Reactome | VWA9 [nucleoplasm]

VWA9 [nucleoplasm]

Stable Identifier

R-HSA-6807412

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

von Willebrand factor A domain-containing protein 9, VWA9_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA polymerase II transcribes snRNA genes (Homo sapiens)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        VWA9 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        VWA9 [nucleoplasm] (Homo sapiens)
    - Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        VWA9 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        VWA9 [nucleoplasm] (Homo sapiens)
    - Integrator complex processes the 3' end of snRNA (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        VWA9 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        VWA9 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        VWA9 [nucleoplasm] (Homo sapiens)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        VWA9 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        VWA9 [nucleoplasm] (Homo sapiens)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        VWA9 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        VWA9 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96SY0 INTS14

Gene Names

VWA9, C15orf44, INTS14

Chain

chain:1-518

Reference Genes

BioGPS Gene:81556 VWA9

CTD Gene:81556 VWA9

dbSNP Gene:81556 VWA9

ENSEMBL:ENSG00000138614.16 INTS14

HGNC:25372 VWA9

KEGG Gene (Homo sapiens):81556 VWA9

Monarch:81556 VWA9

NCBI Gene:81556 VWA9

UCSC:Q96SY0 VWA9

Reference Transcript

Other Identifiers

0004670139

11716190_a_at

11716191_at

11747587_a_at

16810828

221265_PM_s_at

221265_s_at

3629762

3629763

3629764

3629765

3629766

3629769

3629771

3629773

3629774

3629775

3629776

3629779

3629780

3629781

3629782

3629783

3629785

3629786

3629787

3629794

3629796

3629798

57207_at

7989834

81556

A_23_P37475

A_33_P3244921

GE83179

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0006351

GO:0006355

GO:0016073

GO:0016180

GO:0032039

GO:0032991

GO:0034243

GO:0034472

GO:0043226

HMNXSV003054597

ILMN_1724016

ILMN_1771326

ILMN_2268026

PH_hs_0000674

TC15001570.hg

TC15002583.hg

g13540585_3p_s_at

Participates

as a component of

Integrator [nucleoplasm] (Homo sapiens)

Inferred To

Ints14 [nucleoplasm] (Mus musculus)

Ints14 [nucleoplasm] (Rattus norvegicus)

vwa9 [nucleoplasm] (Danio rerio)

IntS14 [nucleoplasm] (Drosophila melanogaster)

ints14 [nucleoplasm] (Xenopus tropicalis)

Ghost homologue of VWA9 [nucleoplasm] (Caenorhabditis elegans)

INTS14 [nucleoplasm] (Bos taurus)

INTS14 [nucleoplasm] (Gallus gallus)

INTS14 [nucleoplasm] (Sus scrofa)

VWA9 [nucleoplasm] (Canis familiaris)

VWA9 [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001193987.1, XP_006720774.1, XP_006720772.1, XP_016878133.1, NP_001129515.1, NP_001193988.1, XP_011520403.1

HPA

ENSG00000138614-INTS14

GeneCards

Q96SY0

Ensembl

ENST00000313182, ENSG00000138614, ENSP00000408429, ENST00000420799, ENSP00000402898, ENST00000652388, ENSP00000498715, ENST00000431261, ENSP00000326379

PRO

Q96SY0

Pharos - Targets

Q96SY0

PDB

6SN1