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INTS2 [nucleoplasm]
Stable Identifier
R-HSA-6807448
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Integrator complex subunit 2, INT2_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA polymerase II transcribes snRNA genes (Homo sapiens)
CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS2 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS2 [nucleoplasm] (Homo sapiens)
Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS2 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS2 [nucleoplasm] (Homo sapiens)
Integrator complex processes the 3' end of snRNA (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS2 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS2 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS2 [nucleoplasm] (Homo sapiens)
Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS2 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS2 [nucleoplasm] (Homo sapiens)
Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS2 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H0H0 INTS2
Gene Names
INTS2, KIAA1287
Chain
chain:1-1204
Reference Genes
BioGPS Gene:57508 INTS2
COSMIC (genes):INTS2 INTS2
CTD Gene:57508 INTS2
dbSNP Gene:57508 INTS2
ENSEMBL:ENSG00000108506 INTS2
HGNC:29241 INTS2
KEGG:hsa:57508 INTS2
Monarch:57508 INTS2
NCBI Gene:57508 INTS2
OMIM:611346 INTS2
UCSC:Q9H0H0 INTS2
Reference Transcript
RefSeq:NM_020748.2 INTS2
RefSeq:NM_001330417.1 INTS2
Other Identifiers
11733457_at
11733458_s_at
16847455
224308_PM_s_at
224308_s_at
3765630
3765631
3765632
3765643
3765644
3765645
3765646
3765647
3765649
3765651
3765653
3765654
3765656
3765657
3765658
3765659
3765661
3765663
3765664
3765665
3765666
3765667
3765668
3765669
3765671
3765673
3765674
3765675
3765676
3765677
3765678
3765679
3765680
3765681
3765682
3765683
3765684
53264_at
57508
8017283
A_23_P420269
GE85381
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0006355
GO:0016020
GO:0016073
GO:0016180
GO:0031965
GO:0032039
GO:0034243
GO:0034472
GO:0043226
HMNXSV003021200
ILMN_1686553
PH_hs_0023419
TC17001770.hg
TC17002737.hg
g12053112_3p_a_at
Participates
as a component of
Integrator [nucleoplasm] (Homo sapiens)
Inferred To
INTS2 [nucleoplasm]
(Bos taurus)
INTS2 [nucleoplasm]
(Canis familiaris)
INTS2 [nucleoplasm]
(Gallus gallus)
INTS2 [nucleoplasm]
(Sus scrofa)
ints2 [nucleoplasm]
(Dictyostelium discoideum)
ints2 [nucleoplasm]
(Xenopus tropicalis)
Ints2 [nucleoplasm]
(Mus musculus)
Ints2 [nucleoplasm]
(Rattus norvegicus)
IntS2 [nucleoplasm]
(Drosophila melanogaster)
ints-2 [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of INTS2 [nucleoplasm]
(Danio rerio)
Cross References
ENSEMBL
ENST00000444766
,
ENSP00000414237
OpenTargets
ENSG00000108506
HPA
ENSG00000108506-INTS2
PRO
Q9H0H0
Pharos - Targets
Q9H0H0
PDB
8RBX
,
7PKS
,
8RBZ
,
7CUN
,
7YCX
,
8RC4
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.556
3
UniProt:P35414 APLNR
1
APLNR [plasma membrane]
(R-HSA-374259)
0.527
2
UniProt:P67775 PPP2CA
4
PPP2CA [cytosol]
(R-HSA-165971)
PPP2CA [nucleoplasm]
(R-HSA-165978)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
0.527
2
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