Reactome | IRF3(2-271) [cytosol]

IRF3(2-271) [cytosol]

Stable Identifier

R-HSA-9729696

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        SARS-CoV-2 nsp3 cleaves IRF3 (Homo sapiens)
        
        IRF3(2-271) [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14653 IRF3

Gene Names

IRF3

Chain

chain:1-427

Reference Genes

BioGPS Gene:3661 IRF3

COSMIC (genes):IRF3 IRF3

CTD Gene:3661 IRF3

dbSNP Gene:3661 IRF3

ENSEMBL:ENSG00000126456 IRF3

HGNC:6118 IRF3

KEGG:hsa:3661 IRF3

Monarch:3661 IRF3

NCBI Gene:3661 IRF3

OMIM:603734 IRF3

UCSC:Q14653 IRF3

Reference Transcript

Other Identifiers

11718672_x_at

11745498_a_at

11745499_x_at

11753805_a_at

11753806_x_at

11756572_x_at

16874347

202621_PM_at

202621_at

3661

371_at

3867981

3867982

3867983

3867984

3867985

3867986

3867987

3867988

3867989

3867990

3867991

3867992

3867993

3867994

3867995

3867996

3867997

3867998

3867999

3868000

3868001

3868002

3868003

3868005

3868006

3868007

3868008

3868009

3868010

3868011

3868012

8038416

A_23_P27677

A_33_P3327333

GE60425

GO:0000122

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001216

GO:0001227

GO:0001228

GO:0001819

GO:0002376

GO:0002753

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006915

GO:0006974

GO:0009299

GO:0009617

GO:0010468

GO:0012501

GO:0016071

GO:0019904

GO:0023019

GO:0031663

GO:0032481

GO:0032496

GO:0032727

GO:0032728

GO:0034142

GO:0035666

GO:0039530

GO:0042802

GO:0042803

GO:0042981

GO:0043123

GO:0043226

GO:0043330

GO:0043565

GO:0045087

GO:0045893

GO:0045944

GO:0050727

GO:0051607

GO:0060337

GO:0060340

GO:0071222

GO:0071360

GO:0071888

GO:0097300

GO:0098542

GO:0098586

GO:0140110

GO:0140374

GO:0140896

GO:1900017

GO:1990837

GO:1990841

HMNXSV003034896

ILMN_1765649

PH_hs_0004298

TC19001722.hg

Z56281_at

g4504724_3p_at

g4504724_3p_x_at

Participates

as an output of

SARS-CoV-2 nsp3 cleaves IRF3 (Homo sapiens)

Other forms of this molecule

IRF3 [cytosol]

IRF3(272-427) [cytosol]

p-4S,T404-IRF3 [cytosol]

p-4S,T404-IRF3 [nucleoplasm]

p-5S,T404-IRF3 [nucleoplasm]

Cross References

RefSeq

XP_016882255.1, NP_001184054.1, NP_001184053.1, XP_016882256.1, NP_001184052.1, NP_001562.1, NP_001184051.1, NP_001184057.1, XP_006723261.1, XP_006723260.1, NP_001184055.1, NP_001184056.1

OpenTargets

ENSG00000126456

ENSEMBL

ENST00000599223, ENST00000442265, ENST00000601291, ENST00000596765, ENST00000309877, ENSP00000310127, ENSP00000366344, ENSP00000400378, ENST00000600022, ENSP00000469113, ENSP00000470512, ENSP00000471896, ENSP00000472700, ENSP00000471358, ENST00000597198, ENST00000377139

HPA

ENSG00000126456-IRF3

PRO

Q14653

Pharos - Targets

Q14653

PDB

1ZOQ, 2O6G, 1J2F, 6SJA, 5JEM, 5JEL, 2O61, 6SIV, 7JFL, 5JEJ, 5JEK, 3A77, 5JER, 2PI0, 1T2K, 1QWT, 5JEO, 3QU6

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14653 IRF3	6	IRF3 [cytosol] (R-HSA-166251) IRF3(2-271) [cytosol] (R-HSA-9729696) IRF3(272-427) [cytosol] (R-HSA-9729737) p-4S,T404-IRF3 [cytosol] (R-HSA-166258) p-4S,T404-IRF3 [nucleoplasm] (R-HSA-177654) p-5S,T404-IRF3 [nucleoplasm] (R-HSA-936418)	0.97	18
UniProt:Q92793 CREBBP	4	CREBBP [nucleoplasm] (R-HSA-193545) CREBBP [cytosol] (R-HSA-9756493) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877)	0.929	12
UniProt:Q9UHD2 TBK1	5	p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) p-TBK1 [cytosol] (R-HSA-9008705) pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397)	0.92	10
UniProt:P0C6X7-PRO_0000037311 REP			0.656	5
UniProt:O14730 RIOK3	1	RIOK3 [cytosol] (R-HSA-6791522)	0.612	6
UniProt:Q9Y5Q3 MAFB	1	MAFB [nucleoplasm] (R-HSA-3788667)	0.556	4
UniProt:Q14164 IKBKE	5	IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) K63polyUb-K30,K401-IKBKE [cytosol] (R-HSA-9730436) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535)	0.544	2
UniProt:O43765 SGTA	1	SGTA [cytosol] (R-HSA-5423595)	0.543	3
UniProt:P10914 IRF1	2	IRF1 [nucleoplasm] (R-HSA-983456) IRF1 [cytosol] (R-HSA-1015686)	0.537	5
UniProt:Q96EN8 MOCOS	1	PXLP-K264-MOCOS [cytosol] (R-HSA-947549)	0.527	2
UniProt:Q96MH7 CE034			0.527	2
UniProt:Q6AI12 ANR40			0.527	2
UniProt:Q92990 GLMN	1	GLMN [cytosol] (R-HSA-8951779)	0.527	2
UniProt:O60684 KPNA6	2	KPNA6 [nucleoplasm] (R-HSA-9734665) KPNA6 [cytosol] (R-HSA-9734672)	0.524	3
UniProt:Q9Y3R0 GRIP1	2	GRIP1 [cytosol] (R-HSA-416633) GRIP1 [plasma membrane] (R-HSA-416638)	0.508	2
UniProt:P28749 RBL1	2	RBL1 [nucleoplasm] (R-HSA-389104) p-T369,S640,S964,S975-RBL1 [nucleoplasm] (R-HSA-1226085)	0.499	2
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.499	4
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.499	2

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