Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
INTS5 [nucleoplasm]
Stable Identifier
R-HSA-6807418
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Integrator complex subunit 5, INT5_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA polymerase II transcribes snRNA genes (Homo sapiens)
CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS5 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS5 [nucleoplasm] (Homo sapiens)
Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS5 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS5 [nucleoplasm] (Homo sapiens)
Integrator complex processes the 3' end of snRNA (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS5 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS5 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS5 [nucleoplasm] (Homo sapiens)
Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS5 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS5 [nucleoplasm] (Homo sapiens)
Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS5 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS5 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6P9B9 INTS5
Gene Names
INTS5, KIAA1698
Chain
initiator methionine:, chain:2-1019
Reference Genes
BioGPS Gene:80789 INTS5
COSMIC (genes):INTS5 INTS5
CTD Gene:80789 INTS5
dbSNP Gene:80789 INTS5
ENSEMBL:ENSG00000185085 INTS5
HGNC:29352 INTS5
KEGG:hsa:80789 INTS5
Monarch:80789 INTS5
NCBI Gene:80789 INTS5
OMIM:611349 INTS5
UCSC:Q6P9B9 INTS5
Reference Transcript
RefSeq:NM_030628.1 INTS5
Other Identifiers
11722084_at
16739432
221818_PM_at
221818_at
3375991
3375992
3375993
3375994
3375995
3375997
3375998
53968_PM_at
53968_at
7948772
80789
82765_at
A_23_P13338
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006355
GO:0016020
GO:0016073
GO:0016180
GO:0031965
GO:0032039
GO:0034243
GO:0034472
GO:0043226
HMNXSV003019789
Hs.6259.0.S1_3p_s_at
ILMN_1796968
PH_hs_0026368
TC11003485.hg
Participates
as a component of
Integrator [nucleoplasm] (Homo sapiens)
Inferred To
Ghost homologue of INTS5 [nucleoplasm]
(Danio rerio)
Ghost homologue of INTS5 [nucleoplasm]
(Gallus gallus)
Ghost homologue of INTS5 [nucleoplasm]
(Xenopus tropicalis)
Ints5 [nucleoplasm]
(Mus musculus)
Ints5 [nucleoplasm]
(Rattus norvegicus)
omd [nucleoplasm]
(Drosophila melanogaster)
INTS5 [nucleoplasm]
(Bos taurus)
INTS5 [nucleoplasm]
(Canis familiaris)
INTS5 [nucleoplasm]
(Dictyostelium discoideum)
INTS5 [nucleoplasm]
(Sus scrofa)
ints-5 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
ENSEMBL
ENST00000330574
,
ENSP00000327889
OpenTargets
ENSG00000185085
HPA
ENSG00000185085-INTS5
PRO
Q6P9B9
Pharos - Targets
Q6P9B9
PDB
8RC4
,
7CUN
,
7PKS
,
9EOF
,
8RBZ
,
8RBX
,
9EP4
,
7YCX
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01375 TNF
5
TNF(1-233) [plasma membrane]
(R-HSA-66220)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(52-76) [extracellular region]
(R-HSA-8863375)
0.527
2
UniProt:P67775 PPP2CA
4
PPP2CA [cytosol]
(R-HSA-165971)
PPP2CA [nucleoplasm]
(R-HSA-165978)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
0.527
2
UniProt:P08173 CHRM4
1
CHRM4 [plasma membrane]
(R-HSA-390693)
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text