Reactome | INTS5 [nucleoplasm]

INTS5 [nucleoplasm]

Stable Identifier

R-HSA-6807418

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Integrator complex subunit 5, INT5_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA polymerase II transcribes snRNA genes (Homo sapiens)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS5 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS5 [nucleoplasm] (Homo sapiens)
    - Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        INTS5 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS5 [nucleoplasm] (Homo sapiens)
    - Integrator complex processes the 3' end of snRNA (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        INTS5 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS5 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS5 [nucleoplasm] (Homo sapiens)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS5 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS5 [nucleoplasm] (Homo sapiens)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        INTS5 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS5 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q6P9B9 INTS5

Gene Names

INTS5, KIAA1698

Chain

initiator methionine:, chain:2-1019

Reference Genes

BioGPS Gene:80789 INTS5

COSMIC (genes):INTS5 INTS5

CTD Gene:80789 INTS5

dbSNP Gene:80789 INTS5

ENSEMBL:ENSG00000185085 INTS5

ENSEMBL_homo_sapiens_GENE:ENSG00000185085.2 INTS5

HGNC:29352 INTS5

KEGG Gene (Homo sapiens):80789 INTS5

Monarch:80789 INTS5

NCBI Gene:80789 INTS5

OMIM:611349 INTS5

UCSC:Q6P9B9 INTS5

Reference Transcript

RefSeq:NM_030628.1 INTS5

Other Identifiers

11722084_at

16739432

221818_PM_at

221818_at

3375991

3375992

3375993

3375994

3375995

3375997

3375998

53968_PM_at

53968_at

7948772

80789

82765_at

A_23_P13338

GO:0005515

GO:0005634

GO:0005635

GO:0005654

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0016020

GO:0016073

GO:0016180

GO:0031965

GO:0032039

GO:0034243

GO:0034472

GO:0043226

HMNXSV003019789

Hs.6259.0.S1_3p_s_at

ILMN_1796968

PH_hs_0026368

TC11003485.hg

Participates

as a component of

Integrator [nucleoplasm] (Homo sapiens)

Inferred To

Ghost homologue of INTS5 [nucleoplasm] (Danio rerio)

Ghost homologue of INTS5 [nucleoplasm] (Gallus gallus)

Ghost homologue of INTS5 [nucleoplasm] (Xenopus tropicalis)

Ints5 [nucleoplasm] (Mus musculus)

Ints5 [nucleoplasm] (Rattus norvegicus)

omd [nucleoplasm] (Drosophila melanogaster)

INTS5 [nucleoplasm] (Bos taurus)

INTS5 [nucleoplasm] (Canis familiaris)

INTS5 [nucleoplasm] (Dictyostelium discoideum)

INTS5 [nucleoplasm] (Sus scrofa)

ints-5 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_085131.1

OpenTargets

ENSG00000185085

GeneCards

Q6P9B9

HPA

ENSG00000185085-INTS5

Ensembl

ENST00000330574, ENSP00000327889, ENSG00000185085

PRO

Q6P9B9

Pharos - Targets

Q6P9B9

PDB

7PKS, 7YCX, 7CUN