Reactome | Ac-K302-ANKLE2 [endoplasmic reticulum membrane]

Ac-K302-ANKLE2 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-9667946

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Ac-K302-LEM4

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q86XL3 ANKLE2

Gene Names

ANKLE2, KIAA0692, LEM4

Chain

chain:1-938

Reference Genes

BioGPS Gene:23141 ANKLE2

COSMIC (genes):ANKLE2 ANKLE2

CTD Gene:23141 ANKLE2

dbSNP Gene:23141 ANKLE2

ENSEMBL:ENSG00000176915 ANKLE2

ENSEMBL_homo_sapiens_GENE:ENSG00000176915.15 ANKLE2

HGNC:29101 ANKLE2

KEGG Gene (Homo sapiens):23141 ANKLE2

Monarch:23141 ANKLE2

NCBI Gene:23141 ANKLE2

OMIM:616062 ANKLE2

UCSC:Q86XL3 ANKLE2

Reference Transcript

Other Identifiers

11719204_at

11719205_at

11719206_s_at

11749281_a_at

16772702

16772704

212200_PM_at

212200_at

212201_PM_at

212201_at

23141

3479301

3479303

3479304

3479305

3479306

3479308

3479309

3479310

3479311

3479312

3479313

3479314

3479315

3479316

3479317

3479318

3479320

3479321

3479324

3479328

3479338

3479340

3479342

3479345

3479346

3479350

3479351

3479352

39519_at

7967792

7967794

A_23_P10858

A_33_P3329784

GE53394

GO:0000278

GO:0005515

GO:0005783

GO:0005789

GO:0007049

GO:0007084

GO:0007417

GO:0012501

GO:0016020

GO:0019888

GO:0035307

GO:0036211

GO:0042326

GO:0043066

GO:0043226

GO:0043229

GO:0048856

GO:0050790

GO:0051301

GO:0051721

GO:0061024

GO:0098772

GO:0140014

HMNXSV003011563

HMNXSV003018045

HMNXSV003025830

HMNXSV003045573

Hs.100729.0.A1_3p_at

Hs.100729.0.A2_3p_at

ILMN_1677979

ILMN_1772663

PH_hs_0027015

TC12002154.hg

TC12002155.hg

Participates

as an input of

ANKLE2 is deacetylated by SIRT2 (Homo sapiens)

Other forms of this molecule

ANKLE2 [endoplasmic reticulum membrane]

Inferred To

ANKLE2 [endoplasmic reticulum membrane] (Bos taurus)

ANKLE2 [endoplasmic reticulum membrane] (Canis familiaris)

ANKLE2 [endoplasmic reticulum membrane] (Sus scrofa)

Ac-K302-ANKLE2 [endoplasmic reticulum membrane] (Gallus gallus)

lem-4 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

Ankle2 [endoplasmic reticulum membrane] (Drosophila melanogaster)

Ankle2 [endoplasmic reticulum membrane] (Mus musculus)

Ankle2 [endoplasmic reticulum membrane] (Rattus norvegicus)

ankle2 [endoplasmic reticulum membrane] (Danio rerio)

ankle2 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Modified Residues

Name

N6-acetyl-L-lysine at 302

Coordinate

302

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Cross References

RefSeq

XP_011533089.1, NP_055929.1, XP_011533090.1

OpenTargets

ENSG00000176915

GeneCards

Q86XL3

HPA

ENSG00000176915-ANKLE2

Ensembl

ENST00000542657, ENSP00000437807, ENST00000357997, ENSP00000438551, ENSG00000176915, ENST00000542282, ENSP00000350686

PRO

Q86XL3

Pharos - Targets

Q86XL3

Orphanet

23518

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P30153 PPP2R1A	2	PPP2R1A [nucleoplasm] (R-HSA-165968) PPP2R1A [cytosol] (R-HSA-165982)	0.807	7
UniProt:P62714 PPP2CB	4	MeL-PPP2CB [nucleoplasm] (R-HSA-8857799) p-Y307-PPP2CB [cytosol] (R-HSA-8857935) PPP2CB [nucleoplasm] (R-HSA-165991) PPP2CB [cytosol] (R-HSA-165987)	0.725	5
UniProt:P67775 PPP2CA	4	MeL-PPP2CA [nucleoplasm] (R-HSA-8857791) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) PPP2CA [nucleoplasm] (R-HSA-165978) PPP2CA [cytosol] (R-HSA-165971)	0.643	3
UniProt:Q19848	3	VRK2 [mitochondrial outer membrane] (R-CEL-9715102) VRK1 [cytosol] (R-CEL-2995381) VRK2-2 [cytosol] (R-CEL-2995378)	0.558	2
UniProt:P22460 KCNA5	1	KCNA5 [plasma membrane] (R-HSA-977472)	0.527	2
UniProt:Q92990 GLMN	1	GLMN [cytosol] (R-HSA-8951779)	0.527	2
UniProt:Q16281 CNGA3			0.527	2
UniProt:Q99469 STAC			0.527	2
UniProt:Q9Y487 ATP6V0A2	2	ATP6V0A2 [phagocytic vesicle membrane] (R-HSA-1222546) ATP6V0A2 [endosome membrane] (R-HSA-912595)	0.527	2
UniProt:Q9H3K2 GHITM			0.527	3
UniProt:P24394 IL4R	2	IL4R [plasma membrane] (R-HSA-449670) p-Y-IL4R [plasma membrane] (R-HSA-6786087)	0.527	2

Cite Us!