Reactome | p-S368-PPP2R5B [cytosol]

p-S368-PPP2R5B [cytosol]

Stable Identifier

R-HSA-6811453

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - Negative regulation of the PI3K/AKT network (Homo sapiens)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
        
        MAPKs phosphorylate PP2A (Homo sapiens)
        
        p-S368-PPP2R5B,p-S337-PPP2R5C [cytosol] (Homo sapiens)
        
        p-S368-PPP2R5B [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15173 PPP2R5B

Gene Names

PPP2R5B

Chain

chain:1-497

Reference Genes

BioGPS Gene:5526 PPP2R5B

COSMIC (genes):PPP2R5B PPP2R5B

CTD Gene:5526 PPP2R5B

dbSNP Gene:5526 PPP2R5B

ENSEMBL:ENSG00000068971 PPP2R5B

ENSEMBL_homo_sapiens_GENE:ENSG00000068971.14 PPP2R5B

HGNC:9310 PPP2R5B

KEGG Gene (Homo sapiens):5526 PPP2R5B

Monarch:5526 PPP2R5B

NCBI Gene:5526 PPP2R5B

OMIM:601644 PPP2R5B

UCSC:Q15173 PPP2R5B

Reference Transcript

RefSeq:NM_006244.3 PPP2R5B

Other Identifiers

11719874_a_at

16726572

204611_PM_s_at

204611_s_at

3334751

3334752

3334755

3334756

3334757

3334758

3334760

3334763

3334764

3334766

3334767

3334768

3334769

3334770

3334771

3334772

3334773

3334775

3334776

3334777

3334778

5526

635_PM_s_at

635_s_at

7941087

A_14_P120664

A_14_P138303

A_14_P200300

A_21_P0007145

A_23_P35796

A_33_P3318237

GE57773

GO:0000159

GO:0001932

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0007165

GO:0010976

GO:0019888

GO:0023052

GO:0030154

GO:0031334

GO:0031952

GO:0036211

GO:0043226

GO:0045944

GO:0048856

GO:0050730

GO:0051388

GO:0051726

GO:0065003

GO:0070317

GO:0071363

GO:0072542

GO:0098772

HMNXSV003021168

HMNXSV003034228

HMNXSV003044606

ILMN_2124082

L42374_s_at

PH_hs_0004286

TC11000611.hg

g5453951_3p_s_at

Participates

as a member of

p-S368-PPP2R5B,p-S337-PPP2R5C [cytosol] (Homo sapiens)

Other forms of this molecule

PPP2R5B [cytosol]

Inferred To

phospho-PPP2R5B [cytosol] (Bos taurus)

phospho-PPP2R5B [cytosol] (Canis familiaris)

phospho-PPP2R5B [cytosol] (Sus scrofa)

phospho-Ppp2r5b [cytosol] (Mus musculus)

phospho-Ppp2r5b [cytosol] (Rattus norvegicus)

Modified Residues

Name

O-phospho-L-serine at 368

Coordinate

368

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_006235.1

OpenTargets

ENSG00000068971

GeneCards

Q15173

HPA

ENSG00000068971-PPP2R5B

Ensembl

ENSP00000164133, ENSG00000068971, ENST00000164133

PRO

Q15173

Pharos - Targets

Q15173

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P67775 PPP2CA	4	MeL-PPP2CA [nucleoplasm] (R-HSA-8857791) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) PPP2CA [nucleoplasm] (R-HSA-165978) PPP2CA [cytosol] (R-HSA-165971)	0.908	8
UniProt:P30153 PPP2R1A	2	PPP2R1A [nucleoplasm] (R-HSA-165968) PPP2R1A [cytosol] (R-HSA-165982)	0.742	6
UniProt:Q92974 ARHGEF2	1	ARHGEF2 [cytosol] (R-HSA-195101)	0.527	2
UniProt:P46695 IER3	1	IER3 [cytosol] (R-HSA-6811515)	0.524	4
UniProt:O96017 CHEK2	3	p-T68-CHEK2 [nucleoplasm] (R-HSA-113825) CHEK2 [nucleoplasm] (R-HSA-113824) p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784)	0.508	2