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INTS12 [nucleoplasm]
Stable Identifier
R-HSA-6807456
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Integrator complex subunit 12, INT12_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA polymerase II transcribes snRNA genes (Homo sapiens)
CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS12 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS12 [nucleoplasm] (Homo sapiens)
Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS12 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS12 [nucleoplasm] (Homo sapiens)
Integrator complex processes the 3' end of snRNA (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS12 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS12 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS12 [nucleoplasm] (Homo sapiens)
Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS12 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS12 [nucleoplasm] (Homo sapiens)
Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS12 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS12 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96CB8 INTS12
Gene Names
INTS12, PHF22, SBBI22
Chain
chain:1-462
Reference Genes
BioGPS Gene:57117 INTS12
COSMIC (genes):INTS12 INTS12
CTD Gene:57117 INTS12
dbSNP Gene:57117 INTS12
ENSEMBL:ENSG00000138785 INTS12
HGNC:25067 INTS12
KEGG:hsa:57117 INTS12
Monarch:57117 INTS12
NCBI Gene:57117 INTS12
OMIM:611355 INTS12
UCSC:Q96CB8 INTS12
Reference Transcript
RefSeq:NM_001142471.1 INTS12
RefSeq:NM_020395.3 INTS12
RefSeq:XM_005263148.4 INTS12
RefSeq:XM_011532143.2 INTS12
RefSeq:XM_011532145.2 INTS12
Other Identifiers
11717547_a_at
16978692
218616_PM_at
218616_at
2780657
2780658
2780659
2780660
2780661
2780662
2780663
2780665
2780666
2780670
2780671
2780672
2780673
2780678
2780679
2780680
2780681
2780684
2780685
2780686
2780687
2780688
2780689
2780690
2780691
2780711
45735_at
57117
8102162
A_23_P81087
GE56912
GO:0005515
GO:0005634
GO:0005654
GO:0006355
GO:0016073
GO:0016180
GO:0032039
GO:0034243
GO:0034472
GO:0043226
GO:0046872
HMNXSV003012295
HMNXSV003058415
ILMN_1725169
PH_hs_0020068
TC04001446.hg
g9966872_3p_at
Participates
as a component of
Integrator [nucleoplasm] (Homo sapiens)
Inferred To
ints12 [nucleoplasm]
(Danio rerio)
ints12 [nucleoplasm]
(Xenopus tropicalis)
INTS12 [nucleoplasm]
(Bos taurus)
INTS12 [nucleoplasm]
(Caenorhabditis elegans)
INTS12 [nucleoplasm]
(Canis familiaris)
INTS12 [nucleoplasm]
(Gallus gallus)
INTS12 [nucleoplasm]
(Sus scrofa)
Ints12 [nucleoplasm]
(Mus musculus)
Ints12 [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of INTS12 [nucleoplasm]
(Dictyostelium discoideum)
IntS12 [nucleoplasm]
(Drosophila melanogaster)
Cross References
ENSEMBL
ENST00000451321
,
ENSG00000138785
,
ENSP00000378221
,
ENSP00000340737
,
ENSP00000415433
,
ENST00000340139
,
ENST00000394735
OpenTargets
ENSG00000138785
GeneCards
INTS12
HPA
ENSG00000138785-INTS12
PRO
Q96CB8
Pharos - Targets
Q96CB8
GlyGen
Q96CB8
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P67775 PPP2CA
4
PPP2CA [cytosol]
(R-HSA-165971)
PPP2CA [nucleoplasm]
(R-HSA-165978)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
0.643
3
UniProt:P35414 APLNR
1
APLNR [plasma membrane]
(R-HSA-374259)
0.527
2
UniProt:Q14627 IL13RA2
1
IL13RA2 [extracellular region]
(R-HSA-449666)
0.527
2
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