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PPP2R1B [cytosol]
Stable Identifier
R-HSA-165980
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PP2A-subunit A beta isoform
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Mad1 binds kinetochore (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 recruits NUDC to mitotic spindle (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Kinetochore assembly (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Homo sapiens)
PDE4D5 in p-S26-ANXA2:PP2A:PDE4D5:ITGA5:ITGB1:fibronectin hydrolyzes cAMP to yield AMP (Homo sapiens)
p-S26-ANXA2:PP2A:PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
PP2A (PPP2CA:PPP2R2A:PPP2R1A,B) [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
PP2A dephosphorylates serine-127 of YAP1 (Homo sapiens)
p-S26-ANXA2:PP2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
PP2A (PPP2CA:PPP2R2A:PPP2R1A,B) [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
PP2A dephosphorylates serine-715 of PDE4D5 in p-S715-PDE4D5:integrin alpha5:integrin beta1:fibronectin (Homo sapiens)
p-S26-ANXA2:PP2A:PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
PP2A (PPP2CA:PPP2R2A:PPP2R1A,B) [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
p-S26-ANXA2:PP2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
PP2A (PPP2CA:PPP2R2A:PPP2R1A,B) [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
PPP2CA and PPP2R1A,B bind PPP2R2A in p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
p-S26-ANXA2:PP2A:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin [plasma membrane] (Homo sapiens)
PP2A (PPP2CA:PPP2R2A:PPP2R1A,B) [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by WNT in cancer (Homo sapiens)
Signaling by AMER1 mutants (Homo sapiens)
Truncations of AMER1 destabilize the destruction complex (Homo sapiens)
Truncated AMER1 mutants destabilize the destruction complex (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Signaling by APC mutants (Homo sapiens)
APC truncation mutants have impaired AXIN binding (Homo sapiens)
APC truncation mutants have impaired AXIN binding (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Signaling by AXIN mutants (Homo sapiens)
AXIN missense mutants destabilize the destruction complex (Homo sapiens)
AXIN mutants destabilize the destruction complex (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Signaling by CTNNB1 phospho-site mutants (Homo sapiens)
CTNNB1 S33 mutants aren't phosphorylated (Homo sapiens)
CTNNB1 S33 mutants aren't phosphorylated by GSK3beta (Homo sapiens)
pS37,T41,S45-CTNNB1 S33 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
CTNNB1 S37 mutants aren't phosphorylated (Homo sapiens)
CTNNB1 S37 mutants aren't phosphorylated by GSK3beta (Homo sapiens)
pT41,S45-CTNNB1 S37 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
CTNNB1 S45 mutants aren't phosphorylated (Homo sapiens)
CTNNB1 S45 mutants aren't phosphorylated by CK1alpha (Homo sapiens)
CTNNB1 S45 mutants:AXIN:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
CTNNB1 T41 mutants aren't phosphorylated (Homo sapiens)
CTNNB1 T41 mutants aren't phosphorylated by GSK3beta (Homo sapiens)
pS45-CTNNB1 T41 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Signaling by GSK3beta mutants (Homo sapiens)
Misspliced GSK3beta mutants stabilize beta-catenin levels (Homo sapiens)
pS45-beta-catenin:p-Axin:GSK3 del304-316:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3 del304-316:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Platelet sensitization by LDL (Homo sapiens)
PECAM-1 binds PP2A (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
p-PECAM:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
CTLA4 inhibitory signaling (Homo sapiens)
CTLA-4 binds B7-1/B7-2 (Homo sapiens)
CTLA4 dimer:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
CTLA4 dimer:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Dephosphorylation of AKT by PP2A (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
PP2A binds CTLA4 dimer (Homo sapiens)
CTLA4 dimer:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Phosphorylation of CTLA-4 (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
CTLA4 dimer:PP2A [plasma membrane] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
PKR-mediated signaling (Homo sapiens)
p-PKR dimer phosphorylates PPP2R5A (Homo sapiens)
Activated PPP2R5A-specific PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
PPP2R5A-specific PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Activation of PP2A by Xylulose-5-phosphate (Homo sapiens)
Inactive PP2A-ABdeltaC complex [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
PP2A-ABdeltaC complex [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
PP2A-mediated dephosphorylation of key metabolic factors (Homo sapiens)
Dephosphorylation of pChREBP (Ser 196) by PP2A (Homo sapiens)
PP2A-ABdeltaC complex [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Dephosphorylation of phosphoPFKFB1 by PP2A complex (Homo sapiens)
PP2A-ABdeltaC complex [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glucose metabolism (Homo sapiens)
Glycolysis (Homo sapiens)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Homo sapiens)
Dephosphorylation of phosphoPFKFB1 by PP2A complex (Homo sapiens)
PP2A-ABdeltaC complex [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Homo sapiens)
PP2A-B56-beta,gamma [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
IER3 recruits MAPKs to PP2A-B56-beta,gamma (Homo sapiens)
PP2A-B56-beta,gamma [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Homo sapiens)
PP2A-B56-beta,gamma [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
p-Y307-PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
MAPKs phosphorylate PP2A (Homo sapiens)
PP2A-A:PP2A-C [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Homo sapiens)
PP2A-B56-beta,gamma [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
PP2A dephosphorylates RAF1 (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
RAF activation (Homo sapiens)
PP2A dephosphorylates KSR1 (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
PP2A dephosphorylates inactive RAFs (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
DARPP-32 events (Homo sapiens)
DARPP-32 is dephosphorylated on Thr75 by PP2A (Homo sapiens)
PP2A-ABdeltaC complex [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Degradation of beta-catenin by the destruction complex (Homo sapiens)
AXIN is phosphorylated in the destruction complex (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Assembly of the destruction complex (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Homo sapiens)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Association of beta-catenin with the destruction complex (Homo sapiens)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Beta-catenin phosphorylation cascade (Homo sapiens)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Homo sapiens)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Homo sapiens)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Homo sapiens)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Homo sapiens)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Degradation of ubiquitinated beta catenin by the proteasome (Homo sapiens)
p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Homo sapiens)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Homo sapiens)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Homo sapiens)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
Phosphorylation of APC component of the destruction complex (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Homo sapiens)
Beta-catenin is released from the destruction complex (Homo sapiens)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex (Homo sapiens)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
PP2A [cytosol] (Homo sapiens)
PP2A-subunit A [cytosol] (Homo sapiens)
PPP2R1B [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30154 PPP2R1B
Gene Names
PPP2R1B
Chain
initiator methionine:, chain:2-601
Reference Genes
BioGPS Gene:5519 PPP2R1B
COSMIC (genes):PPP2R1B PPP2R1B
CTD Gene:5519 PPP2R1B
dbSNP Gene:5519 PPP2R1B
ENSEMBL:ENSG00000137713 PPP2R1B
ENSEMBL_homo_sapiens_GENE:ENSG00000137713.16 PPP2R1B
HGNC:9303 PPP2R1B
KEGG Gene (Homo sapiens):5519 PPP2R1B
Monarch:5519 PPP2R1B
NCBI Gene:5519 PPP2R1B
OMIM:603113 PPP2R1B
UCSC:P30154 PPP2R1B
Reference Transcript
RefSeq:NM_001177562.1 PPP2R1B
RefSeq:NM_002716.4 PPP2R1B
RefSeq:NM_001177563.1 PPP2R1B
RefSeq:NM_181700.1 PPP2R1B
RefSeq:NM_181699.2 PPP2R1B
Other Identifiers
1093_at
1094_g_at
11731881_a_at
11733784_at
11733785_at
11747147_a_at
16744289
202883_PM_s_at
202883_s_at
202884_PM_s_at
202884_s_at
202885_PM_s_at
202885_s_at
202886_PM_s_at
202886_s_at
222351_PM_at
222351_at
3391030
3391031
3391037
3391038
3391039
3391040
3391041
3391042
3391043
3391046
3391048
3391049
3391052
3391055
3391056
3391057
3391059
3391060
3391063
3391066
3391067
3391069
3391070
3391071
3391072
41429_at
53816_i_at
54307_r_at
5519
56320_at
65331_at
65332_g_at
72441_at
7951614
A_23_P52793
A_24_P107291
A_24_P98762
GE80019
GO:0000159
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0012501
GO:0019888
GO:0023052
GO:0043226
GO:0045121
GO:0048856
GO:0060561
GO:0070062
GO:0098772
GO:2001241
HMNXSV003022219
HMNXSV003049074
Hs.108705.0.S3_3p_a_at
Hs.168737.0.A1_3p_at
ILMN_1704656
ILMN_1709247
ILMN_1779841
M65254_at
PH_hs_0025221
TC11002284.hg
g11386166_3p_a_at
g11386166_3p_s_at
g11692008_3p_a_at
g189429_3p_a_at
Participates
as a candidate of
PP2A-subunit A [cytosol] (Homo sapiens)
Other forms of this molecule
PPP2R1B [nucleoplasm]
Inferred To
PPP2R1B [cytosol]
(Bos taurus)
PPP2R1B [cytosol]
(Canis familiaris)
PPP2R1B [cytosol]
(Sus scrofa)
Ppp2r1b [cytosol]
(Mus musculus)
Ppp2r1b [cytosol]
(Rattus norvegicus)
paa-1 [cytosol]
(Caenorhabditis elegans)
paa1 [cytosol]
(Schizosaccharomyces pombe)
TPD3 [cytosol]
(Saccharomyces cerevisiae)
Pp2A-29B [cytosol]
(Drosophila melanogaster)
ppp2r1bb [cytosol]
(Danio rerio)
pppA [cytosol]
(Dictyostelium discoideum)
ppp2r1b [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_859051.1
,
NP_859050.1
,
NP_001171033.1
,
NP_001171034.1
,
NP_002707.3
OpenTargets
ENSG00000137713
HPA
ENSG00000137713-PPP2R1B
GeneCards
P30154
Ensembl
ENSP00000410671
,
ENST00000311129
,
ENSP00000437193
,
ENST00000426998
,
ENST00000341980
,
ENST00000527614
,
ENST00000393055
,
ENSP00000311344
,
ENSP00000343317
,
ENSP00000376775
,
ENSG00000137713
PRO
P30154
Pharos - Targets
P30154
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P67775 PPP2CA
4
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
PPP2CA [nucleoplasm]
(R-HSA-165978)
PPP2CA [cytosol]
(R-HSA-165971)
0.919
9
UniProt:P63151 PPP2R2A
2
PPP2R2A [nucleoplasm]
(R-HSA-1564978)
PPP2R2A [cytosol]
(R-HSA-377253)
0.727
5
UniProt:O43815 STRN
5
STRN [cytosol]
(R-HSA-9037081)
STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673902)
p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673908)
STRN(1-137)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9700485)
STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9700467)
0.725
5
UniProt:Q9Y6E0 STK24
4
STK24(1-313) [nucleoplasm]
(R-HSA-351944)
STK24(314-443) [cytosol]
(R-HSA-351898)
STK24(1-313) [cytosol]
(R-HSA-351892)
STK24 [cytosol]
(R-HSA-351829)
0.643
3
UniProt:O08722 Unc5b
1
Unc5b [plasma membrane]
(R-RNO-421655)
0.616
4
UniProt:Q9BRV8 SIKE1
1
SIKE1 [cytosol]
(R-HSA-916828)
0.527
2
UniProt:O08785 Clock
2
p-S-Clock [nucleoplasm]
(R-MMU-508670)
Clock [cytosol]
(R-MMU-508720)
0.508
2
UniProt:P11233 RALA
2
RALA [cytosol]
(R-HSA-170988)
GGC-RALA [cytoplasmic vesicle membrane]
(R-HSA-1458479)
0.499
6
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