Reactome | INTS4 [nucleoplasm]

INTS4 [nucleoplasm]

Stable Identifier

R-HSA-6807462

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Integrator complex subunit 4, INT4_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA polymerase II transcribes snRNA genes (Homo sapiens)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS4 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS4 [nucleoplasm] (Homo sapiens)
    - Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        INTS4 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS4 [nucleoplasm] (Homo sapiens)
    - Integrator complex processes the 3' end of snRNA (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        INTS4 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS4 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS4 [nucleoplasm] (Homo sapiens)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS4 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS4 [nucleoplasm] (Homo sapiens)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        INTS4 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96HW7 INTS4

Gene Names

INTS4, MSTP093

Chain

chain:1-963

Reference Genes

BioGPS Gene:92105 INTS4

COSMIC (genes):INTS4 INTS4

CTD Gene:92105 INTS4

dbSNP Gene:92105 INTS4

ENSEMBL:ENSG00000149262 INTS4

ENSEMBL_homo_sapiens_GENE:ENSG00000149262.19 INTS4

HGNC:25048 INTS4

KEGG Gene (Homo sapiens):92105 INTS4

Monarch:92105 INTS4

NCBI Gene:92105 INTS4

OMIM:611348 INTS4

UCSC:Q96HW7 INTS4

Reference Transcript

RefSeq:NM_033547.3 INTS4

Other Identifiers

11745566_a_at

11752935_s_at

11761466_at

1553670_PM_at

1553670_at

16742556

17124538

17124544

17124550

225169_PM_at

225169_at

3004944

3004945

3004946

3004948

3004949

3004950

3004951

3004952

3004953

3004954

3004956

3004958

3004959

3005008

3005009

3005011

3005013

3005014

3005016

3005017

3005018

3005019

3005020

3005021

3005024

3005025

3005026

3005030

3005034

3005146

3005148

3053586

3053588

3053589

3053590

3383080

3383082

3383083

3383084

3383085

3383089

3383090

3383091

3383093

3383094

3383095

3383096

3383097

3383099

3383102

3383103

3383104

3383105

3383107

3383108

3383109

3383110

3383112

3383113

3383114

3383115

3383116

3383118

3383122

3383123

3383124

3383127

3383128

3383129

36756_at

53854_at

7950628

8133074

8133095

92105

A_21_P0013228

A_21_P0013386

A_23_P203737

A_32_P120638

GE87763

GE87764

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0006351

GO:0006355

GO:0016073

GO:0016180

GO:0032039

GO:0034243

GO:0043226

HMNXSV003005437

HMNXSV003006016

HMNXSV003011627

HMNXSV003015872

Hs.14632.0.S1_3p_at

Hs2.14632.1.S1_3p_at

ILMN_1653738

ILMN_1660844

TC07000392.hg

TC11002131.hg

X61177_at

Participates

as a component of

Integrator [nucleoplasm] (Homo sapiens)

Inferred To

INTS4 [nucleoplasm] (Bos taurus)

INTS4 [nucleoplasm] (Canis familiaris)

INTS4 [nucleoplasm] (Gallus gallus)

INTS4 [nucleoplasm] (Sus scrofa)

ints4 [nucleoplasm] (Dictyostelium discoideum)

ints4 [nucleoplasm] (Xenopus tropicalis)

ints-4 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of INTS4 [nucleoplasm] (Danio rerio)

Ints4 [nucleoplasm] (Mus musculus)

Ints4 [nucleoplasm] (Rattus norvegicus)

IntS4 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_291025.3

OpenTargets

ENSG00000149262

GeneCards

Q96HW7

HPA

ENSG00000149262-INTS4

Ensembl

ENST00000534064, ENSP00000511691, ENST00000529807, ENSP00000433644, ENST00000525931, ENST00000695100, ENSG00000149262, ENSP00000511688, ENSP00000434466

PRO

Q96HW7

Pharos - Targets

Q96HW7

PDB

7BFQ, 7BFP, 7CUN, 7YCX, 7PKS

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.666	4
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.643	3