoideum)

SPEN [cytosol] (Gallus gallus)

Spen [cytosol] (Mus musculus)

Spen [cytosol] (Rattus norvegicus)

Cross References

ENSEMBL

ENST00000375759, ENSP00000364912

OpenTargets

ENSG00000065526

HPA

ENSG00000065526-SPEN

PRO

Q96T58

Pharos - Targets

Q96T58

GlyGen

Q96T58

PDB

2RT5, 7Z1K, 4P6Q, 1OW1

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q06330 RBPJ	1	RBPJ [nucleoplasm] (R-HSA-3008668)	0.688	3
UniProt:Q9Y618 NCOR2	2	NCOR2 [nucleoplasm] (R-HSA-442469) monoSUMO1-K672-NCOR2 [nucleoplasm] (R-HSA-3927904)	0.618	5
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.609	2
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.527	3